- The colchicine derivative CT20126 shows a novel microtubule-modulating activity with apoptosis
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Kim SK, Cho SM, Kim H, Seok H, Kim SO, Kwon TK, Chang JS
- KMID: 2154238
- Exp Mol Med.
- 2013 Apr;45(4):e19.
New colchicine analogs have been synthesized with the aim of developing stronger potential anticancer activities. Among the analogs, CT20126 has been previously reported to show immunosuppressive activities. Here, we report... -
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- Isolation of Endothelial Progenitor Cells from Cord Blood and Induction of Differentiation by Ex Vivo Expansion
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Shin JW, Lee DW, Kim MJ, Song KS, Kim HS, Kim HO
- KMID: 1734053
- Yonsei Med J.
- 2005 Apr;46(2):260-267.
- doi: 10.3349/ymj.2005.46.2.260
Endothelial progenitor cells (EPCs) have been reported to possess the capacity to colonize vascular grafts and hold promise for therapeutic neovascularization. However, limited quantities of EPCs have been the major... -
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- The Inhibitory Effect of Curcumin on the Growth of Human Colon Cancer Cells (HT-29, WiDr) in vitro
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Kim KH, Park HY, Nam JH, Park JE, Kim JY, Park MI, Chung KO, Park KY, Koo JY
- KMID: 772765
- Korean J Gastroenterol.
- 2005 Apr;45(4):277-284.
BACKGROUND/AIMS: The effects of curcumin on the growth of human colon cancer cell lines, HT-29 and WiDr cells were examined and the effects of 5-fluorouracil (5-FU) were also studied.... -
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- Differential inhibition of endothelial cell proliferation and migration by urokinase subdomains: amino-terminal fragment and kringle domain
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Kim KS, Hong YK, Lee Y, Shin JY, Chang SI, Chung SI, Joe YA
- KMID: 1119342
- Exp Mol Med.
- 2003 Dec;35(6):578-585.
The serine protease urokinase-type plasminogen activator (uPA) is implicated in pericellular proteolysis in a variety of physiological and pathological processes including angiogenesis and tumor metastasis. The kringle domain of uPA... -
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- Dexamethasone-induced differentiation of pancreatic AR42J cell involves p21(waf1/cip1)and MAP kinase pathway
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Eum WS, Li MZ, Sin GS, Choi SY, Park JB, Lee JY, Kwon HY
- KMID: 1093610
- Exp Mol Med.
- 2003 Oct;35(5):379-384.
Dexamethasone converts pluripotent pancreatic AR42J cells into exocrine cells expressing digestive enzymes. In order to address molecular mechanism of this differentiation, we have investigated the role of mitogen-activated protein (MAP)... -
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- The Effects of Recombinant Human BMP-7, Prepared from a COS-7 Expression System, on the Proliferation and Differentiation of Rat Newborn Calvarial Osteoblasts
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Lee DH, Suh H, Han DW, Park BJ, Lee JW, Park JC
- KMID: 720897
- Yonsei Med J.
- 2003 Aug;44(4):593-601.
- doi: 10.3349/ymj.2003.44.4.593
A family of proteins, the bone morphogenetic proteins (BMPs), which promote osteoblast differentiation and bone mineralization, have recently been identified. One, BMP-7, has shown the ability to induce cartilage and... -
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- Effect of Nitric Oxide on the Proliferation of Cultured Porcine Trabecular Meshwork Cells
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Kim JW, Heo H, Lee HW
- KMID: 754335
- Korean J Ophthalmol.
- 2003 Jun;17(1):1-6.
- doi: 10.3341/kjo.2003.17.1.1
To investigate the effect of nitric oxide (NO) on the proliferation of trabecular meshwork (TM) cells, primarily cultured porcine TM cells were exposed to NO donor (SNAP, -nitroso-N-acetyl-D, L-penicillamine) with... -
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- The Effects of Tamoxifen on Human Hepatocelluar Carcinoma Cell Proliferation and Transforming Growth Factor-beta1 Expression
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Shin JW, Chung YH, Park MI, Kim JA, Choi MH, Lee YJ, Ryu SH, Park NH, Lee HC, Lee YS, Suh DJ, Yu ES
- KMID: 1011390
- Korean J Hepatol.
- 2003 Mar;9(1):10-16.
BACKGROUND/AIMS: Tamoxifen has been tried in patients with hepatocellular carcinoma (HCC), however, its inhibitory mechanism remains unknown. In this study, we evaluated the effects of tamoxifen on HCC cell... -
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- Anti-HER2/neu Peptide Producing Vector System for Biologic Therapy - Is It Possible to Mass-produce the Peptide?
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Park BW, Kim KS, Heo MK, Lee KS, Kim EK, Kim KS
- KMID: 1719070
- Yonsei Med J.
- 2003 Feb;44(1):58-64.
- doi: 10.3349/ymj.2003.44.1.58
A humanized monoclonal antibody against HER2 has been using in a clinical setting and has been shown to possess therapeutic properties. A mimetic peptide against HER2 was also reported to... -
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- Neural cell adhesion molecule (NCAM) promotes the differentiation of hippocampal precursor cells to a neuronal lineage, especially to a glutamatergic neural cell type
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Shin MH, Lee EG, Lee SH, Lee YS, Son H
- KMID: 1121093
- Exp Mol Med.
- 2002 Dec;34(6):401-410.
