- Towards the Application of Human Defensins as Antivirals
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Park MS, Kim JI, Lee I, Park S, Bae JY, Park MS
- KMID: 2421733
- Biomol Ther.
- 2018 May;26(3):242-254.
- doi: 10.4062/biomolther.2017.172
Defensins are antimicrobial peptides that participate in the innate immunity of hosts. Humans constitutively and/or inducibly express α- and β-defensins, which are known for their antiviral and antibacterial activities. This... -
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- Depolarizing Effectors of Bradykinin Signaling in Nociceptor Excitation in Pain Perception
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Choi SI, Hwang SW
- KMID: 2421734
- Biomol Ther.
- 2018 May;26(3):255-267.
- doi: 10.4062/biomolther.2017.127
Inflammation is one of the main causes of pathologic pain. Knowledge of the molecular links between inflammatory signals and pain-mediating neuronal signals is essential for understanding the mechanisms behind pain... -
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- Designing Tyrosinase siRNAs by Multiple Prediction Algorithms and Evaluation of Their Anti-Melanogenic Effects
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Kwon OS, Kwon SJ, Kim JS, Lee G, Maeng HJ, Lee J, Hwang GS, Cha HJ, Chun KH
- KMID: 2421737
- Biomol Ther.
- 2018 May;26(3):282-289.
- doi: 10.4062/biomolther.2017.115
Melanin is a pigment produced from tyrosine in melanocytes. Although melanin has a protective role against UVB radiation-induced damage, it is also associated with the development of melanoma and darker... -
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- Construction of a Transcriptome-Driven Network at the Early Stage of Infection with Influenza A H1N1 in Human Lung Alveolar Epithelial Cells
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Chung M, Cho SY, Lee YS
- KMID: 2421738
- Biomol Ther.
- 2018 May;26(3):290-297.
- doi: 10.4062/biomolther.2017.240
We aimed to understand the molecular changes in host cells that accompany infection by the seasonal influenza A H1N1 virus because the initial response rapidly changes owing to the fact... -
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- Effects and Mechanisms of Taurine as a Therapeutic Agent
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Schaffer S, Kim HW
- KMID: 2421732
- Biomol Ther.
- 2018 May;26(3):225-241.
- doi: 10.4062/biomolther.2017.251
Taurine is an abundant, β-amino acid with diverse cytoprotective activity. In some species, taurine is an essential nutrient but in man it is considered a semi-essential nutrient, although cells lacking... -
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- Cellular Prion Protein Enhances Drug Resistance of Colorectal Cancer Cells via Regulation of a Survival Signal Pathway
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Lee JH, Yun CW, Lee SH
- KMID: 2421741
- Biomol Ther.
- 2018 May;26(3):313-321.
- doi: 10.4062/biomolther.2017.033
Anti-cancer drug resistance is a major problem in colorectal cancer (CRC) research. Although several studies have revealed the mechanism of cancer drug resistance, molecular targets for chemotherapeutic combinations remain elusive.... -
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- The Effects of Donepezil, an Acetylcholinesterase Inhibitor, on Impaired Learning and Memory in Rodents
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Shin CY, Kim HS, Cha KH, Won DH, Lee JY, Jang SW, Sohn UD
- KMID: 2421736
- Biomol Ther.
- 2018 May;26(3):274-281.
- doi: 10.4062/biomolther.2017.189
A previous study in humans demonstrated the sustained inhibitory effects of donepezil on acetylcholinesterase (AChE) activity; however, the effective concentration of donepezil in humans and animals is unclear. This study... -
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- Administration of Alpha(s1)-Casein Hydrolysate Increases Sleep and Modulates GABA(A) Receptor Subunit Expression
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Yayeh T, Leem YH, Kim KM, Jung JC, Schwarz J, Oh KW, Oh S
- KMID: 2421735
- Biomol Ther.
- 2018 May;26(3):268-273.
- doi: 10.4062/biomolther.2017.083
Sleep is the most basic and essential physiological requirement for mental health, and sleep disorders pose potential risks of metabolic and neurodegenerative diseases. Tryptic hydrolysate of α(S1)-casein (α(S1)-CH) has been... -
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- Development of S-Methylmethionine Sulfonium Derivatives and Their Skin-Protective Effect against Ultraviolet Exposure
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Kim WS, Kim WK, Choi N, Suh W, Lee J, Kim DD, Kim I, Sung JH
- KMID: 2421740
- Biomol Ther.
- 2018 May;26(3):306-312.
- doi: 10.4062/biomolther.2017.109
In a previous study, we have demonstrated that S-methylmethionine sulfonium (SMMS) confers wound-healing and photoprotective effects on the skin, suggesting that SMMS can be used as a cosmetic raw material.... -
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- Panduratin A Inhibits Cell Proliferation by Inducing G0/G1 Phase Cell Cycle Arrest and Induces Apoptosis in Breast Cancer Cells
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Liu Q, Cao Y, Zhou P, Gui S, Wu X, Xia Y, Tu J
- KMID: 2421743
- Biomol Ther.
- 2018 May;26(3):328-334.
- doi: 10.4062/biomolther.2017.042
Because of the unsatisfactory treatment options for breast cancer (BC), there is a need to develop novel therapeutic approaches for this malignancy. One such strategy is chemotherapy using non-toxic dietary... -
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- Collagen-Induced Arthritis Analysis in Rhbdf2 Knockout Mouse
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Lee MY, Kang JS, Go RE, Byun YS, Wi YJ, Hwang KA, Choi JH, Kim HC, Choi KC, Nam KH
- KMID: 2421739
- Biomol Ther.
- 2018 May;26(3):298-305.
- doi: 10.4062/biomolther.2017.103
Rhomboid family member 2 gene (Rhbdf2) is an inactive homologue lacking essential catalytic residues of rhomboid intramembrane serine proteases. The protein is necessary for maturation of tumor necrosis factor-alpha (TNF-α)... -
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- Gomisin G Inhibits the Growth of Triple-Negative Breast Cancer Cells by Suppressing AKT Phosphorylation and Decreasing Cyclin D1
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Maharjan S, Park BK, Lee SI, Lim Y, Lee K, Kwon HJ
- KMID: 2421742
- Biomol Ther.
- 2018 May;26(3):322-327.
- doi: 10.4062/biomolther.2017.235
A type of breast cancer with a defect in three molecular markers such as the estrogen receptor, progesterone receptor, and human epidermal growth factor receptor is called triple-negative breast cancer... -
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