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Pharmacotherapy for chronic obstructive pulmonary disease

Jo YS, Park YB

Appropriate pharmacologic therapy can reduce symptoms and risk and severity of exacerbations, as well as improve the health status and exercise tolerance of patients with chronic obstructive pulmonary disease. The...
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Treatment and prevention of acute exacerbation of chronic obstructive pulmonary disease

Lim SY, Kim HJ, Ra SW, Lee JH, Kim TH

Acute exacerbation of chronic obstructive pulmonary disease (COPD) is defined as an acute aggravation of the patient's respiratory symptoms, particularly cough, sputum production, and dyspnea, which requires a change of...
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Pharmacotherapy for chronic obstructive pulmonary disease

Kim IA, Park YB, Yoo KH

The goals of management of stable chronic obstructive pulmonary disease (COPD) are to reduce both current symptoms and future risks with minimal side effects from treatment. Identification and reduction of...
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Optimal Bronchodilation for COPD Patients: Are All Long-Acting β₂-Agonist/Long-Acting Muscarinic Antagonists the Same?

Miravitlles M, Baek S, Vithlani V, Lad R

Bronchodilators provide improvements in lung function and reductions in symptoms and exacerbations, and are the mainstay of pharmacological management of chronic obstructive pulmonary disease (COPD). The Global Initiative for Chronic...
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What Can We Apply to Manage Acute Exacerbation of Chronic Obstructive Pulmonary Disease with Acute Respiratory Failure?

Kim DK, Lee J, Park JH, Yoo KH

Acute exacerbation(s) of chronic obstructive pulmonary disease (AECOPD) tend to be critical and debilitating events leading to poorer outcomes in relation to chronic obstructive pulmonary disease (COPD) treatment modalities, and...
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Positioning of Long-Acting Muscarinic Antagonists in the Management of Asthma

Aalbers R, Park HS

Despite a range of efficacious therapies for asthma, including inhaled corticosteroids (ICS) and long-acting β₂-agonists (LABA), a significant proportion of patients have poor asthma control and retain a risk of...
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Spirometry and Bronchodilator Test

Sim YS, Lee JH, Lee WY, Suh DI, Oh YM, Yoon JS, Lee JH, Cho JH, Kwon CS, Chang JH

Spirometry is a physiological test for assessing the functional aspect of the lungs using an objective indicator to measure the maximum amount of air that a patient can inhale and...
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Safety and Effectiveness of Indacaterol in Chronic Obstructive Pulmonary Disease Patients in South Korea

Yum HK, Kim HR, Chang YS, Shin KC, Kim S, Oh YM

BACKGROUND: Inhaled indacaterol (Onbrez Breezhaler), a long-acting β₂-agonist, is approved in over 100 countries, including South Korea, as a once-daily bronchodilator for maintenance and treatment of chronic obstructive pulmonary disease...
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Does the different amount of short-acting bronchodilator drugs have different effects on small airway response in bronchodilator test?

Baek JH, Jang H, Jeon YH, Seo BS, Lee SJ, Jee HM, Lee KS, Jung YH, Sheen YH, Han MY

PURPOSE: It is recommended to use 200 (2 puffs) or 400 (4 puffs) µg of salbutamol in the bronchodilator response (BDR) test. We aimed to compare the difference between these...
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The effects of daily bathing on symptoms of patients with bronchial asthma

Kamimura M, Arimoto Y, Homma C, Takeoka S, Fukusumi M, Mouri A, Hamamoto Y

BACKGROUND: The influence of bathing in asthma patients is not yet fully known. OBJECTIVE: We conducted an observational study to investigate changes in symptoms and their degree by bathing in asthmatic...
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The Role of Bronchodilators in Preventing Exacerbations of Chronic Obstructive Pulmonary Disease

Beeh KM

Bronchodilators are the cornerstone of symptomatic chronic obstructive pulmonary disease (COPD) treatment. They are routinely recommended for symptom reduction, with a preference of long-acting over short-acting drugs. Bronchodilators are classified...
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Phenotype of asthma-chronic obstructive pulmonary disease overlap syndrome

