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Controlled releasing properties of gelatin nanofabric device containing chlorhexidine

Park DU, Um HS, Chang BS, Lee SY, Yoo KY, Choi WY, Lee JK

We aimed to evaluate the degradation and antimicrobial activity of novel chlorhexidine-containing gelatin nanofabric devices and their cytotoxicity in animals. The electro-spun device with a size of 3×4×0.4 mm 3...
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Polydeoxyribonucleotide Attenuates Airway Inflammation Through A2AR Signaling Pathway in PM10-Exposed Mice

Hwang L, Jin JJ, Ko IG, Kim S, Cho YA, Sung JS, Choi CW, Chang BS

Purpose: Inhalation of air containing high amounts of particular matter (PM) causes various respiratory disorders including asthma, chronic obstructive pulmonary disease, and lung cancer. The changes of expression of inflammatory...
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Treatment Strategy for Impending Instability in Spinal Metastases

Kim YH, Kim J, Chang SY, Kim H, Chang BS

Background: Determining surgical management of a spinal metastasis is difficult owing to the involvement of multiple factors.The spinal instability neoplastic score (SINS) system is a reliable tool to evaluate instability...
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Treatment Strategy for Metastatic Spinal Tumors: A Narrative Review

Chang SY, Mok S, Park SC, Kim H, Chang BS

Metastatic spinal tumors are common, and their rising incidence can be attributed to the expanding aging population and increased survival rates among cancer patients. The decision-making process in the treatment...
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Volumetric Assessment of Fusion Mass and Its Clinical Correlations in Posterior Lumbar Interbody Fusion Depending on the Type of Bone Graft

Lee JW, Li QY, Kang KT, Chang BS, Lee CK, Yeom JS, Kim HJ

Study Design: A prospective observational cohort study. Objectives: This study was conducted to analyze associations between the volume of the fusion mass and clinical outcomes 1 year after posterior lumbar interbody...
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Combination Therapy With Polydeoxyribonucleotide and Pirfenidone Alleviates Symptoms of Acute Respiratory Distress Syndrome in Human Lung Epithelial A549 Cells

Hwang JJ, Ko IG, Jin JJ, Hwang L, Kim SH, Jeon JW, Paik SS, Chang BS, Choi CW

Purpose: Acute respiratory distress syndrome (ARDS) is characterized by its acute onset of symptoms such as bilateral pulmonary infiltrates, severe hypoxemia, and pulmonary edema. Many patients with ARDS survive in...
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Medical Care Utilization Behavior for the Diagnosis and Treatment of Spine Disease: A Questionnairebased Study of Orthopaedic Spine Center Outpatients at a Tertiary Educational Hospital

Park SM, Go SJ, Han H, Kim HJ, Kim H, Chang BS, Yeom JS

Study Design: Prospective survey analysis. Objectives: The purpose of our study was to investigate medical care utilization behavior and the conceptions of disease treatment among spine disease patients. Summary of Literature Review:...
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Clinical Significance of Improved Intraoperative Neurophysiological Monitoring Signal during Spine Surgery: A Retrospective Study of a Single-Institution Prospective Cohort

Wi SM, Lee HJ, Kang T, Chang SY, Kim SM, Chang BS, Lee CK, Kim H

Study Design: Retrospective case series. Purpose: We reviewed the cases that showed significant improvement of intraoperative neurophysiological monitoring (IONM) signals during spine surgery to assess whether there is a correlation with...
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Antimicrobial effect of toothbrush with light emitting diode on dental biofilm attached to zirconia surface: an in vitro study

Park JH, Kim YG, Um HS, Lee SY, Lee JK, Chang BS

PURPOSE: The purpose of this study was to evaluate the antimicrobial effects of a toothbrush with light-emitting diodes (LEDs) on periodontitis-associated dental biofilm attached to a zirconia surface by static...
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Restoration of the Spinous Process Following Muscle-Preserving Posterior Lumbar Decompression via Sagittal Splitting of the Spinous Process

Wi SM, Lee HJ, Chang SY, Kwon OH, Lee CK, Chang BS, Kim H

BACKGROUND: In lumbar spinal stenosis, spinous process-splitting decompression has demonstrated good clinical outcomes with preservation of the posterior ligamentous complex and paraspinal muscles in comparison to conventional laminectomy, but the...
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Clinical Significance of Resection Type and Margin following Surgical Treatment for Primary Sarcoma of the Spine: A Multi-Center Retrospective Study

