- Modulation of Reactive Oxygen Species to Overcome 5-Fluorouracil Resistance
-
Chun KS, Joo SH
- KMID: 2534697
- Biomol Ther.
- 2022 Nov;30(6):479-489.
- doi: 10.4062/biomolther.2022.017
5-Fluorouracil (5-FU) remains to be an important chemotherapeutic drug for treating several cancers when targeted therapy is unavailable. Chemoresistance limits the clinical utility of 5-FU, and new strategies are required... -
- CITED
-
- Close
- SHARE
-
- Close
- Senotherapeutics and Their Molecular Mechanism for Improving Aging
-
Park J, Shin DW
- KMID: 2534698
- Biomol Ther.
- 2022 Nov;30(6):490-500.
- doi: 10.4062/biomolther.2022.114
Aging is defined as physiological dysfunction of the body and a key risk factor for human diseases. During the aging process, cellular senescence occurs in response to various extrinsic and... -
- CITED
-
- Close
- SHARE
-
- Close
- Effects of Dextran Sulfate Sodium-Induced Ulcerative Colitis on the Disposition of Tofacitinib in Rats
-
Bae SH, Kim HS, Choi HG, Chang SY, Kim SH
- KMID: 2534700
- Biomol Ther.
- 2022 Nov;30(6):510-519.
- doi: 10.4062/biomolther.2022.049
Tofacitinib, a Janus kinase 1 and 3 inhibitor, is mainly metabolized by CYP3A1/2 and CYP2C11 in the liver. The drug has been approved for the chronic treatment of severe ulcerative... -
- CITED
-
- Close
- SHARE
-
- Close
- Synthetic Homoisoflavane Derivatives of Cremastranone Suppress Growth of Colorectal Cancer Cells through Cell Cycle Arrest and Induction of Apoptosis
-
Shin HE, Lee S, Choi Y, Park S, Kwon S, Choi JK, Seo SY, Lee Y
- KMID: 2534708
- Biomol Ther.
- 2022 Nov;30(6):576-584.
- doi: 10.4062/biomolther.2022.090
Colorectal cancer is diagnosed as the third most prevalent cancer; thus, effective therapeutic agents are urgently required. In this study, we synthesized six homoisoflavane derivatives of cremastranone and investigated their... -
- CITED
-
- Close
- SHARE
-
- Close
- Protective Role of Corticosterone against Hydrogen Peroxide-Induced Neuronal Cell Death in SH-SY5Y Cells
-
Lee C, Jang JH, Park GH
- KMID: 2534707
- Biomol Ther.
- 2022 Nov;30(6):570-575.
- doi: 10.4062/biomolther.2022.126
Stress breaks body balance, which can cause diverse physiological disorders and worsen preexisting diseases. However, recent studies have reported that controllable stress and overcoming from stress reinforce resilience to resist... -
- CITED
-
- Close
- SHARE
-
- Close
- p38 MAPK Inhibitor NJK14047 Suppresses CDNB-Induced Atopic Dermatitis-Like Symptoms in BALB/c Mice
-
Lee JH, Son SH, Kim NJ, Im DS
- KMID: 2534699
- Biomol Ther.
- 2022 Nov;30(6):501-509.
- doi: 10.4062/biomolther.2022.024
Atopic dermatitis (AD) is a chronic inflammatory skin disorder. Suppression of MAPKs and NF-κB is implicated as a vital mechanism of action of several traditional Chinese medicines for AD therapy.... -
- CITED
-
- Close
- SHARE
-
- Close
- Clinical Factors Affecting the Serum Retention of a Teratogenic Etretinate after the Acitretin Administration
-
Jeong JH, Hyun GH, Park YJ, Kwon SW, Lee AY
- KMID: 2534706
- Biomol Ther.
- 2022 Nov;30(6):562-569.
- doi: 10.4062/biomolther.2022.069
Etretinate, an acitretin metabolite, has a long retention duration in adipose tissues with a teratogenic potential. FDA advises a contraceptive period of at least three years after discontinuing acitretin. However,... -
- CITED
-
- Close
- SHARE
-
- Close
- HPV-18 E7 Interacts with Elk-1 Leading to Elevation of the Transcriptional Activity of Elk-1 in Cervical Cancer
-
Go SH, Rho SB, Yang DW, Kim BR, Lee CH, Lee SH
- KMID: 2534710
- Biomol Ther.
- 2022 Nov;30(6):593-602.
- doi: 10.4062/biomolther.2022.108
The human papillomavirus (HPV)-18 E7 (E7) oncoprotein is a major transforming protein that is thought to be involved in the development of cervical cancer. It is well-known that E7 stimulates... -
- CITED
-
- Close
- SHARE
-
- Close
- Immune Responses to Plant-Derived Recombinant Colorectal Cancer Glycoprotein EpCAM-FcK Fusion Protein in Mice
-
Lim CY, Kim DS, Kang Y, Lee YR, Kim K, Kim DS, Kim MS, Ko K
- KMID: 2534704
- Biomol Ther.
- 2022 Nov;30(6):546-552.
