- Intercellular Lipid Mediators and GPCR Drug Discovery
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Im DS
- KMID: 2170658
- Biomol Ther.
- 2013 Nov;21(6):411-422.
G-protein-coupled receptors (GPCR) are the largest superfamily of receptors responsible for signaling between cells and tissues, and because they play important physiological roles in homeostasis, they are major drug targets.... -
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- Nucleic Acid Aptamers: New Methods for Selection, Stabilization, and Application in Biomedical Science
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Kong HY, Byun J
- KMID: 2170659
- Biomol Ther.
- 2013 Nov;21(6):423-434.
The adoption of oligonucleotide aptamer is well on the rise, serving an ever increasing demand for versatility in biomedical field. Through the SELEX (Systematic Evolution of Ligands by EXponential enrichment),... -
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- Impact of High Fat Diet-induced Obesity on the Plasma Levels of Monoamine Neurotransmitters in C57BL/6 Mice
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Kim M, Bae S, Lim KM
- KMID: 2170666
- Biomol Ther.
- 2013 Nov;21(6):476-480.
Obesity is one of the most serious health problems in developed countries. It negatively affects diverse aspects of human wellbeing. Of these, a relationship between obesity and depression is widely... -
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- Cell Motility Is Decreased in Macrophages Activated by Cancer Cell-Conditioned Medium
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Go A, Ryu YK, Lee JW, Moon EY
- KMID: 2170667
- Biomol Ther.
- 2013 Nov;21(6):481-486.
Macrophages play a role in innate immune responses to various foreign antigens. Many products from primary tumors influence the activation and transmigration of macrophages. Here, we investigated a migration of... -
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- The Longevity Properties of 1,2,3,4,6-Penta-O-Galloyl-beta-D-Glucose from Curcuma longa in Caenorhabditis elegans
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Ahn D, Cha DS, Lee EB, Kim BJ, Lee SY, Jeon H, Ahn MS, Lim HW, Lee HY, Kim DK
- KMID: 2170661
- Biomol Ther.
- 2013 Nov;21(6):442-446.
Here in this study, we isolated 1,2,3,4,6-penta-O-galloyl-beta-D-glucose (PGG) from Curcuma longa L. and elucidated the lifespanextending effect of PGG using Caenorhabditis elegans model system. In the present study, PGG demonstrated... -
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- A ROCK Inhibitor Blocks the Inhibitory Effect of Chondroitin Sulfate Proteoglycan on Morphological Changes of Mesenchymal Stromal/Stem Cells into Neuron-Like Cells
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Lim HS, Joe YA
- KMID: 2170662
- Biomol Ther.
- 2013 Nov;21(6):447-453.
Chondroitin sulfate proteoglycan (CSPG) inhibits neurite outgrowth of various neuronal cell types, and CSPG-associated inhibition of neurite outgrowth is mediated by the Rho/ROCK pathway. Mesenchymal stromal/stem cells (MSCs) have the... -
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- Inhibitory Effects of Eucommia ulmoides Oliv. Bark on Scopolamine-Induced Learning and Memory Deficits in Mice
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Kwon SH, Ma SX, Joo HJ, Lee SY, Jang CG
- KMID: 2170664
- Biomol Ther.
- 2013 Nov;21(6):462-469.
Eucommia ulmoides Oliv. Bark (EUE) is commonly used for the treatment of hypertension, rheumatoid arthritis, lumbago, and ischialgia as well as to promote longevity. In this study, we tested the... -
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- Evaluation of Luminescent P450 Analysis for Directed Evolution of Human CYP4A11
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Choi S, Han S, Lee H, Chun YJ, Kim D
- KMID: 2170668
- Biomol Ther.
- 2013 Nov;21(6):487-492.
Cytochrome P450 4A11 (CYP4A11) is a fatty acid hydroxylase enzyme expressed in human liver. It catalyzes not only the hydroxylation of saturated and unsaturated fatty acids, but the conversion of... -
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- Emodin Isolated from Polygoni cuspidati Radix Inhibits TNF-alpha and IL-6 Release by Blockading NF-kappaB and MAP Kinase Pathways in Mast Cells Stimulated with PMA Plus A23187
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Lu Y, Jeong YT, Li X, Kim MJ, Park PH, Hwang SL, Son JK, Chang HW
- KMID: 2170660
- Biomol Ther.
- 2013 Nov;21(6):435-441.
Emodin, a naturally occurring anthraquinone derivative isolated from Polygoni cuspidati radix, has several beneficial pharmacologic effects, which include anti-cancer, anti-diabetic, and anti-inflammatory activities. In this study, the authors examined the... -
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- Neuroprotective Effects of a Butanol Fraction of Rosa hybrida Petals in a Middle Cerebral Artery Occlusion Model
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Yang G, Park D, Lee SH, Bae DK, Yang YH, Kyung J, Kim D, Choi EK, Hong JT, Jeong HS, Kim HJ, Jang SK, Joo SS, Kim YB
- KMID: 2170663
- Biomol Ther.
- 2013 Nov;21(6):454-461.
The neuroprotective effects of a butanol fraction of white rose petal extract (WRPE-BF) were investigated in a middle cerebral artery occlusion (MCAO) model. Seven week-old male rats were orally administered... -
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- Direct Analysis in Real Time Mass Spectrometry (DART-MS) Analysis of Skin Metabolome Changes in the Ultraviolet B-Induced Mice
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Park HM, Kim HJ, Jang YP, Kim SY
- KMID: 2170665
- Biomol Ther.
- 2013 Nov;21(6):470-475.
Ultraviolet (UV) radiation is a major environmental factor that leads to acute and chronic reactions in the human skin. UV exposure induces wrinkle formation, DNA damage, and generation of reactive... -
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