Rat hippocampal precursor cells isolated from hippocampi of embryonic day 16.5 (E16.5) rat embryos were found to proliferate in the presence of basic fibroblast growth factor. Addition of soluble... -
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- Requirement of Metabolic Activation for Estrogenic Activity of Pueraria mirifica
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Lee YS, Park JS, Cho SD, Son JK, Cherdshewasart W, Kang KS
- KMID: 1097343
- J Vet Sci.
- 2002 Dec;3(4):273-277.
A wide range of chemicals derived from plant and human-made xenobiotics are reported to have hormonal activities. The present study was performed to examine the estrogenic effect of Kwao Keur,... -
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- Expression and Regulation of Endothelial Nitric Oxide Synthase by Vascular Endothelial Growth Factor in ECV 304 Cells
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Park JS, Hong GR, Baek SW, Shin DG, Kim YJ, Shim BS
- KMID: 648670
- J Korean Med Sci.
- 2002 Apr;17(2):161-167.
- doi: 10.3346/jkms.2002.17.2.161
Nitric oxide (NO) seems to play a pivotal role in the vascular endothelial growth factor (VEGF)-induced endothelial cell proliferation. This study was designed to investigate the role and intracellular signal... -
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- American Ginseng Transcriptionally Activates p21 mRNA in Breast Cancer Cell Lines
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Duda RB, Kang SS, Archer SY, Meng S, Hodin RA
- KMID: 1721175
- J Korean Med Sci.
- 2001 Dec;16(Suppl):S54-S60.
- doi: 10.3346/jkms.2001.16.S.S54
American ginseng (AG) has been demonstrated to inhibit breast cancer cell growth in vitro. p21 protein, a universal cell cycle inhibitor, binds cyclin-CDK complexes, an important mechanism in cell cycle... -
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- Inhibition of rac1 Reduces PDGF-induced Reactive Oxygen Species and Proliferation in Vascular Smooth Muscle Cells
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Kong G, Lee S, Kim KS
- KMID: 648350
- J Korean Med Sci.
- 2001 Dec;16(6):712-718.
- doi: 10.3346/jkms.2001.16.6.712
In vascular smooth muscle cells, reactive oxygen species (ROS) were known to mediate platelet-derived growth factor (PDGF)-induced cell proliferation and NADH/NADPH oxidase is the major source of ROS. NADH/NADPH oxidase... -
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- Detection of Telomerase Activity in Psoriasis Lesional Skin and Correlaton with Ki-67 Expression and Suppression by Retinoic Acid
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Jang HS, Oh CK, Jo JH, Kim YS, Kwon KS
- KMID: 2157573
- J Korean Med Sci.
- 2001 Oct;16(5):623-629.
- doi: 10.3346/jkms.2001.16.5.623
Telomerase activity is usually detected in most tumor tissues but not in normal tissues. Recently, there is increasing evidence that telomerase activity is associated with cell proliferation without malignancy, whereas... -
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- Varying Effects of Intravenous Immunoglobulin on Mononuclear Cell Proliferation In Vitro
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Lee KY, Koh DK, Lee JS, Whang KT
- KMID: 2157559
- J Korean Med Sci.
- 2001 Oct;16(5):544-548.
- doi: 10.3346/jkms.2001.16.5.544
Intravenous immunoglobulin (IVIG) is being increasingly used to treat numerous immune-mediated diseases. However, there is a paucity of knowledge on the specific mode of action of IVIG in vivo. In... -
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- Interaction of TGF-beta1 and rhBMP-2 on Human Bone Marrow Stromal Cells Cultured in Collagen Gel Matrix
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Kim MK, Niyibizi C
- KMID: 720631
- Yonsei Med J.
- 2001 Jun;42(3):338-344.
- doi: 10.3349/ymj.2001.42.3.338
Transforming growth factor-beta1 (TGF-beta1) and bone morphogenetic protein-2 (BMP-2) are abundant proteins in the bone matrix. However, their interaction in controlling osteoblast differentiation is not clearly understood. In this study,... -
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- TGF-betas Synthesized by RPE Cells Have Autocrine Activity on Mesenchymal Transformation and Cell Proliferation
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Lee SC, Kim SH, Koh HJ, Kwon OW
- KMID: 720621
- Yonsei Med J.
- 2001 Jun;42(3):271-277.
- doi: 10.3349/ymj.2001.42.3.271
The present study investigated the effects of transforming growth factor (TGF)-beta on retinal pigment epithelial (RPE) transformation in a simplified model and also whether or not TGF-beta exhibits similar proliferation... -
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- Analysis of methods for the generation of dendritic cells from human peripheral blood monocytes
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Choi GS, Kang JM, Lee MG
- KMID: 1062244
- Yonsei Med J.
- 2000 Oct;41(5):642-650.
- doi: 10.3349/ymj.2000.41.5.642
Dendritic cells (DC) are highly efficient antigen-presenting cells that initiate the primary immune response. Several laboratories have developed culture systems for human DC from peripheral blood monocytes. Most of these... -
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- Effect of short-term ethanol on the proliferative response of Swiss 3T3 cells to mitogenic growth factors
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Yeo EJ, Lim HK, Park SC
- KMID: 755081
- Exp Mol Med.
- 2000 Sep;32(3):161-169.
Both adaptive and deleterious responses of cells to ethanol are likely triggered by short-term interactions of the cells with ethanol. Many studies have demonstrated the direct effect of ethanol... -
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