Rhee CK

Many patients with asthma or chronic obstructive pulmonary disease (COPD) have overlapping characteristics of both diseases. By spirometric definition, patients with both fixed airflow obstruction (AO) and bronchodilator reversibility or...
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Effect of Indacaterol on Cough and Phlegm in Chronic Obstructive Pulmonary Disease Patients: A Meta-Analysis of Five Randomized Controlled Trials

Park J, Lee JS, Rhee C, Oh YM

We investigated the effects of indacaterol on cough and phlegm in patients with stable chronic obstructive pulmonary disease (COPD). We performed a meta-analysis with five randomized controlled trials (RCTs) of...
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Three-month Treatment Response and Exacerbation in Chronic Obstructive Pulmonary Disease

Lee JS, Rhee CK, Yoo KH, Lee JH, Yoon HI, Kim TH, Kim WJ, Lee J, Lim SY, Park TS, Lee JS, Lee SW, Lee SD, Oh YM

The aim of this study was to investigate relationships between acute exacerbation and Forced Expiratory Volume 1 second (FEV1) improvement after treatment with combined long-acting beta-agonist (LABA) and inhaled corticosteroid...
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Clinical Manifestations, Management, and Natural Course of Infants with Recurrent Bronchiolitis or Reactive Airways Disease

Park HJ, Kim JH, Chun YH, Lee SY, Kim SY, Kang JH

  • KMID: 1705185
  • Korean J Pediatr Infect Dis.
  • 2014 Apr;21(1):37-42.
PURPOSE: The purpose of this study was to investigate the clinical manifestations and 5-year natural course of recurrent bronchiolitis or reactive airways disease (RAD) in infants. METHODS: We reviewed the medical...
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Fractional Exhaled Nitric Oxide and Impulse Oscillometry in Children With Allergic Rhinitis

Kim YH, Park HB, Kim MJ, Kim HS, Lee HS, Han YK, Kim KW, Sohn MH, Kim KE

PURPOSE: Airway inflammation, bronchial hyper-responsiveness (BHR), and bronchodilator response (BDR) are representative characteristics of asthma. Because allergic rhinitis (AR) is a risk factor for asthma development, we evaluated these 3...
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Relationships between Fraction of Nitric Oxide, Airway Hyperresponsiveness, Blood Eoshinophil Counts and Serum Eosinophil Cationic Protein in Asthmatic Children

Seo HS, Chung BH, Park HN, Seo SC, Siegfried , Song DJ, Choung JT, Yoo Y

  • KMID: 2315275
  • Pediatr Allergy Respir Dis.
  • 2012 Sep;22(3):282-291.
PURPOSE: The measurement of fraction of nitric oxide (FeNO) is a noticeable tool that reflects airway inflammation in asthmatic patients. We wanted to find out the relationship between pulmonary function,...
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Suspected Anaphylactic Reaction Associated with Microemulsion Propofol during Anesthesia Induction

Lee SJ, Kim SI, Jung BI, Lee SM, Kim MG, Park SY, Kim SH, Ok SY

Although rare, intraoperative anaphylaxis can lead to significant morbidity and mortality. Aquafol(R) (Daewon Pharmaceutical Co. Ltd., Seoul, Korea), a microemulsion propofol, was developed to eliminate lipid solvent-related adverse events, and...
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The role of tiotropium in the management of asthma

Park HW

Asthma is a chronic respiratory disease characterized by reversible airway obstruction that is secondary to an allergic inflammation and excessive smooth muscle contraction. Cholinergic signals were known to contribute significantly...
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Changes in the Indices of Bronchial Reversibility Assessed by the Office Spirometry and Their Relationship to Asthma Symptoms after Discontinuing Controller Medication in Children with Controlled Asthma: Pilot Study

Lee EJ, Kim KH, Lee JK, Song JH, Park JD, Koh YY, Suh DI

  • KMID: 2315297
  • Pediatr Allergy Respir Dis.
  • 2012 Dec;22(4):336-343.
PURPOSE: It is important to assess the level of control in asthmatic children who were well-controlled and thus discontinued controller medications. Office spirometry has been regarded to provide objective measures....
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