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Transduced Tat-aldose Reductase Protects Hippocampal Neuronal Cells against Oxidative Stress-induced Damage

Cho SB, Eum WS, Shin MJ, Kwon HJ, Park JH, Choi YJ, Park J, Han KH, Kang JH, Kim DS, Cho SW, Kim DW, Choi SY

Aldose reductase (AR) protein, a member of the NADPH-dependent aldo-keto reductase family, reduces a wide range of aldehydes and enhances cell survival by inhibition of oxidative stress. Oxidative stress is...
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Transient forebrain ischemia induces impairment in cognitive performance prior to extensive neuronal cell death in Mongolian gerbil (Meriones unguiculatus)

Kondo T, Yoshida S, Nagai H, Takeshita , Mino M, Morioka H, Nakajima T, Kusakabe K, Okada T

In Mongolian gerbils, bilateral common carotid artery occlusion (BCCAO) for several minutes induces ischemia, due to an incomplete circle of Willis, resulting in delayed neuronal cell death in the Cornet...
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Neuroprotective Effect of Duloxetine on Chronic Cerebral Hypoperfusion-Induced Hippocampal Neuronal Damage

Park JA, Lee CH

Chronic cerebral hypoperfusion (CCH), which is associated with onset of vascular dementia, causes cognitive impairment and neuropathological alterations in the brain. In the present study, we examined the neuroprotective effect...
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Age-dependent differences in myelin basic protein expression in the hippocampus of young, adult and aged gerbils

Ahn JH, Lee TK, Park JH, Cho JH, Kim IH, Lee JC, Hong S, Jeon YH, Kang IJ, Lee YJ, Won MH, Lee CH

Myelin degeneration is one of the characteristics of aging and degenerative diseases. This study investigated age-related alterations in expression of myelin basic protein (MBP) in the hippocampal subregions (dentate gyrus,...
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Neuroprotection of Dexmedetomidine against Cerebral Ischemia-Reperfusion Injury in Rats: Involved in Inhibition of NF-κB and Inflammation Response

Wang L, Liu H, Zhang L, Wang G, Zhang M, Yu Y

Dexmedetomidine is an α2-adrenergic receptor agonist that exhibits a protective effect on ischemia-reperfusion injury of the heart, kidney, and other organs. In the present study, we examined the neuroprotective action...
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Temporal changes in mammalian target of rapamycin (mTOR) and phosphorylated-mTOR expressions in the hippocampal CA1 region of rat with vascular dementia

Park JA, Lee CH

Mammalian target of rapamycin (mTOR) has an important role in various biological processes in cells. In the present study, we investigated temporal changes in mTOR and phosphorylated-mTOR (p-mTOR) expressions in...
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Effects of Modafinil on Behavioral Learning and Hippocampal Synaptic Transmission in Rats

Yan WW, Yao LH, Chen C, Wang HX, Li CH, Huang JN, Xiao P, Liu CY

PURPOSE: Modafinil is a wake-promoting agent that has been proposed to improve cognitive performance at the preclinical and clinical levels. Since there is insufficient evidence for modafinil to be regarded...
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Aucubin Promotes Neurite Outgrowth in Neural Stem Cells and Axonal Regeneration in Sciatic Nerves

Kim YM, Sim UC, Shin Y, Kwon YK

Aucubin is an iridoid glycoside with a wide range of biological activities, including anti-inflammatory, anti-microbial, anti-algesic as well as anti-tumor activities. Recently, it has been shown that aucubin prevents neuronal...
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Increased expression of the receptor for advanced glycation end products in neurons and astrocytes in a triple transgenic mouse model of Alzheimer's disease

Choi BR, Cho WH, Kim J, Lee HJ, Chung C, Jeon WK, Han JS

The receptor for advanced glycation end products (RAGE) has been reported to have a pivotal role in the pathogenesis of Alzheimer's disease (AD). This study investigated RAGE levels in the...
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Characterization of nestin expression in astrocytes in the rat hippocampal CA1 region following transient forebrain ischemia

Cho JM, Shin YJ, Park JM, Kim J, Lee MY

Recent studies have suggested that nestin facilitates cellular structural remodeling in vasculature-associated cells in response to ischemic injury. The current study was designed to investigate the potential role of post-ischemic...
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Protective effects of transduced Tat-DJ-1 protein against oxidative stress and ischemic brain injury

Jeong HJ, Kim DW, Kim MJ, Woo SJ, Kim HR, Kim SM, Jo HS, Hwang HS, Kim DS, Cho SW, Won MH, Han KH, Park J, Eum WS, Choi SY

  • KMID: 1506222
  • Exp Mol Med.
  • 2012 Oct;44(10):586-593.
Reactive oxygen species (ROS) contribute to the development of a number of neuronal diseases including ischemia. DJ-1, also known to PARK7, plays an important role in transcriptional regulation, acting as...
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Neuroprotection of Alpinia katsumadai Seed Extract against Neuronal Damage in the Ischemic Gerbil Hippocampus is Linked to Altered Brain-Derived Neurotrophic Factor

