Biomol Ther.  2025 Jan;33(1):95-105. 10.4062/biomolther.2024.195.

The Emerging Threat of Micro- and Nanoplastics on the Maturation and Activity of Immune Cells

• Dan KB
• Yoo JY
• Min H

• KMID: 2563811
• DOI: http://doi.org/10.4062/biomolther.2024.195

Abstract

With the increasing use of plastics worldwide, the amount of plastic waste being discarded has also risen. This plastic waste undergoes physical and chemical processes, breaking down into smaller particles known as microplastics (MPs) or nanoplastics (NPs). Advances in technology have enhanced our ability to detect these smaller particles, and it has been confirmed that plastics can be found in marine organisms as well as within the human body. However, research on the effects of MPs or NPs on living organisms has only recently been started, and our understanding remains limited. Studies on the immunological impacts are still ongoing, revealing that MPs and NPs can differentially affect various immune cells based on the material, size, and shape of the plastic particles. In this review, we aim to provide a comprehensive understanding of the effects of MPs and NPs on the immune system. We will also explore the methods for plastic removal through physicochemical, microbial, or biological means.

Keyword

Microplastic; Nanoplastic; Immune cell; Myeloid cell; Lymphoid cell