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Anterior Cervical Discectomy and Fusion Using Escherichia coli-Derived Recombinant Human Bone Morphogenetic Protein-2: A Pilot Study

Son HJ, Chang BS, Chang SY, Park HS, Kim H

Background: Recombinant human bone morphogenetic protein-2 (BMP-2) is an osteoinductive growth factor widely used in orthopedic surgery; it is also known to be associated with postoperative airway compromise or dysphagia...
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Radiographic Factors for Progression of Thoracolumbar Kyphosis in Achondroplasia Patients after Walking Age: A Generalized Estimating Equation Analysis

Mok S, Chang SY, Park SC, Chae I, Kim H, Chang BS, Cho TJ, Ko JM

Background: This study aimed to analyse the trends in changes of radiologic parameters according to age to predict factors affecting the progression of thoracolumbar kyphosis (TLK). Methods: Records of patients with...
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Anterior Thigh Pain Following Minimally Invasive Oblique Lateral Interbody Fusion: Multivariate Analysis from a Prospective Case Series

Chang SY, Lee WS, Mok S, Park SC, Kim H, Chang BS

Background: Oblique lateral interbody fusion (OLIF) involves the antepsoas approach and psoas major muscle (PMM) retraction to insert the interbody cage orthogonally. Therefore, OLIF is often associated with postoperative anterior...
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Controlled releasing properties of gelatin nanofabric device containing chlorhexidine

Park DU, Um HS, Chang BS, Lee SY, Yoo KY, Choi WY, Lee JK

We aimed to evaluate the degradation and antimicrobial activity of novel chlorhexidine-containing gelatin nanofabric devices and their cytotoxicity in animals. The electro-spun device with a size of 3×4×0.4 mm 3...
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Polydeoxyribonucleotide Attenuates Airway Inflammation Through A2AR Signaling Pathway in PM10-Exposed Mice

Hwang L, Jin JJ, Ko IG, Kim S, Cho YA, Sung JS, Choi CW, Chang BS

Purpose: Inhalation of air containing high amounts of particular matter (PM) causes various respiratory disorders including asthma, chronic obstructive pulmonary disease, and lung cancer. The changes of expression of inflammatory...
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Treatment Strategy for Impending Instability in Spinal Metastases

Kim YH, Kim J, Chang SY, Kim H, Chang BS

Background: Determining surgical management of a spinal metastasis is difficult owing to the involvement of multiple factors.The spinal instability neoplastic score (SINS) system is a reliable tool to evaluate instability...
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Treatment Strategy for Metastatic Spinal Tumors: A Narrative Review

Chang SY, Mok S, Park SC, Kim H, Chang BS

Metastatic spinal tumors are common, and their rising incidence can be attributed to the expanding aging population and increased survival rates among cancer patients. The decision-making process in the treatment...
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Volumetric Assessment of Fusion Mass and Its Clinical Correlations in Posterior Lumbar Interbody Fusion Depending on the Type of Bone Graft

Lee JW, Li QY, Kang KT, Chang BS, Lee CK, Yeom JS, Kim HJ

Study Design: A prospective observational cohort study. Objectives: This study was conducted to analyze associations between the volume of the fusion mass and clinical outcomes 1 year after posterior lumbar interbody...
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Combination Therapy With Polydeoxyribonucleotide and Pirfenidone Alleviates Symptoms of Acute Respiratory Distress Syndrome in Human Lung Epithelial A549 Cells

Hwang JJ, Ko IG, Jin JJ, Hwang L, Kim SH, Jeon JW, Paik SS, Chang BS, Choi CW

Purpose: Acute respiratory distress syndrome (ARDS) is characterized by its acute onset of symptoms such as bilateral pulmonary infiltrates, severe hypoxemia, and pulmonary edema. Many patients with ARDS survive in...
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Medical Care Utilization Behavior for the Diagnosis and Treatment of Spine Disease: A Questionnairebased Study of Orthopaedic Spine Center Outpatients at a Tertiary Educational Hospital

Park SM, Go SJ, Han H, Kim HJ, Kim H, Chang BS, Yeom JS

Study Design: Prospective survey analysis. Objectives: The purpose of our study was to investigate medical care utilization behavior and the conceptions of disease treatment among spine disease patients. Summary of Literature Review:...
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Clinical Significance of Improved Intraoperative Neurophysiological Monitoring Signal during Spine Surgery: A Retrospective Study of a Single-Institution Prospective Cohort