Li H, Park JH, Yan B, Yoo KY, Lee CH, Choi JH, Hwang IK, Won MH

  • KMID: 2391862
  • Lab Anim Res.
  • 2011 Mar;27(1):67-71.
The extract of Alpinia katsumadai, a member of the family Zingiberaceae, shows anti-inflammatory effects and antioxidant activity. We observed the neuroprotective effects of the extract from Alpinia katsumadai seed (EAKS)...
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Expressions of the pERK1/2 and the cFos Proteins at an Early Stage of Transient Global Ischemia-reperfusion Injury in the Hippocampus of Rats

Ko CS, Yun YH, Ahn HC, Choi JW, Wi DH, Yu SJ, Park JH

  • KMID: 2331417
  • J Korean Soc Emerg Med.
  • 2004 Dec;15(6):475-486.
PURPOSE: This study was to evaluate temporal changes in the expressions of the phosphorylated extracellular-regulated kinase1/2 (pERK1/2), the phosphorylated MAPK/ERK kinase1/2 (pMEK1/2) and the cFos proteins in the hippocampus of...
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The Effect of Delayed Administration of Green Tea Polyphenol, (-)-pigallocatechin-3-gallate, on the Change of Putrescine Level and Hippocampal Neuronal Cell Damage after Transient Global Ischemia in Gerbil

Lee SR, Kim SP, Yim MB

  • KMID: 2010306
  • J Korean Neurosurg Soc.
  • 2003 Jan;33(1):67-72.
OBJECTIVE: T(-)-Epigallocatechin gallate(EGCG) `a green tea polyphenol' is a potent antioxidant and known to reduce the free radical-induced lipid peroxidation. In our previous study, systemic administration of EGCG immediately after...
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Effect of Low Dose Radiation on Tran: sient Global Cerebral Ischemia in Gerbils

Park KN, Choi SP, Kim YM, Seo JS, Kim SK

  • KMID: 2194081
  • J Korean Soc Emerg Med.
  • 2002 Jun;13(2):122-128.
PURPOSE: To date, much research has been performed for amelioration of secondary brain damage after cerebral ischemia and reperfusion. We investigated the antioxidative and anti-inflammatory effects of post-ischemic low-dose total-body...
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Nip2 Expression of Postnatal, Aged and Transient Focal Cerebral Ischemic Rat

Kim YT, Lee WK, Lee YI, Lee JG, Park HC, Jin KS

  • KMID: 2092801
  • Korean J Anat.
  • 2002 Dec;35(6):543-550.
Nip2 mRNA expression of hippocampus was clarified in the postnatal, adult and aging rat. We observed the change of Nip2 mRNA expression in the ischemic rat hippocampus at 3, 6,...
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Changes of Glutamate Receptor Subunit Gene Expression in the Rat Hippocampus following Global Cerebral Ischemia

Lee SH, Kim JK, Bae CS, Chung YY, Cho KH

  • KMID: 2274988
  • Chonnam Med J.
  • 2001 Sep;37(3):219-224.
It has been well known that transient global ischemia of the brain induces delayed neuronal death of hippicampal CA1 pyramidal cells. Calcium influx is thought to play a critical role...
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Immunocytochemical Study on the Changes of Cell-Death Controlling Factors in the Hippocampal Formation and Entorhinal Cortex of Aged Rats

Shin SJ, Woo HW

  • KMID: 2340569
  • J Korean Neuropsychiatr Assoc.
  • 2001 May;40(3):520-533.
OBJECTIVES: Hippocampal formation and entorhinal cortex play a part in learning and memory. This study sought to investigate the change of cell-death controlling factors in the hippocampal formation and entorhinal...
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Differential inhibitory action of taurine between electrically evoked response and low Mg++/-induced spontaneous activity in the CA1 area of the rat hippocampal slices

Baek SY, Yang SG, Lee CJ

  • KMID: 1554756
  • Korean J Physiol Pharmacol.
  • 1997 Oct;1(5):467-475.
Although one of the major physiological functions of taurine (2-aminoethanesulfonic acid) is the inhibitory action on the central nervous system (CNS), the mechanism of taurine in controlling the neuronal excitation in the CNS...
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The protective effect of Cortical Infarction to the Neuronal damage following subsequent global ischemic insult in gebril

Yu KH, Lee BC, Lee BI, Ku HS

  • KMID: 2342501
  • J Korean Neurol Assoc.
  • 1996 Jun;14(2):319-330.
Prior brief ischemic insult was reported to protect the hippocampal CA1 neurons from delayed neuronal death following global ischemia. Mechanisms of such protective effects have, however, remained unclear. The study...
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