- Cell Autonomous Circadian Systems and Their Relation to Inflammation
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Annamneedi VP, Park JW, Lee GS, Kang TJ
- KMID: 2510122
- Biomol Ther.
- 2021 Jan;29(1):31-40.
- doi: 10.4062/biomolther.2020.215
All living beings on earth have an important mechanism of 24-h periodicity, which controls their physiology, metabolism, and behavior. In humans, 24-h periodicity is regulated by the superchiasmatic nucleus (SCN)... -
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- Development of Free Fatty Acid Receptor 4 (FFA4/GPR120) Agonists in Health Science
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Son SE, Kim NJ, Im DS
- KMID: 2510121
- Biomol Ther.
- 2021 Jan;29(1):22-30.
- doi: 10.4062/biomolther.2020.213
Till the 21st century, fatty acids were considered as merely building blocks for triglycerides, phospholipids, or cholesteryl esters. However, the discovery of G protein-coupled receptors (GPCRs) for free fatty acids at... -
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- Suppressive Effect of Carnosol on Ovalbumin-Induced Allergic Asthma
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Lee JE, Im DS
- KMID: 2510125
- Biomol Ther.
- 2021 Jan;29(1):58-63.
- doi: 10.4062/biomolther.2020.050
Asthma is a chronic obstructive lung disease characterized by recurrent episodes of bronchoconstriction and wheezing. Conventional asthma treatment involves the suppression of airway inflammation or improving airway flow. Rosmarinus officialis,... -
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- The Role of Leptin in the Association between Obesity and Psoriasis
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Hwang J, Yoo JA, Yoon H, Han T, Yoon J, An S, Cho JY, Lee J
- KMID: 2510120
- Biomol Ther.
- 2021 Jan;29(1):11-21.
- doi: 10.4062/biomolther.2020.054
Adipose tissue secretes many adipokines which contribute to various metabolic processes, such as blood pressure, glucose homeostasis, inflammation and angiogenesis. The biology of adipose tissue in an obese individual is... -
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- SUV39H1 is a New Client Protein of Hsp90 Degradated by Chaetocin as a Novel C-Terminal Inhibitor of Hsp90
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Lian B, Lin Q, Tang W, Qi X, Li J
- KMID: 2510127
- Biomol Ther.
- 2021 Jan;29(1):73-82.
- doi: 10.4062/biomolther.2020.012
Hsp90 is often overexpressed with activated form in cancer cells, and many key cellular proteins are dependent upon the Hsp90 machinery (these proteins are called “client protein”). Nowadays, more client... -
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- Fumonisin B1-Induced Toxicity Was Not Exacerbated in Glutathione Peroxidase-1/Catalase Double Knock Out Mice
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Yayeh T, Jeong HR, Park YS, Moon S, Sur B, Yoo HS, Oh S
- KMID: 2510124
- Biomol Ther.
- 2021 Jan;29(1):52-57.
- doi: 10.4062/biomolther.2020.062
Fumonisin B1 (FB1) structurally resembles sphingolipids and interferes with their metabolism leading to sphingolipid dysregulation. We questioned if FB1 could exacerbate liver or kidney toxicities in glutathione peroxidase 1 (Gpx1)... -
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- COVID-19 Vaccine: Critical Questions with Complicated Answers
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Haidere MF, Ratan ZA, Nowroz S, Zaman SB, Jung YJ, Hosseinzadeh H, Cho JY
- KMID: 2510119
- Biomol Ther.
- 2021 Jan;29(1):1-10.
- doi: 10.4062/biomolther.2020.178
COVID-19 has caused extensive human casualties with significant economic impacts around the globe, and has imposed new challenges on health systems worldwide. Over the past decade, SARS, Ebola, and Zika... -
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- Thymoquinone Suppresses Migration of Human Renal Carcinoma Caki-1 Cells through Inhibition of the PGE 2 -Mediated Activation of the EP2 Receptor Pathway
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Park G, Song NY, Kim DH, Lee SJ, Chun KS
- KMID: 2510126
- Biomol Ther.
- 2021 Jan;29(1):64-72.
- doi: 10.4062/biomolther.2020.048
Renal cell carcinoma (RCC) is likely to metastasize to other organs, and is often resistant to conventional chemotherapies. Thymoquinone (TQ), a phytochemical derived from the seeds of Nigella sativa, has... -
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- Antaroide, a Novel Natural Nine-Membered Macrolide, Inhibits Melanin Biosynthesis in B16F10 Murine Melanoma Cells
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Ryu MJ, Baek EK, Kim S, Seong CN, Yang I, Lim KM, Nam SJ
- KMID: 2510130
- Biomol Ther.
- 2021 Jan;29(1):98-103.
- doi: 10.4062/biomolther.2020.064
Abstract The demand for natural substances with anti-melanogenic activity is increasing due to the recent interest in skin whitening. Intensive investigation on the culture broth of Streptomyces sp. SCO-736, a marine... -
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- Alpha-Synuclein Inclusion Formation in Human Oligodendrocytes
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Yoon YS, Ahn WJ, Ricarte D, Ortiz D, Shin CY, Lee SJ, Lee HJ
- KMID: 2510128
- Biomol Ther.
- 2021 Jan;29(1):83-89.
- doi: 10.4062/biomolther.2020.081
Multiple system atrophy (MSA) is a neurodegenerative disease characterized by presence of α-synuclein-positive inclusions in the cytoplasm of oligodendrocytes. These glial cytoplasmic inclusions (GCIs) are considered an integral part of... -
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- Phloroglucinol Attenuates Ultraviolet B-Induced 8-Oxoguanine Formation in Human HaCaT Keratinocytes through Akt and ErkMediated Nrf2/Ogg1 Signaling Pathways
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Piao MJ, Kim KC, Kang KA, Madushan Fernando PDS, Lakmini Herath HMU, Hyun JW
- KMID: 2510129
- Biomol Ther.
- 2021 Jan;29(1):90-97.
- doi: 10.4062/biomolther.2020.059
Ultraviolet B (UVB) radiation causes DNA base modifications. One of these changes leads to the generation of 8-oxoguanine (8-oxoG) due to oxidative stress. In human skin, this modification may induce... -
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- KF-1607, a Novel Pan Src Kinase Inhibitor, Attenuates Obstruction-Induced Tubulointerstitial Fibrosis in Mice
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Dorotea D, Lee S, Lee SJ, Lee G, Son JB, Choi HG, Ahn SM, Ha H
- KMID: 2510123
- Biomol Ther.
- 2021 Jan;29(1):41-51.
- doi: 10.4062/biomolther.2020.088
Src family kinases (SFKs), an important group of non-receptor tyrosine kinases, are suggested to be excessively activated during various types of tissue fibrosis. The present study investigated the effect of... -
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