- Glycogen Phosphorylase Inhibitor Promotes Hair Growth via Protecting from Oxidative-Stress and Regulating Glycogen Breakdown in Human Hair follicles
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Park B, Kim D, Zhao H, Kim S, Park BC, Lee S, Lee Y, Park HD, Lim D, Ryu S, Hwang JS
- KMID: 2559254
- Biomol Ther.
- 2024 Sep;32(5):640-646.
- doi: 10.4062/biomolther.2024.098
Hair growth cycles are mainly regulated by human dermal papilla cells (hDPCs) and human outer root sheath cells (hORSCs). Protecting hDPCs from excessive oxidative stress and hORSCs from glycogen phosphorylase (PYGL)... -
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- Carnosine and Retinol Synergistically Inhibit UVB-Induced PGE2 Synthesis in Human Keratinocytes through the Up-Regulation of Hyaluronan Synthase 2
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Park IG, Jin SH, An S, Ki MW, Park WS, Kim HJ, Na Y, Noh M
- KMID: 2559253
- Biomol Ther.
- 2024 Sep;32(5):635-639.
- doi: 10.4062/biomolther.2023.226
Skin aging results from complex interactions of intrinsic and extrinsic factors, leading to structural and biochemical changes such as wrinkles and dryness. Ultraviolet (UV) irradiation leads to the degradation of... -
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- Pyronaridine Inhibited MUC5AC Mucin Gene Expression by Regulation of Nuclear Factor Kappa B Signaling Pathway in Human Pulmonary Mucoepidermoid Cells
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Hossain R, Lee HJ, Lee CJ
- KMID: 2559243
- Biomol Ther.
- 2024 Sep;32(5):540-545.
- doi: 10.4062/biomolther.2024.072
In this study, the potential effects of pyronaridine, an antimalarial agent, on airway MUC5AC mucin gene expression were investigated. The human pulmonary epithelial NCI-H292 cells were pretreated with pyronaridine for... -
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- Gilteritinib Reduces FLT3 Expression in Acute Myeloid Leukemia Cells
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Thái TL, Han SY
- KMID: 2559247
- Biomol Ther.
- 2024 Sep;32(5):577-581.
- doi: 10.4062/biomolther.2023.215
Acute myeloid leukemia (AML) is a genetically diverse and challenging malignancy, with mutations in the FLT3 gene being particularly common and deleterious. Gilteritinib, a potent FLT3 inhibitor, has been approved... -
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- β-Lapachone Exerts Hypnotic Effects via Adenosine A1 Receptor in Mice
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Lee DH, Jee HJ, Jung YS
- KMID: 2559242
- Biomol Ther.
- 2024 Sep;32(5):531-539.
- doi: 10.4062/biomolther.2024.106
Sleep is one of the most essential physiological phenomena for maintaining health. Sleep disturbances, such as insomnia, are often accompanied by psychiatric or physical conditions such as impaired attention, anxiety,... -
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- Decellularized Matrices for the Treatment of Tissue Defects: from Matrix Origin to Immunological Mechanisms
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Wang X, Guo J, Yu Q, Zhao L, Gao X, Wang L, Wen M, Yan J, An M, Liu Y
- KMID: 2559240
- Biomol Ther.
- 2024 Sep;32(5):509-522.
- doi: 10.4062/biomolther.2024.050
Decellularized matrix transplantation has emerged as a promising therapeutic approach for repairing tissue defects, with numerous studies assessing its safety and efficacy in both animal models and clinical settings. The... -
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- Loganin Ameliorates Acute Kidney Injury and Restores Tofacitinib Metabolism in Rats: Implications for Renal Protection and Drug Interaction
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Choi HG, Park SY, Bae SH, Chang SY, Kim SH
- KMID: 2559250
- Biomol Ther.
- 2024 Sep;32(5):601-610.
- doi: 10.4062/biomolther.2024.008
Tofacitinib, a Janus kinase (JAK) inhibitor used to treat rheumatoid arthritis, is metabolized through hepatic cytochrome P450 (CYP), specifically CYP3A1/2 and CYP2C11. Prolonged administration of rheumatoid arthritis medications is generally... -
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- Interleukin-1β Signaling Contributes to Cell Cycle Arrest and Apoptotic Cell Death by Leptin via Modulation of AKT and p38MAPK in Hepatocytes
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Baral A, Park PH
- KMID: 2559251
- Biomol Ther.
- 2024 Sep;32(5):611-626.
