- Emerging and Promising Keywords in Biomolecules and Therapeutics for 21st Century Diseases
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Ko HJ, Lee CH
- KMID: 2563804
- Biomol Ther.
- 2025 Jan;33(1):1-4.
- doi: 10.4062/biomolther.2024.007
Recent technological advancements and environmental changes are leading to an increase in various diseases such as obesity, fibrosis, metabolic disorders, and degenerative diseases associated with aging. Additionally, micro- and nanoplastics... -
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- Erratum to "Abiraterone Acetate Attenuates SARS-CoV-2 Replication by Interfering with the Structural Nucleocapsid Protein"
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Kim J, Hwang SY, Kim D, Kim M, Baek K, Kang M, An S, Gong J, Park S, Kandeel M, Lee Y, Noh M, Kwon HJ
- KMID: 2563823
- Biomol Ther.
- 2025 Jan;33(1):231-232.
- doi: 10.4062/biomolther.2024.005
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- The Emerging Threat of Micro- and Nanoplastics on the Maturation and Activity of Immune Cells
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Dan KB, Yoo JY, Min H
- KMID: 2563811
- Biomol Ther.
- 2025 Jan;33(1):95-105.
- doi: 10.4062/biomolther.2024.195
With the increasing use of plastics worldwide, the amount of plastic waste being discarded has also risen. This plastic waste undergoes physical and chemical processes, breaking down into smaller particles... -
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- Erratum to "Investigating the Immune-Stimulating Potential of β-Glucan from Aureobasidium pullulans in Cancer Immunotherapy" [Biomol Ther 32(5), 556-567 (2024)]
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Jeong JH, Kim DJ, Hong SJ, Ahn JH, Lee DJ, Jang AR, Kim S, Cho HJ, Lee JY, Park JH, Kim YM, Ko HJ
- KMID: 2563824
- Biomol Ther.
- 2025 Jan;33(1):233-233.
- doi: 10.4062/biomolther.2024.006
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- An Overview of Existing and Emerging Weight-Loss Drugs to Target Obesity-Related Complications: Insights from Clinical Trials
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Kim MK, Kim HS
- KMID: 2563805
- Biomol Ther.
- 2025 Jan;33(1):5-17.
- doi: 10.4062/biomolther.2024.228
Obesity requires treatment as it is associated with health problems such as type 2 diabetes, hypertension, dyslipidemia, cardiovascular diseases, and some cancers, which increase mortality rates. Achieving sufficient weight loss... -
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- The Anti-Inflammatory Activities of Benzylideneacetophenone Derivatives in LPS Stimulated BV2 Microglia Cells and Mice
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Kim M, Kang S, Oh S
- KMID: 2563812
- Biomol Ther.
- 2025 Jan;33(1):106-116.
- doi: 10.4062/biomolther.2024.049
A previously reported study highlighted the neuroprotective potential of the novel benzylideneacetophenone derivative, JC3, in mice. In pursuit of compounds with even more robust neuroprotective and anti-inflammatory properties compared to... -
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- Probiotics as Potential Treatments for Neurodegenerative Diseases: a Review of the Evidence from in vivo to Clinical Trial
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Kim JH, Choi Y, Lee S, Oh MS
- KMID: 2563808
- Biomol Ther.
- 2025 Jan;33(1):54-74.
- doi: 10.4062/biomolther.2024.215
Neurodegenerative diseases (NDDs), characterized by the progressive deterioration of the structure and function of the nervous system, represent a significant global health challenge. Emerging research suggests that the gut microbiota... -
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- Natural Compounds in Kidney Disease: Therapeutic Potential and Drug Development
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Natesan V, Kim SJ
- KMID: 2563807
- Biomol Ther.
- 2025 Jan;33(1):39-53.
- doi: 10.4062/biomolther.2024.142
Diabetic kidney disease (DKD) poses a major global health challenge, affecting millions of individuals and contributing to substantial morbidity and mortality. Traditional treatments have focused primarily on managing symptoms and... -
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- The Dual Role of Survival Genes in Neurons and Cancer Cells: a Strategic Clinical Application of DX2 in Neurodegenerative Diseases and Cancer
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Baek K
- KMID: 2563809
- Biomol Ther.
- 2025 Jan;33(1):75-85.
- doi: 10.4062/biomolther.2024.138
In cancer cells, survival genes contribute to uncontrolled growth and the survival of malignant cells, leading to tumor progression. Neurons are post-mitotic cells, fully differentiated and non-dividing after neurogenesis and survival... -
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- C-Peptide Ameliorates Particulate Matter 2.5-Induced Skin Cell Apoptosis by Inhibiting NADPH Oxidation
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Fernando PDSM, Piao MJ, Herath HMUL, Kang KA, Ha KS, Chae S, Hyun JW
- KMID: 2563822
- Biomol Ther.
- 2025 Jan;33(1):221-230.
- doi: 10.4062/biomolther.2024.053
Connecting peptide (C-peptide), a byproduct of insulin biosynthesis, has diverse cellular and biological functions. Particulate mat- ter 2.5 (PM2.5 ) adversely affects human skin, leading to skin thickening, wrinkle formation, skin... -
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- Combination of Cannabidiol with Taurine Synergistically Treated Periodontitis in Rats
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Kim SW, Shrestha SK, Chuluunbaatar BA, Soh Y
- KMID: 2563820
- Biomol Ther.
- 2025 Jan;33(1):203-209.