Chang SY, Kim H, Park SJ, Chang BS, Lee CS, Lee CK

STUDY DESIGN: A retrospective multi-center study. OBJECTIVES: To analyze oncological outcomes according to the resection type and surgical margin following surgical treatment for primary spinal sarcoma. SUMMARY OF LITERATURE REVIEW: Previous studies...
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The Spinal Instability Neoplastic Score (SINS) as a Surgical Decision-Making Tool for the Treatment of Spine Metastasis

Park SM, Kim H, Ha JH, Lee SJ, Kim HJ, Yeom JS, Lee CK, Chang BS

STUDY DESIGN: Retrospective cohort study. OBJECTIVES: To investigate the potential clinical use of the spinal instability neoplastic score (SINS) for determining the surgical strategy, especially regarding the need for anterior support. SUMMARY...
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Efficacy of an LED toothbrush on a Porphyromonas gingivalis biofilm on a sandblasted and acid-etched titanium surface: an in vitro study

Lee H, Kim YG, Um HS, Chang BS, Lee SY, Lee JK

PURPOSE: The aim of this study was to evaluate the antimicrobial effect of a newly devised toothbrush with light-emitting diodes (LEDs) on Porphyromonas gingivalis attached to sandblasted and acid-etched titanium...
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Radiographic and Clinical Outcomes of Robot-Assisted Posterior Pedicle Screw Fixation: Two-Year Results from a Randomized Controlled Trial

Park SM, Kim HJ, Lee SY, Chang BS, Lee CK, Yeom JS

PURPOSE: We prospectively assessed the early radiographic and clinical outcomes (minimum follow-up of 2 years) of robot-assisted pedicle screw fixation (Robot-PSF) and conventional freehand pedicle screw fixation (Conv-PSF). MATERIALS AND METHODS:...
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Prevalence of Frailty in Patients with Osteoporotic Vertebral Compression Fracture and Its Association with Numbers of Fractures

Kim HJ, Park S, Park SH, Park J, Chang BS, Lee CK, Yeom JS

PURPOSE: To assess the association between frailty and osteoporotic vertebral compression fracture (OVCF) and to evaluate the relationship between numbers of OVCFs and frailty. MATERIALS AND METHODS: We enrolled 760 subjects,...
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Determination of the optimal diabetes duration for bone regeneration experiments in an alloxan-induced diabetic rabbit calvarial defect model

Jeong SH, Jung BH, Yoo KY, Um HS, Chang BS, Lee JK, Choi WY

PURPOSE: The purpose of this study was to evaluate the optimal diabetes duration for bone regeneration experiments in an alloxan monohydrate (ALX)–induced diabetic rabbit calvarial defect model by evaluating the...
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Prognosis of Single Spinal Metastatic Tumors: Predictive Value of the Spinal Instability Neoplastic Score System for Spinal Adverse Events

Chang SY, Ha JH, Seo SG, Chang BS, Lee CK, Kim H

STUDY DESIGN: This was a retrospective cohort study. PURPOSE: We evaluated the predictive value of the Spinal Instability Neoplastic Score (SINS) system for spinal adverse events (SAEs) in patients with single...
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Comparison of periodontitis-associated oral biofilm formation under dynamic and static conditions

Song WS, Lee JK, Park SH, Um HS, Lee SY, Chang BS

PURPOSE: The purpose of this study was to compare the characteristics of single- and dual-species in vitro oral biofilms made by static and dynamic methods. METHODS: Hydroxyapatite (HA) disks, 12.7 mm...
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Prevalence of Neuropathic Pain and Patient-Reported Outcomes in Korean Adults with Chronic Low Back Pain Resulting from Neuropathic Low Back Pain

Kim JH, Hong JT, Lee CS, Kim KS, Suk KS, Kim JH, Park YS, Chang BS, Jun DS, Kim YH, Lee JH, Min WK, Lee JS, Park SY, Oh IS, Hong JY, Shin HC, Kim WK, Kim JH, Lee JK, Kim IS, Ha Y, Im SB, Kim SW, Han IH, Shin JJ, Rim BC, Seo BJ, Kim YJ, Lee J

STUDY DESIGN: A noninterventional, multicenter, cross-sectional study. PURPOSE: We investigated the prevalence of neuropathic pain (NP) and patient-reported outcomes (PROs) of the quality of life (QoL) and functional disability in Korean...
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Determination of the critical diabetes duration in a streptozotocin-induced diabetic rat calvarial defect model for experimentation regarding bone regeneration

Kim HJ, Jung BH, Yoo KY, Han JW, Um HS, Chang BS, Lee JK

PURPOSE: The purpose of this study was to determine the critical diabetes duration in a streptozotocin (STZ)-induced diabetic rat calvarial defect model for experimentation regarding bone regeneration by evaluating the...
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