- Multifactorial Traits of SARS-CoV-2 Cell Entry Related to Diverse Host Proteases and Proteins
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You J, Seok JH, Joo M, Bae JY, Kim JI, Park MS, Kim K
- KMID: 2515269
- Biomol Ther.
- 2021 May;29(3):249-262.
- doi: 10.4062/biomolther.2021.048
The most effective way to control newly emerging infectious disease, such as the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, is to strengthen preventative or therapeutic public health strategies... -
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- Antiviral Efficacy of Pralatrexate against SARS-CoV-2
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Bae JY, Lee GE, Park H, Cho J, Kim J, Lee J, Kim K, Kim JI, Park MS
- KMID: 2515274
- Biomol Ther.
- 2021 May;29(3):268-272.
- doi: 10.4062/biomolther.2021.032
Novel coronavirus (SARS-CoV-2) has caused more than 100 million confirmed cases of human infectious disease (COVID-19) since December 2019 to paralyze our global community. However, only limited access has been... -
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- Suppression of Foxo3-Gatm by miR-132-3p Accelerates Cyst Formation by Up-Regulating ROS in Autosomal Dominant Polycystic Kidney Disease
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Choi S, Kim DY, Ahn Y, Lee EJ, Park JH
- KMID: 2515280
- Biomol Ther.
- 2021 May;29(3):311-320.
- doi: 10.4062/biomolther.2020.197
Accumulation of reactive oxygen species (ROS) is associated with the development of various diseases. However, the molecular mechanisms underlying oxidative stress that lead to such diseases like autosomal dominant polycystic... -
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- Differential Signaling and Virus Production in Calu-3 Cells and Vero Cells upon SARS-CoV-2 Infection
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Park BK, Kim D, Park S, Maharjan S, Kim J, Choi JK, Akauliya M, Lee Y, Kwon HJ
- KMID: 2515275
- Biomol Ther.
- 2021 May;29(3):273-281.
- doi: 10.4062/biomolther.2020.226
Severe acute respiratory syndrome CoV-2 (SARS-CoV-2) is responsible for the current coronavirus disease 2019 (COVID-19) pandemic. Signaling pathways that are essential for virus production have potential as therapeutic targets against... -
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- 3’-O-Acetyl-24-Epi-7,8-Didehydrocimigenol-3-O-β-DXylopryranoside Decreases Amyloid Beta Production in Amyloid Precursor Protein-Transfected HeLa Cells
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Lee SB, Park A, Ma CT, Kim YH, Yang HO
- KMID: 2515277
- Biomol Ther.
- 2021 May;29(3):290-294.
- doi: 10.4062/biomolther.2020.195
Extracellular beta amyloid (Aβ) plaques are the neuropathological hallmarks of Alzheimer’s disease (AD). Accordingly, reducing Aβ levels is considered a promising strategy for AD prevention. 3’-O-acetyl-24-epi-7,8-didehydrocimigenol-3-O-β-D-xylopryranoside significantly decreased the Aβ... -
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- Kaempferol Regulates the Expression of Airway MUC5AC Mucin Gene via IκBα-NF-κB p65 and p38-p44/42-Sp1 Signaling Pathways
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Li X, Jin F, Lee HJ, Lee CJ
- KMID: 2515279
- Biomol Ther.
- 2021 May;29(3):303-310.
- doi: 10.4062/biomolther.2020.149
In the present study, kaempferol, a flavonoidal natural compound found in Polygonati Rhizoma, was investigated for its potential effect on the gene expression and production of airway MUC5AC mucin. A... -
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- Recent Advances of Therapeutic Targets for the Treatment of Periodontal Disease
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Kim WJ, Soh Y, Heo SM
- KMID: 2515271
- Biomol Ther.
- 2021 May;29(3):263-267.
- doi: 10.4062/biomolther.2021.001
Periodontal disease is primarily associated with bacterial infection such as dental plaque. Dental plaque, an oral biofilm harboring a complex microbial community, can cause various inflammatory reactions in periodontal tissue.... -
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- SP-8356, a (1S)-(-)-Verbenone Derivative, Inhibits the Growth and Motility of Liver Cancer Cells by Regulating NF-κB and ERK Signaling
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Kim DH, Yong HJ, Mander S, Nguyen HT, Nguyen LP, Park HK, Cha HK, Kim WK, Hwang JI
- KMID: 2515282
- Biomol Ther.
- 2021 May;29(3):331-341.
- doi: 10.4062/biomolther.2020.200
Liver cancer is a common tumor and currently the second leading cause of cancer-related mortality globally. Liver cancer is highly related to inflammation as more than 90% of liver cancer... -
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- Inhibition of COX-2 Impairs Colon Cancer Liver Metastasis through Reduced Stromal Cell Reaction
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Herrero A, Benedicto A, Romayor I, Olaso E, Arteta B
- KMID: 2515283
- Biomol Ther.
- 2021 May;29(3):342-351.
- doi: 10.4062/biomolther.2020.160
Liver colonization is initiated through the interplay between tumor cells and adhesion molecules present in liver sinusoidal endothelial cells (LSECs). This crosstalk stimulates tumor COX-2 upregulation and PGE 2 secretion.... -
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- Papaverine Exerts Neuroprotective Effect by Inhibiting NLRP3 Inflammasome Activation in an MPTP-Induced Microglial Priming Mouse Model Challenged with LPS
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Leem YH, Park JS, Park JE, Kim DY, Kim HS
- KMID: 2515278
- Biomol Ther.
- 2021 May;29(3):295-302.
- doi: 10.4062/biomolther.2021.039
Microglial priming is the process of microglial proliferation and activation in response to neurodegeneration and abnormal protein accumulation. Priming makes microglia susceptible to secondary inflammatory stimuli and causes exaggerated inflammatory... -
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- Discovery of New Fusion Inhibitor Peptides against SARS-CoV-2 by Targeting the Spike S2 Subunit
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Kandeel M, Yamamoto M, Tani H, Kobayashi A, Gohda J, Kawaguchi Y, Park BK, Kwon HJ, Inoue Ji, Alkattan A
- KMID: 2515276
- Biomol Ther.
- 2021 May;29(3):282-289.
- doi: 10.4062/biomolther.2020.201
A novel coronavirus, severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), caused a worldwide pandemic. Our aim in this study is to produce new fusion inhibitors against SARS-CoV-2, which can be the... -
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- Protective Role of Transduced Tat-Thioredoxin1 (Trx1) against Oxidative Stress-Induced Neuronal Cell Death via ASK1-MAPK Signal Pathway
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Yeo EJ, Eum WS, Yeo HJ, Choi YJ, Sohn EJ, Kwon HJ, Kim DW, Kim DS, Cho SW, Park J, Han KH, Lee KW, Park JK, Shin MJ, Choi SY
- KMID: 2515281
- Biomol Ther.
- 2021 May;29(3):321-330.
- doi: 10.4062/biomolther.2020.154
Oxidative stress plays a crucial role in the development of neuronal disorders including brain ischemic injury. Thioredoxin 1 (Trx1), a 12 kDa oxidoreductase, has anti-oxidant and anti-apoptotic functions in various... -
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