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Investigation of a pre-clinical mandibular bone notch defect model in miniature pigs: clinical computed tomography, micro-computed tomography, and histological evaluation

Carlisle P, Guda T, Silliman D, Lien W, Hale RG, Brown Baer PR

OBJECTIVES: To validate a critical-size mandibular bone defect model in miniature pigs. MATERIALS AND METHODS: Bilateral notch defects were produced in the mandible of dentally mature miniature pigs. The right mandibular...
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Are critical size bone notch defects possible in the rabbit mandible?

Carlisle P, Guda T, Silliman D, Hale RG, Brown Baer PR

OBJECTIVES: Small animal maxillofacial models, such as non-segmental critical size defects (CSDs) in the rabbit mandible, need to be standardized for use as preclinical models of bone regeneration to mimic...
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