- Harnessing of Programmed Necrosis for Fighting against Cancers
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Cho YS, Park SY
- KMID: 2170633
- Biomol Ther.
- 2014 May;22(3):167-175.
Chemotherapy has long been considered as one of useful strategies for cancer treatment. It is primarily based on the apoptosis that can selectively kill cancer cells. However, cancer cells can... -
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- Enhancement of Platelet Aggregation by Ursolic Acid and Oleanolic Acid
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Kim M, Han CH, Lee MY
- KMID: 2170644
- Biomol Ther.
- 2014 May;22(3):254-259.
The pentacyclic triterpenoid ursolic acid (UA) and its isomer oleanolic acid (OA) are ubiquitous in food and plant medicine, and thus are easily exposed to the population through natural contact... -
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- Involvement of Transglutaminase-2 in alpha-MSH-Induced Melanogenesis in SK-MEL-2 Human Melanoma Cells
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Kim HJ, Lee HJ, Park MK, Gang KJ, Byun HJ, Park JH, Kim MK, Kim SY, Lee CH
- KMID: 2170638
- Biomol Ther.
- 2014 May;22(3):207-212.
Skin hyperpigmentation is one of the most common skin disorders caused by abnormal melanogenesis. The mechanism and key factors at play are not fully understood. Previous reports have indicated that... -
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- Luteolin Inhibits the Activity, Secretion and Gene Expression of MMP-3 in Cultured Articular Chondrocytes and Production of MMP-3 in the Rat Knee
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Kang BJ, Ryu J, Lee CJ, Hwang SC
- KMID: 2170642
- Biomol Ther.
- 2014 May;22(3):239-245.
We investigated whether luteolin affects the gene expression, secretion and activity of matrix metalloproteinase-3 (MMP-3) in primary cultured rabbit articular chondrocytes, as well as production of MMP-3 in the rat... -
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- Comparison of Piroxicam Pharmacokinetics and Anti-Inflammatory Effect in Rats after Intra-Articular and Intramuscular Administration
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Park CW, Ma KW, Jang SW, Son M, Kang MJ
- KMID: 2170645
- Biomol Ther.
- 2014 May;22(3):260-266.
This study evaluated the pharmacokinetic profile and therapeutic efficacy of piroxicam (PX), a long acting non-steroidal anti-inflammatory drug for the treatment of arthritis, following intra-articular (IA) injection in comparison to... -
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- Amelioration of Cognitive Dysfunction in APP/PS1 Double Transgenic Mice by Long-Term Treatment of 4-O-Methylhonokiol
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Jung YY, Lee YJ, Choi DY, Hong JT
- KMID: 2170641
- Biomol Ther.
- 2014 May;22(3):232-238.
Alzheimer's disease (AD) is the most common neurodegenerative disease without known ways to cure. A key neuropathologic manifestation of the disease is extracellular deposition of beta-amyloid peptide (Abeta). Specific mechanisms... -
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- Neuroprotective Effect of Steamed and Fermented Codonopsis lanceolata
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Weon JB, Yun BR, Lee J, Eom MR, Ko HJ, Lee HY, Park DS, Chung HC, Chung JY, Ma CJ
- KMID: 2170643
- Biomol Ther.
- 2014 May;22(3):246-253.
Codonopsis lanceolata has been used as an herbal medicine for several lung infl ammatory diseases, such as asthma, tonsillitis, and pharyngitis. Previously, we showed the neuroprotective effect of steamed and... -
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- N-(p-Coumaryol)-Tryptamine Suppresses the Activation of JNK/c-Jun Signaling Pathway in LPS-Challenged RAW264.7 Cells
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Vo VA, Lee JW, Park JH, Kwon JH, Lee HJ, Kim SS, Kwon YS, Chun W
- KMID: 2170637
- Biomol Ther.
- 2014 May;22(3):200-206.
N-(p-Coumaryol) tryptamine (CT), a phenolic amide, has been reported to exhibit anti-oxidant and anti-inflammatory activities. However, the underlying mechanism by which CT exerts its pharmacological properties has not been clearly... -
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- L-Tetrahydropalmatine Ameliorates Development of Anxiety and Depression-Related Symptoms Induced by Single Prolonged Stress in Rats
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Lee B, Sur B, Yeom M, Shim I, Lee H, Hahm DH
- KMID: 2170639
- Biomol Ther.
- 2014 May;22(3):213-222.
Abnormal adaptation of the stress-response system following traumatic stress can lead to alterations in the hypothalamic-pituitary-adrenal (HPA) axis that may contribute to the development of post-traumatic stress disorder (PTSD). The... -
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- Houttuynia cordata Improves Cognitive Deficits in Cholinergic Dysfunction Alzheimer's Disease-Like Models
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Huh E, Kim HG, Park H, Kang MS, Lee B, Oh MS
- KMID: 2170634
- Biomol Ther.
- 2014 May;22(3):176-183.
Cognitive impairment is a result of dementia of diverse causes, such as cholinergic dysfunction and Alzheimer's disease (AD). Houttuynia cordata Thunb. (Saururaceae) has long been used as a traditional herbal... -
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- Britanin Suppresses IgE/Ag-Induced Mast Cell Activation by Inhibiting the Syk Pathway
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Lu Y, Li X, Park YN, Kwon O, Piao D, Chang YC, Kim CH, Lee E, Son JK, Chang HW
- KMID: 2170636
- Biomol Ther.
- 2014 May;22(3):193-199.
The aim of this study was to determine whether britanin, isolated from the flowers of Inula japonica (Inulae Flos), modulates the generation of allergic inflammatory mediators in activated mast cells.... -
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- Cordycepin-Enriched WIB801C from Cordyceps militaris Inhibits Collagen-Induced [Ca2+]i Mobilization via cAMP-Dependent Phosphorylation of Inositol 1, 4, 5-Trisphosphate Receptor in Human Platelets
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Lee DH, Kim HH, Cho HJ, Yu YB, Kang HC, Kim JL, Lee JJ, Park HJ
- KMID: 2170640
- Biomol Ther.
- 2014 May;22(3):223-231.
In this study, we prepared cordycepin-enriched (CE)-WIB801C, a n-butanol extract of Cordyceps militaris-hypha, and investigated the effect of CE-WIB801C on collagen-induced human platelet aggregation. CE-WIB801C dose-dependently inhibited collagen-induced platelet aggregation,... -
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- beta-lapachone-Induced Apoptosis of Human Gastric Carcinoma AGS Cells Is Caspase-Dependent and Regulated by the PI3K/Akt Pathway
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Yu HY, Kim SO, Jin CY, Kim GY, Kim WJ, Yoo YH, Choi YH
- KMID: 2170635
- Biomol Ther.
- 2014 May;22(3):184-192.
beta-lapachone is a naturally occurring quinone that selectively induces apoptotic cell death in a variety of human cancer cells in vitro and in vivo; however, its mechanism of action needs... -
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