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Inactivated pep27 mutant as an effective mucosal vaccine against a secondary lethal pneumococcal challenge in mice

Choi SY, Tran TD, Briles DE, Rhee DK

  • KMID: 2391977
  • Clin Exp Vaccine Res.
  • 2013 Jan;2(1):58-65.
PURPOSE: A pep27 mutant may be able to elicit mucosal immunity against pneumococcal diseases, and could be employed as an inexpensive attenuated vaccine. However, this particular mutant contains an erythromycin-resistance...
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A Molecular Mucosal Adjuvant To Enhance Immunity Against Pneumococcal Infection In The Elderly

Fukuyama Y, Ikeda Y, Ohori J, Sugita G, Aso K, Fujihashi , Briles DE, McGhee JR, Fujihashi

Streptococcus pneumoniae (the pneumococcus) causes a major upper respiratory tract infection often leading to severe illness and death in the elderly. Thus, it is important to induce safe and effective...
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