Wi SM, Lee HJ, Kang T, Chang SY, Kim SM, Chang BS, Lee CK, Kim H

Study Design: Retrospective case series. Purpose: We reviewed the cases that showed significant improvement of intraoperative neurophysiological monitoring (IONM) signals during spine surgery to assess whether there is a correlation with...
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Clinical Significance of Resection Type and Margin following Surgical Treatment for Primary Sarcoma of the Spine: A Multi-Center Retrospective Study

Chang SY, Kim H, Park SJ, Chang BS, Lee CS, Lee CK

STUDY DESIGN: A retrospective multi-center study. OBJECTIVES: To analyze oncological outcomes according to the resection type and surgical margin following surgical treatment for primary spinal sarcoma. SUMMARY OF LITERATURE REVIEW: Previous studies...
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Antimicrobial effect of toothbrush with light emitting diode on dental biofilm attached to zirconia surface: an in vitro study

Park JH, Kim YG, Um HS, Lee SY, Lee JK, Chang BS

PURPOSE: The purpose of this study was to evaluate the antimicrobial effects of a toothbrush with light-emitting diodes (LEDs) on periodontitis-associated dental biofilm attached to a zirconia surface by static...
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Restoration of the Spinous Process Following Muscle-Preserving Posterior Lumbar Decompression via Sagittal Splitting of the Spinous Process

Wi SM, Lee HJ, Chang SY, Kwon OH, Lee CK, Chang BS, Kim H

BACKGROUND: In lumbar spinal stenosis, spinous process-splitting decompression has demonstrated good clinical outcomes with preservation of the posterior ligamentous complex and paraspinal muscles in comparison to conventional laminectomy, but the...
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Determination of the optimal diabetes duration for bone regeneration experiments in an alloxan-induced diabetic rabbit calvarial defect model

Jeong SH, Jung BH, Yoo KY, Um HS, Chang BS, Lee JK, Choi WY

PURPOSE: The purpose of this study was to evaluate the optimal diabetes duration for bone regeneration experiments in an alloxan monohydrate (ALX)–induced diabetic rabbit calvarial defect model by evaluating the...
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Prognosis of Single Spinal Metastatic Tumors: Predictive Value of the Spinal Instability Neoplastic Score System for Spinal Adverse Events

Chang SY, Ha JH, Seo SG, Chang BS, Lee CK, Kim H

STUDY DESIGN: This was a retrospective cohort study. PURPOSE: We evaluated the predictive value of the Spinal Instability Neoplastic Score (SINS) system for spinal adverse events (SAEs) in patients with single...
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The Spinal Instability Neoplastic Score (SINS) as a Surgical Decision-Making Tool for the Treatment of Spine Metastasis

Park SM, Kim H, Ha JH, Lee SJ, Kim HJ, Yeom JS, Lee CK, Chang BS

STUDY DESIGN: Retrospective cohort study. OBJECTIVES: To investigate the potential clinical use of the spinal instability neoplastic score (SINS) for determining the surgical strategy, especially regarding the need for anterior support. SUMMARY...
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Efficacy of an LED toothbrush on a Porphyromonas gingivalis biofilm on a sandblasted and acid-etched titanium surface: an in vitro study

Lee H, Kim YG, Um HS, Chang BS, Lee SY, Lee JK

PURPOSE: The aim of this study was to evaluate the antimicrobial effect of a newly devised toothbrush with light-emitting diodes (LEDs) on Porphyromonas gingivalis attached to sandblasted and acid-etched titanium...
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Radiographic and Clinical Outcomes of Robot-Assisted Posterior Pedicle Screw Fixation: Two-Year Results from a Randomized Controlled Trial

Park SM, Kim HJ, Lee SY, Chang BS, Lee CK, Yeom JS

PURPOSE: We prospectively assessed the early radiographic and clinical outcomes (minimum follow-up of 2 years) of robot-assisted pedicle screw fixation (Robot-PSF) and conventional freehand pedicle screw fixation (Conv-PSF). MATERIALS AND METHODS:...
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Prevalence of Frailty in Patients with Osteoporotic Vertebral Compression Fracture and Its Association with Numbers of Fractures

Kim HJ, Park S, Park SH, Park J, Chang BS, Lee CK, Yeom JS

PURPOSE: To assess the association between frailty and osteoporotic vertebral compression fracture (OVCF) and to evaluate the relationship between numbers of OVCFs and frailty. MATERIALS AND METHODS: We enrolled 760 subjects,...
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