- doi: 10.4062/biomolther.2024.104
The active component in cannabis, cannabidiol (CBD), was first isolated from the hemp plant in 1940. Chronic pain, inflammation, migraines, depression, and anxiety have long been treated with CBD. The... -
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- Translationally Controlled Tumor Protein Enhances Angiogenesis in Ovarian Tumors by Activating Vascular Endothelial Growth Factor Receptor 2 Signaling
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Rho SB, Kim BR, Lee SH, Lee CH
- KMID: 2563819
- Biomol Ther.
- 2025 Jan;33(1):193-202.
- doi: 10.4062/biomolther.2024.206
Translationally controlled tumor protein (TCTP) is a regulatory protein that plays pivotal roles in cellular processes including the cell cycle, apoptosis, microtubule stabilization, embryo development, stress responses, and cancer. However,... -
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- Intra-Articular Injection of Stem Cells for the Regeneration of Knee Joint Cartilage: a Therapeutic Option for Knee Osteoarthritis — a Narrative Review
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Lee HJ, Hossain R, Baek CH, Lee CJ, Hwang SC
- KMID: 2563810
- Biomol Ther.
- 2025 Jan;33(1):86-94.
- doi: 10.4062/biomolther.2024.139
Current approaches to regulating osteoarthritis primarily focus on symptom management; however, these methods often have significant side effects and may not be suitable for long-term care. As an alternative to... -
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- New Insights into AMPK, as a Potential Therapeutic Target in Metabolic Dysfunction-Associated Steatotic Liver Disease and Hepatic Fibrosis
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An H, Jang Y, Choi J, Hur J, Kim S, Kwon Y
- KMID: 2563806
- Biomol Ther.
- 2025 Jan;33(1):18-38.
- doi: 10.4062/biomolther.2024.188
AMP-activated protein kinase (AMPK) activators have garnered significant attention for their potential to prevent the progression of metabolic dysfunction-associated steatotic liver disease (MASLD) into liver fibrosis and to fundamentally improve... -
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- Taurine Synthesis by 2-Aminoethanethiol Dioxygenase as a Vulnerable Metabolic Alteration in Pancreatic Cancer
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Nam H, Lee W, Lee YJ, Kim JM, Jung KH, Hong SS, Kim SC, Park S
- KMID: 2563815
- Biomol Ther.
- 2025 Jan;33(1):143-154.
- doi: 10.4062/biomolther.2024.086
Pancreatic ductal adenocarcinoma (PDAC) exhibits an altered metabolic profile compared to normal pancreatic tissue. However, studies on actual pancreatic tissues are limited. Untargeted metabolomics analysis was conducted on 54 pairs... -
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- Tanshinone, a Natural NADPH Oxidase Inhibitor, Mitigates Testosterone-Induced Hair Loss
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Hur YK, Chae JY, Choi MH, Park K, Bae DW, Park SB, Cha SS, Lee HE, Lee IH, Bae YS
- KMID: 2563821
- Biomol Ther.
- 2025 Jan;33(1):210-220.
- doi: 10.4062/biomolther.2024.097
Previous studies have shown that testosterone activates the GPRC6A-Duox1 axis, resulting in the production of H 2O 2 which leads to the apoptosis of keratinocytes and ultimately hair loss. Here,... -
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- Low-Dose Perifosine, a Phase II Phospholipid Akt Inhibitor, Selectively Sensitizes Drug-Resistant ABCB1-Overexpressing Cancer Cells
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Park JH, Lee H, Zheng T, Shin JK, Yoon S, Kim HS
- KMID: 2563817
- Biomol Ther.
- 2025 Jan;33(1):170-181.
- doi: 10.4062/biomolther.2024.069
We identified drugs or mechanisms targeting ABCB1 (or P-glycoprotein; P-gp)-overexpressing drug-resistant cancer populations, given that these cells play a key role in tumor recurrence. Specifically, we searched for Akt inhibitors... -
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- 6-Gingerol Induced Apoptosis and Cell Cycle Arrest in Glioma Cells via MnSOD and ERK Phosphorylation Modulation
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Lim SW, Chen WC, Ko HJ, Su YF, Wu CH, Huang FL, Li CF, Tsai CY
- KMID: 2563814
- Biomol Ther.
- 2025 Jan;33(1):129-142.
- doi: 10.4062/biomolther.2024.084
6-gingerol, a bioactive compound from ginger, has demonstrated promising anticancer properties across various cancer models by inducing apoptosis and inhibiting cell proliferation and invasion. In this study, we explore its... -
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- Epigenetic Regulation of Nuclear Factor Erythroid-2-Related Factor 2 in Colorectal Cancer Cells Resistant to Ionizing Radiation
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Kang KA, Park J, Piao MJ, Fernando PDSM, Herath HMUL, Senavirathna HMMM, Kim JH, Cho SJ, Hyun JW
- KMID: 2563818
- Biomol Ther.
- 2025 Jan;33(1):182-192.
- doi: 10.4062/biomolther.2024.183
γ-Radiation resistance is a major obstacle to the success of radiotherapy in colorectal cancer. Antioxidant-related factors contribute to resistance to radiation therapy and, therefore, are targets for improving the therapeutic... -
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- Glutathione’s Role in Liver Metabolism and Hangover Symptom Relief: Dysregulation of Protein S-Glutathionylation and Antioxidant Enzymes
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Lee HY, Lee GH, Kim DS, Lim YJ, Cho B, Jung H, Choi Hs, Sa S, Chung W, Lee H, Chung MJ, Kim J, Chae HJ
- KMID: 2563813
- Biomol Ther.
- 2025 Jan;33(1):117-128.
- doi: 10.4062/biomolther.2024.182
Hangovers from alcohol consumption cause symptoms like headaches, nausea, and fatigue, disrupting daily activities and overall well-being. Over time, they can also lead to inflammation and oxidative stress. Effective hangover... -
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