- doi: 10.4062/biomolther.2023.232
Leptin, an adipose tissue-derived hormone, has exhibited the potent hepatotoxic effects. However, the underlying molecular mechanisms are not fully understood. In this study, we have elucidated the mechanisms by which... -
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- Coadministration of 6-Shogaol and Levodopa Alleviates Parkinson’s Disease-Related Pathology in Mice
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Kim JH, Kim JS, Ju IG, Huh E, Choi Y, Lee S, Cho JY, Park BY, Oh MS
- KMID: 2559241
- Biomol Ther.
- 2024 Sep;32(5):523-530.
- doi: 10.4062/biomolther.2024.075
Parkinson’s disease (PD) is a neurodegenerative disease caused by the death of dopaminergic neurons in the nigrostriatal pathway, leading to motor and non-motor dysfunctions, such as depression, olfactory dysfunction, and... -
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- Domperidone, a Dopamine Receptor D2 Antagonist, Induces Apoptosis by Inhibiting the ERK/STAT3-Mediated Pathway in Human Colon Cancer HCT116 Cells
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Sim SJ, Jang JH, Choi JS, Chun KS
- KMID: 2559246
- Biomol Ther.
- 2024 Sep;32(5):568-576.
- doi: 10.4062/biomolther.2024.048
Colorectal cancer (CRC) continues to demonstrate high incidence and mortality rates, emphasizing that implementing strategic measures for prevention and treatment is crucial. Recently, the dopamine receptor D2 (DRD2), a G... -
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- Unraveling Stereochemical Structure-Activity Relationships of Sesquiterpene Lactones for Inhibitory Effects on STAT3 Activation
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An S, Chun J, Lee J, Kim YS, Noh M, Ko H
- KMID: 2559252
- Biomol Ther.
- 2024 Sep;32(5):627-634.
- doi: 10.4062/biomolther.2023.210
Sesquiterpene lactones, a class of natural compounds abundant in the Asteraceae family, have gained attention owing to their diverse biological activities, and particularly their anti-proliferative effects on human cancer cells.... -
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- Investigating the Immune-Stimulating Potential of β-Glucan from Aureobasidium pullulans in Cancer Immunotherapy
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Jeong JH, Kim DJ, Hong SJ, Ahn JH, Lee DJ, Jang AR, Kim S, Cho HJ, Lee JY, Park JH, Kim YM, Ko HJ
- KMID: 2559245
- Biomol Ther.
- 2024 Sep;32(5):556-567.
- doi: 10.4062/biomolther.2024.047
β-glucan, a polysaccharide found in various sources, exhibits unique physicochemical properties, yet its high polymerization limits clinical applications because of its solubility. Addressing this limitation, we introduce PPTEE-glycan, a highly... -
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- Inhibition of Tumoral VISTA to Overcome TKI Resistance via Downregulation of the AKT/mTOR and JAK2/STAT5 Pathways in Chronic Myeloid Leukemia
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Ai K, Chen M, Liang Z, Ding X, Gao Y, Zhang H, Wu S, He Y, Li Y
- KMID: 2559249
- Biomol Ther.
- 2024 Sep;32(5):582-600.
- doi: 10.4062/biomolther.2024.017
Tyrosine kinase inhibitors (TKIs) have revolutionized the treatment landscape for chronic myeloid leukemia (CML). However, TKI resistance poses a significant challenge, leading to treatment failure and disease progression. Resistance mechanisms... -
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- The Combination of Gefitinib and Acetaminophen Exacerbates Hepatotoxicity via ROS-Mediated Apoptosis
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Xu J, Huang X, Zhou Y, Xu Z, Cai X, Yang B, He Q, Luo P, Yan H, Jin J
- KMID: 2559255
- Biomol Ther.
- 2024 Sep;32(5):647-657.
- doi: 10.4062/biomolther.2023.209
Gefitinib is the well-tolerated first-line treatment of non-small cell lung cancer. As it needs analgesics during oncology treatment, particularly in the context of the coronavirus disease, where patients are more... -
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- Aromadendrin Inhibits Lipopolysaccharide-Induced Inflammation in BEAS-2B Cells and Lungs of Mice
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Lee J, Park JW, Choi J, Yun SH, Rhee BH, Jeong HJ, Kim H, Lee K, Ahn KS, Jeong HG, Lee JW
- KMID: 2559244
- Biomol Ther.
- 2024 Sep;32(5):546-555.
- doi: 10.4062/biomolther.2024.022
Aromadendrin is a phenolic compound with various biological effects such as anti-inflammatory properties. However, its protective effects against acute lung injury (ALI) remain unclear. Therefore, this study aimed to explore... -
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