- Decreased expression of DNA repair proteins Ku70 and Mre11 is associated with aging and may contribute to the cellular senescence
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Ju YJ, Lee KH, Park JE, Yi YS, Yun MY, Ham YH, Kim TJ, Choi HM, Han GJ, Lee JH, Lee J, Han JS, Lee KM, Park GH
- KMID: 1115947
- Exp Mol Med.
- 2006 Dec;38(6):686-693.
The gradual loss of telomeric DNA can contribute to replicative senescence and thus, having longer telomeric DNA is generally considered to provide a longer lifespan. Maintenance and stabilization of telomeric... -
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- Mouse models for telomere and telomerase biology
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Cheong C, Hong KU, Lee HW
- KMID: 1094694
- Exp Mol Med.
- 2003 Jun;35(3):141-153.
Telomeres serve a critical role in maintenance of genomic stability in all eukaryotes, from yeast to human. The maintenance of telomeres is achieved by the telomerase complex, which is largely... -
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- The Role of Foxo3 in Leydig Cells
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Choi YS, Song JE, Kong BS, Hong JW, Novelli S, Lee EJ
- KMID: 2345887
- Yonsei Med J.
- 2015 Nov;56(6):1590-1596.
- doi: 10.3349/ymj.2015.56.6.1590
PURPOSE: Foxo3 in female reproduction has been reported to regulate proliferation of granulose cells that form follicles. There are no reports so far that discuss on the role of Foxo3... -
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