- Regulation of the Expression of a Calcineurin Inhibitor, ZAKI-4alpha
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Cao X, Kambe F, Seo H
- KMID: 2200839
- J Korean Soc Endocrinol.
- 2006 Aug;21(4):261-265.
- doi: 10.3803/jkes.2006.21.4.261
No abstract available. -
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- Calcineurin Inhibitor-induced Hyperlipidemia and Diabetes Mellitus
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Yang CW
- KMID: 2253257
- Korean J Nephrol.
- 2008 May;27(3):277-279.
No abstract available. -
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- Linear Lichen Planopilaris of the Face Successfully Treated with Topical Calcineurin Inhibitor
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Seo HM, Lee H, Bang CH, Lee JH, Park YM, Lee JY
- KMID: 2457699
- Korean J Dermatol.
- 2019 Aug;57(7):412-413.
No abstract available. -
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- Implications of Calcineurin/NFAT Inhibitors' Regulation of Dendritic Cells and Innate Immune Cells in Islet Xenotransplantation
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Kim YH, Lee WW, Park CG
- KMID: 2168737
- J Bacteriol Virol.
- 2016 Mar;46(1):1-12.
- doi: 10.4167/jbv.2016.46.1.1
Calcineurin inhibitors, such as cyclosporine and tacrolimus (FK506) are broadly used in organ transplantations as immune suppressants. As the calcineurin/NFAT signaling pathway has been identified as critical pathway in the... -
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- FK506 reduces calpain-regulated calcineurin activity in both the cytoplasm and the nucleus
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Lee SH, Choi J, Kim H, Lee DH, Roh GS, Kim HJ, Kang SS, Choi WS, Cho GJ
- KMID: 1882579
- Anat Cell Biol.
- 2014 Jun;47(2):91-100.
- doi: 10.5115/acb.2014.47.2.91
Excessive immune responses induced by ischemia-reperfusion injury (IRI) are known to lead to necrotic and apoptotic cell death, and calcineurin plays a major role in this process. Calcineurin dephosphorylates the... -
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- The Efficacy of Topical Calcineurin Inhibitors for Treating Lichen Striatus
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Kim GW, Kim SH, Chin HW, Seo SH, Jung DS, Ko HC, Kim MB, Kwon KS
- KMID: 2301940
- Korean J Dermatol.
- 2009 Oct;47(10):1135-1140.
BACKGROUND: Lichen striatus is a well-known, acquired, self-healing, linear inflammatory dermatosis. The therapeutic approach that is usually adopted is topical steroid, even though the prolonged use of this may lead... -
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- Down syndrome critical region 1 enhances the proteolytic cleavage of calcineurin
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Lee JE, Jang H, Cho EJ, Youn HD
- KMID: 1058021
- Exp Mol Med.
- 2009 Jul;41(7):471-477.
- doi: 10.3858/emm.2009.41.7.052
Down syndrome critical region 1 (DSCR1), an oxidative stress-response gene, interacts with calcineurin and represses its phosphatase activity. Recently it was shown that hydrogen peroxide inactivates calcineurin by proteolytic cleavage.... -
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- Chronic urticaria treated with tacrolimus
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Jung HC, Lee DH, Park HS, Lee HJ, Kwon JW
- KMID: 1803549
- Allergy Asthma Respir Dis.
- 2014 Nov;2(5):391-393.
- doi: 10.4168/aard.2014.2.5.391
Cyclosporine is a calcineurin inhibitor which is used to treat antihistamine-resistant chronic urticaria. Unfortunately, some patients cannot use cyclosporine due to its side effects. Tacrolimus is another calcineurin inhibitor with... -
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- Four Cases of Atopic Dermatitis with Topical Tacrolimus Therapy
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Chae KO, Kim HO, Kim CW
- KMID: 2146459
- Korean J Dermatol.
- 2002 Jan;40(1):112-114.
Tacrolimus is a macrolide antibiotic that was isolated from soil microorganism. Its mechanism of action is based on calcineurin inhibition, which results in suppression of antigen-specific T-cell activation and inhibition... -
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- Treatment of Atopic Dermatitis: an Update and Review of the Literature
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Kim TY
- KMID: 1474532
- Pediatr Allergy Respir Dis.
- 2009 Sep;19(3):209-219.
Atopic dermatitis is a chronic, relapsing, inflammatory skin disease, with genetic and environmental backgrounds. Successful management of atopic dermatitis requires a multipronged approach. Management should compromise of a disease-adapted treatment... -
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- Expression and Function of Calcineurin in Inflammatory Arthritis
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Park BH, Yoo SA, Hong KH, Hyoung BJ, Hwang YN, Cho CS, Park W, Kim WU
- KMID: 2167987
- Immune Netw.