- doi: 10.4062/biomolther.2022.103
Epidermal cell adhesion molecule (EpCAM) is a tumor-associated antigen (TAA), which has been considered as a cancer vaccine candidate. The EpCAM protein fused to the fragment crystallizable region of immunoglobulin... -
- CITED
-
- Close
- SHARE
-
- Close
- Hydroxyzine Induces Cell Death in Triple-Negative Breast Cancer Cells via Mitochondrial Superoxide and Modulation of Jak2/STAT3 Signaling
-
Shakya R, Park GH, Joo SH, Shim JH, Choi JS
- KMID: 2534709
- Biomol Ther.
- 2022 Nov;30(6):585-592.
- doi: 10.4062/biomolther.2022.121
Treatment of triple-negative breast cancer (TNBC) has been limited due to the lack of molecular targets. In this study, we evaluated the cytotoxicity of hydroxyzine, a histamine H1 receptor antagonist... -
- CITED
-
- Close
- SHARE
-
- Close
- Growth Inhibitory and Pro-Apoptotic Effects of Hirsuteine in Chronic Myeloid Leukemia Cells through Targeting Sphingosine Kinase 1
-
Gao S, Guo T, Luo S, Zhang Y, Ren Z, Lang X, Hu G, Zuo D, Jia W, Kong D, Yu H, Qiu Y
- KMID: 2534705
- Biomol Ther.
- 2022 Nov;30(6):553-561.
- doi: 10.4062/biomolther.2022.023
Chronic myeloid leukemia (CML) is a slowly progressing hematopoietic cell disorder. Sphingosine kinase 1 (SPHK1) plays established roles in tumor initiation, progression, and chemotherapy resistance in a wide range of... -
- CITED
-
- Close
- SHARE
-
- Close
- A Novel Therapeutic Effect of a New Variant of CTLA4-Ig with Four Antennas That Are Terminally Capped with Sialic Acid in the CTLA4 Region
-
Piao Y, Yun SY, Kim HS, Park BK, Ha HC, Fu Z, Jang JM, Back MJ, Shin IC, Won JH, Kim DK
- KMID: 2534702
- Biomol Ther.
- 2022 Nov;30(6):529-539.
- doi: 10.4062/biomolther.2022.071
Rheumatoid arthritis (RA) is a multifactorial immune-mediated disease, the pathogenesis of which involves different cell types. T-cell activation plays an important role in RA. Therefore, inhibiting T-cell activation is one... -
- CITED
-
- Close
- SHARE
-
- Close
- AT9283, 1-Cyclopropyl-3-(3-(5-(Morpholinomethyl)-1H-Benzo[d] Imidazole-2-yl)-1H-Pyrazol-4-yl) Urea, Inhibits Syk to Suppress Mast Cell-Mediated Allergic Response
-
Kim SJ, Choi MY, Min KY, Jo MG, Kim JM, Kim HS, Kim YM
- KMID: 2534701
- Biomol Ther.
- 2022 Nov;30(6):520-528.
- doi: 10.4062/biomolther.2022.042
Mast cells are an effector cell that plays a pivotal role in type I hypersensitive immune responses. Mast cells exist in connective tissues, such as skin and mucosal tissue, and... -
- CITED
-
- Close
- SHARE
-
- Close
- Modulation of Autophagy is a Potential Strategy for Enhancing the Anti-Tumor Effect of Mebendazole in Glioblastoma Cells
-
Jo SB, Sung SJ, Choi HS, Park JS, Hong YK, Joe YA
- KMID: 2534712
- Biomol Ther.
- 2022 Nov;30(6):616-624.
- doi: 10.4062/biomolther.2022.122
Mebendazole (MBZ), a microtubule depolymerizing drug commonly used for the treatment of helminthic infections, has been suggested as a repositioning candidate for the treatment of brain tumors. However, the efficacy... -
- CITED
-
- Close
- SHARE
-
- Close
- Comparing Non-Communicable Disease Risk Factors in Asian Migrants and Native Koreans among the Asian Population
-
Piao H, Yun JM, Shin A, Cho B, Kang D
- KMID: 2534711
- Biomol Ther.
- 2022 Nov;30(6):603-615.
- doi: 10.4062/biomolther.2022.036
Assessing the health of international migrants is crucial in the Republic of Korea, Asia, and even worldwide. We compared the risk factors for non-communicable diseases among Asian migrants in Korea... -
- CITED
-
- Close
- SHARE
-
- Close
- Betulin, an Anti-Inflammatory Triterpenoid Compound, Regulates MUC5AC Mucin Gene Expression through NF-kB Signaling in Human Airway Epithelial Cells
-
Hossain R, Kim Ki, Jin F, Lee HJ, Lee CJ
- KMID: 2534703
- Biomol Ther.
- 2022 Nov;30(6):540-545.
- doi: 10.4062/biomolther.2022.093
Betulin is a triterpenoid natural product contained in several medicinal plants including Betulae Cortex. These medicinal plants have been used for controlling diverse inflammatory diseases in folk medicine and betulin... -
- CITED
-
- Close
- SHARE
-
- Close
