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Metabolomics strategies to discover new biomarkers associated to severe allergic phenotypes

Barber D, Villaseñor A, Escribese

In the last decades have emerged new technological platforms that allow evaluation of genes, transcripts, proteins, or metabolites of a living being, so-called omics sciences. More importantly, new technics for...
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New ERS cough guidelines: A clinical framework for refining the patient management strategy

Song WJ, Millqvist , Morice AH

No abstract available.
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Continued loss of asthma control following epidemic thunderstorm asthma

Foo CT, Yee EL, Young A, Denton E, Hew M, O'Hehir RE, Radhakrishna N, Matthews S, Conron M, Harun NS, Lachapelle P, Douglass J, Irving L, Lee J, Stevenson , McDonald C, Langton D, Banks C, Thien F

BACKGROUND: Epidemic thunderstorm asthma (ETSA) severely affected Melbourne, Australia in November 2016. There is scant literature on the natural history of individuals affected by ETSA. OBJECTIVE: A multicentre 12-month prospective observational...
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Goat's milk anaphylaxis in a cow's milk tolerant child

Goh SH, Chong KW, Loh W, Goh AE

Goat's milk (GM) allergy commonly occurs together with cow's milk (CM) allergy due to cross-reactivity between highly homologous proteins. We present an unusual case of GM anaphylaxis in a CM...
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The risk of preschool asthma at 2–4 years is not associated with leukocyte telomere length at birth or at 1 year of age

Suh DI, Kang MJ, Park YM, Lee JK, Lee SY, Sheen YH, Kim KW, Ahn K, Hong SJ

BACKGROUND: Exposure to prenatal stress is associated with offspring allergic-disease development, and oxidative stress may mediate this relationship. OBJECTIVE: We aimed to evaluate whether leukocyte telomere length (LTL) shortening, a marker...
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Respiratory syncytial virus increases eosinophil extracellular traps in a murine model of asthma

Silveira J, Antunes GL, Gassen RB, Breda RV, Stein RT, Pitrez PM, da Cunha A

BACKGROUND: Respiratory viral infections are the leading cause of asthma exacerbations. Eosinophil activation results in the formation of eosinophil extracellular traps (EETs), which release web-like structures of DNA and proteins...
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Cough related to swallowing in asthma patients

Kamimura M, Mouri A, Takayama K, Mizutani T, Hamamoto Y, Iikura M, Furihata K

BACKGROUND: Occurrence of cough during swallowing is common among asthma patients, but has not been investigated in detail. OBJECTIVE: We conducted an observational study to determine the prevalence of swallowing-related cough...
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IgE-mediated allergy to proton pump inhibitors with both delayed and immediate onset

Barakat L, Vasconcelos MJ, Bourrain J, Demoly P, Chiriac AM

Proton pump inhibitors (PPIs) are widely used for the treatment of gastrointestinal diseases. Incidence of drug hypersensitivity reactions (DHRs) to PPIs has been rising, presumably because of their increased consumption....
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Chlorhexidine: a hidden life-threatening allergen

Fernandes , Lourenço , Lopes A, Spínola Santos A, Pereira Santos MC, Pereira Barbosa M

Chlorhexidine is a commonly used antiseptic and disinfectant in the health-care setting. Anaphylaxis to chlorhexidine is a rare but potentially life-threatening complication. Epidemiologic data suggest that the cases of chlorhexidine...
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