- 2006 Mar;6(1):33-41.
- doi: 10.4110/in.2006.6.1.33
BACKGROUND: Calcineurin plays a crucial role in T cell activation, cell growth, apoptosis, and angiogenesis, and its over-expression has been implicated in the pathogenesis of cardiomyopathy and stroke. However, the... -
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- Application of Method to Measure Calcineurin Activity in Healthy Human Volunteers after Cyclosporine Administration
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Lim MS, Seong SJ, Park JH, Seo JJ, Lee J, Lee HW, Yoon YR
- KMID: 2334495
- J Korean Soc Clin Pharmacol Ther.
- 2011 Dec;19(2):109-116.
BACKGROUND: Calcineurin-inhibitors have wide inter-individual variation in drug response. Although therapeutic drug monitoring has been conducted to optimize personalized regimen, toxicity or rejection may occur. In this study, pharmacologic effect... -
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- Impact of calcineurin inhibitors on rat glioma cells viability
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Seong JH, Park WY, Paek JH, Park SB, Han S, Mun KC, Jin K
- KMID: 2449322
- Yeungnam Univ J Med.
- 2019 May;36(2):105-108.
- doi: 10.12701/yujm.2019.00108
BACKGROUND: Although kidney transplantation outcomes have improved dramatically after using calcineurin inhibitors (CNIs), CNI toxicity continues to be reported and the mechanism remains uncertain. Here, we investigated the neurotoxicity of... -
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- Issues on Long-term Management after Liver Transplantation in Children
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Kim KM
- KMID: 1450964
- J Korean Soc Transplant.
- 2011 Sep;25(3):165-168.
- doi: 10.4285/jkstn.2011.25.3.165
With advancements of liver transplantation, the patient's survival improved remarkably. Thus the long-term survivors are increasing especially for the pediatric liver transplantation recipients. Consequently they are facing the challenge of... -
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- Pharmacologic Treatment of Atopic Dermatitis
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Park CW
- KMID: 2184730
- J Korean Med Assoc.
- 2006 Nov;49(11):1046-1053.
- doi: 10.5124/jkma.2006.49.11.1046
Atopic dermatitis (AD) is a chronic inflammatory pruritic skin disease that affects a large number of children and adults in Korea. The treatment of AD requires a comprehensive approach that... -
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- Progression of diabetic nephropathy after successful pancreas transplantation alone: a case report
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Kim Y, Kim DI, Shim JR, Lee TB, Yang KH, Ryu JH, Lee HJ, Choi BH
- KMID: 2468165
- Korean J Transplant.
- 2019 Dec;33(4):146-152.
- doi: 10.4285/jkstn.2019.33.4.146
Pancreas transplantation is the only method that can nearly cure insulin-dependent diabetes mellitus. However, the effect of pancreas transplantation on patients with diabetic nephropathy has recently been considered controversial. In... -
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- Treatment of Primary Glomerulonephritis
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Ihm CG
- KMID: 2267901
- Korean J Med.
- 2013 Jan;84(1):13-18.
Much progress has been made in the elucidation of potential pathogenetic mechanisms of glomerulonephritis such as anti-PLA2R autoantibody in membranous nephropathy and under-galactosylated IgA1 in IgA nephropathy as well as... -
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- A Case of Granuloma Annulare Treated with Topical Photodynamic Therapy
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Park MY, Kim YC
- KMID: 1771564
- Korean J Dermatol.
- 2008 Aug;46(8):1138-1140.
Granuloma annulare is a benign, self-limiting dermatosis of unknown cause, and is characterized by erythematous annular papules and plaques commonly located on the distal or dorsal extremities. Many topical and... -
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- Post-transplant Diabetic Ketoacidosis-two Cases
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Hwang EA, Sung JH, Kang MK, Han SY, Park SB, Kim HC
- KMID: 1889341
- Korean J Nephrol.
- 2002 Sep;21(5):865-869.
Posttransplant diabetes mellitus, a complication due to corticosteroids and the calcineurin inhibitors, cyclosporine and tacrolimus, is commonly regarded as a form of type 2 diabetes mellitus. Diabetes ketoacidosis, which requires... -
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- Tinea Incognito due to Trichophyton rubrum in Atopic Dermatitis Patient
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Kim SY, Youn HJ, Jung HJ, Jung JW, Lee YW, Choe YB, Ahn KJ
- KMID: 1731184
- Korean J Med Mycol.
- 2014 Sep;19(3):59-63.
Tinea incognito is a dermatophytic infection with an atypical clinical presentation caused by previous treatment with topical or systemic steroids, as well as by the topical application of calcineurin inhibitors... -
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