- Effects of Calcium Channel Blockers and Insulin on the Platelet Function in Patients with Diabetes Mellitus
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Lee YS, Hahm KS, Lee SY
- KMID: 693024
- Yonsei Med J.
- 1986 Jun;27(2):132-137.
- doi: 10.3349/ymj.1986.27.2.132
Platelet aggregability was compared between platelets isolated from normal subjects and patients with diabetes mellitus in order to evaluate the effects of calcium channel blockers and insulin on the platelet... -
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- Inhibitory Effects of Potassium Channel Blockers on Carbachol-induced Contraction in Rat Detrusor Muscle
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Oh SJ, Ahn SC
- KMID: 1130042
- J Korean Med Sci.
- 2003 Oct;18(5):701-706.
- doi: 10.3346/jkms.2003.18.5.701
We present accidental findings that potassium channel blockers, such as tetraethyl-ammonium (TEA) or 4-aminopyridine (4-AP), inhibit the sustained tonic contraction induced by carbachol in rat detrusor muscle strips. The relatively... -
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- Co-activation of Gi and Gq proteins exerts synergistic effect on human platelet aggregation through activation of phospholipase C and Ca2+ signalling pathways
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Shah BH, Siddiqui A, Qureshi KA, Khan M, Rafi S, Ujan VA, Yakoob MY, Rasheed H, Saeed SA
- KMID: 755026
- Exp Mol Med.
- 1999 Mar;31(1):42-46.
Our previous studies have shown that subthreshold concentrations of two platelet agonists exert synergistic effects on platelet aggregation. Here we studied the mechanism of synergistic interaction of 5-hydroxytryptamine (5-HT) and epinephrine mediated platelet... -
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- Doxorubicin-induced reactive oxygen species generation and intracellular Ca2+increase are reciprocally modulated in rat cardiomyocytes
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Kim SY, Kim SJ, Kim BJ, Rah SY, Chung SM, Im MJ, Kim UH
- KMID: 1098088
- Exp Mol Med.
- 2006 Oct;38(5):535-545.
Doxorubicin (DOX) is one of the most potent anticancer drugs and induces acute cardiac arrhythmias and chronic cumulative cardiomyopathy. Though DOX-induced cardiotoxicity is known to be caused mainly by ROS... -
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- Influence of calcium ion on host cell invasion and intracellular replication by Toxoplasma gondii
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Song HO, Ahn MH, Ryu JS, Min DY, Joo KH, Lee YH
- KMID: 1720488
- Korean J Parasitol.
- 2004 Dec;42(4):185-193.
- doi: 10.3347/kjp.2004.42.4.185
Toxoplasma gondii is an obligate intracellular protozoan parasite, which invades a wide range of hosts including humans. The exact mechanisms involved in its invasion are not fully understood. This study... -
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- Serotonin contracts the rat mesenteric artery by inhibiting 4-aminopyridine-sensitive Kv channels via the 5-HT2A receptor and Src tyrosine kinase
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Sung DJ, Noh HJ, Kim JG, Park SW, Kim B, Cho H, Bae YM
- KMID: 2154286
- Exp Mol Med.
- 2013 Dec;45(12):e67.
Serotonin (5-hydroxytryptamine (5-HT)) is a neurotransmitter that regulates a variety of functions in the nervous, gastrointestinal and cardiovascular systems. Despite such importance, 5-HT signaling pathways are not entirely clear. We... -
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- Effect of Ca2+ channel blockers, external Ca2+ and phospholipase A2 inhibitors on t-butylhydroperoxide-induced lipid peroxidation and toxicity in rat liver slices
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Heo J, Kim GH, Lee KS, Go WU, Ju HJ, Park SK, Song CS, Song GA, Cho M, Yang US, Moon HK, Kim YK
- KMID: 1051573
- Korean J Intern Med.
- 1997 Jun;12(2):193-200.
OBJECTIVES: This study was undertaken to examine the effect of oxidant on lipid peroxidation and lethal cell injury in rat liver slices. METHODS: t-Butylhydroperoxide (t-BHP) was employed as a model... -
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- Characteristics of Potassium and Calcium Currents of Hepatic Stellate Cells (Ito) in Rat
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Lee KI, Kong ID, Baik SK, Kim HS, Lee DK, Kwon SO, Chun BG
- KMID: 721416
- Yonsei Med J.
- 2004 Aug;45(4):649-660.
- doi: 10.3349/ymj.2004.45.4.649
Hepatic stellate cells (HSCs) are known to play a role in the pathogenesis of the increased intrahepatic vascular resistance found in chronic liver diseases. The aim of this study was... -
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- Effects of hypoxia on pulmonary vascular contractility
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Lee YH, Seo JH, Kang BS
- KMID: 711556
- Yonsei Med J.
- 1998 Jun;39(3):261-267.
- doi: 10.3349/ymj.1998.39.3.261
Although hypoxic pulmonary vasoconstriction (HPV) has been recognized by many researchers, the precise mechanism remains unknown. As isolated pulmonary arteries will constrict in vitro in the response to hypoxia, the... -
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- Mechanism of UV light-induced photorelaxation in isolated rat aorta
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Kim JH, Hong Y, Shim CS
- KMID: 1094645
- J Vet Sci.
- 2000 Dec;1(2):81-86.
Isolated rat thoracic aorta which is pharmacologically precontracted by phenylephrine induces photorelaxation when exposed to long wave length UV-light. The aim of the present study was to characterize the mechanism... -
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- Assessment of Hemorheological Deformability of Human Red Cells Exposed to tert-Butyl Hydroperoxide, Verapamil and Ascorbate by Ektacytometer
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Kim DH, Kim YK, Won DI, Shin S, Suh JS
- KMID: 1781563
- Korean J Lab Med.
- 2008 Oct;28(5):325-331.
- doi: 10.3343/kjlm.2008.28.5.325
BACKGROUND: Normal erythrocyte is deformable and this facilitates blood flow in the capillaries. Oxidative stress reduces the deformability of erythrocytes, and influences on blood flow in microcirculation. The objective of... -
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- Effects of Risedronate on Osteoarthritis of the Knee
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Iwamoto J, Takeda T, Sato Y, Matsumoto
- KMID: 1126013
- Yonsei Med J.
- 2010 Mar;51(2):164-170.
- doi: 10.3349/ymj.2010.51.2.164
The purpose of the present study was to discuss the effects of risedronate on osteoarthritis (OA) of the knee by reviewing the existing literature. The literature was searched with PubMed,... -
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