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Effectiveness of premedication and rapid desensitization in hypersensitivity to L-asparaginase

Yoon DH, Kang SH, Kim HS, Lee JW, Yoon JS, Chung NG, Cho B

PURPOSE: L-asparaginase is a crucial chemotherapeutic agent for the treatment of acute lymphoblastic leukemia. However, hypersensitivity to L-asparaginase is common which limits its clinical use. METHODS: We performed 44 cases of...
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A Clinical Study of the Side Effects of L-Asparaginase

Woo CW, Lee JH, Lee KC, Kim SK

  • KMID: 2278186
  • Korean J Pediatr Hematol Oncol.
  • 1999 Oct;6(2):298-304.
PURPOSE: We evaluated the frequency and clinical characteristics of the side effects of L-asparaginase during treatment of childrens with acute lymphoblastic leukemia (ALL) & Non-Hodgkin lymphoma (NHL). METHODS: Medical records...
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A Case of Cerebral Infarction in a Child with Acute Lymphoblastic Leukemia Developed during Chemotherapy with E coli Asparaginase

Oh JH, Cho HS, Han SW, Park CY

  • KMID: 2037445
  • Korean J Pediatr Hematol Oncol.
  • 2000 Oct;7(2):305-309.
E. coli L-asparaginase treatment during induction therapy in acute lymphoblastic leukemia is known to be rarely complicated by thromboembolic events. It causes deficiencies of antithrombin III, plasminogen, fibrinogen, factor...
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Comparison of Native Escherichia coli L-Asparaginase versus Pegylated Asparaginase, in Combination with Ifosfamide, Methotrexate, Etoposide, and Prednisolone, in Extranodal NK/T-Cell Lymphoma, Nasal Type

Kim HJ, Ock CY, Kim TM, Lee SH, Lee JY, Jung SH, Cho YS, Kim M, Keam B, Kim DW, Kim IH, Heo DS

PURPOSE: The aim of this study was to compare asparaginase-related toxicities in two asparaginase preparations, namely native Escherichia coli L-asparaginase (L-ASP) and pegylated asparaginase (PEG-ASP) in combination with ifosfamide, methotrexate,...
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Analysis of L-asparaginase Related Adverse Reaction

Ko KM, La HO

OBJECTIVE: L-asparaginase (L-ASP) is a critical agent for the treatment of acute lymphoblastic leukemia and lymphoma, which is associated with serious toxicities including hypersensitivity, pancreatitis and thrombosis. METHODS: To evaluate the...
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A Case of Oligodendroglioma after Treatment of Acute Lymphoblastic Leukemia in Childhood

Shin SH, Chung BH, Bauer S, Lee JH, Lee KC

  • KMID: 2049282
  • Clin Pediatr Hematol Oncol.
  • 2012 Oct;19(2):118-122.
Secondary brain tumors after cranial irradiation have been reported in survivors of childhood acute lymphoblastic leukemia (ALL). We report a case of secondary oligodendroglioma, occurring in a 19-year-old male, 12...
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Treatment Outcome of Adult Acute Lymphocytic Leukemia with VPD (L) Regimen: analysis of Prognostic Factors

Park SR, Kim JH, Kim DY, Lee SH, Lee SY, Choi IS, Yoon SS, Park SY, Kim BG, Kim NK

  • KMID: 759630
  • Korean J Intern Med.
  • 2003 Mar;18(1):21-28.
BACKGROUND: Because of the relative paucity of data regarding the clinical outcome in adult patients with acute lymphocytic leukemia (ALL) in Korea, we analyzed clinical courses in adult ALL patients...
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