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Comparative Effects of Ibandronate and Paclitaxel on Immunocompetent Bone Metastasis Model

Chung YS, Kang HC, Lee T

PURPOSE: Bone metastasis invariably increases morbidity and mortality. This study compares the effects of ibandronate and paclitaxel on bone structure and its mechanical properties and biochemical turnover in resorption markers...
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Pathological responses to preoperative high-dose methotrexate chemotherapy in osteosarcoma: experience in Korea cancer hospital

Lee SY, Jeon DG, Kim SS, Jang JJ, Cho KJ

During the last decade, many clinical investigators at various cancer centers have reported the efficacy of various chemotherapeutic agents in the treatment of osteosarcoma. The regimens using high-dose methotrexate (HDMTX)...
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Bisphosphonate enhances TRAIL sensitivity to human osteosarcoma cells via death receptor 5 upregulation

Moon MH, Jeong JK, Seo JS, Seol JW, Lee YJ, Xue M, Jackson CJ, Park SY

Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL), a member of the TNF superfamily of cytokines, is one of the most promising candidates for cancer therapeutics. However, many osteosarcomas are resistant...
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Long-Term Survivals of Stage IIB Osteosarcoma: A 20-Year Experience in a Single Institution

Cho Y, Jung GH, Chung SH, Kim JY, Choi Y, Kim JD

BACKGROUND: The purpose of this study is to evaluate the disease-free survival (DFS) and overall survival (OS) of patients with stage IIB osteosarcoma at a single institution for 20 years...
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