- Rosiglitazone, a Peroxisome Proliferator-Activated Receptor-gamma Agonist, Restores Alveolar and Pulmonary Vascular Development in a Rat Model of Bronchopulmonary Dysplasia
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Lee HJ, Lee YJ, Choi CW, Lee JA, Kim EK, Kim HS, Kim BI, Choi JH
- KMID: 1779892
- Yonsei Med J.
- 2014 Jan;55(1):99-106.
- doi: 10.3349/ymj.2014.55.1.99
PURPOSE: We tested whether rosiglitazone (RGZ), a peroxisome proliferator-activated receptor-gamma agonist, can restore alveolar development and vascular growth in a rat model of bronchopulmonary dysplasia (BPD). MATERIALS AND METHODS: A rat... -
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- Deferoxamine Improves Alveolar and Pulmonary Vascular Development by Upregulating Hypoxia-inducible Factor-1alpha in a Rat Model of Bronchopulmonary Dysplasia
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Choi CW, Lee J, Lee HJ, Park HS, Chun YS, Kim BI
- KMID: 2344155
- J Korean Med Sci.
- 2015 Sep;30(9):1295-1301.
- doi: 10.3346/jkms.2015.30.9.1295
Fetal lung development normally occurs in a hypoxic environment. Hypoxia-inducible factor (HIF)-1alpha is robustly induced under hypoxia and transactivates many genes that are essential for fetal development. Most preterm infants... -
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