- SNP genetic polymorphisms of MDR-1, CYP1A2 and CYPB11 genes in four canine breeds upon toxicological evaluation
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Gagliardi , Llambi S, Arruga MV
- KMID: 2344299
- J Vet Sci.
- 2015 Sep;16(3):273-280.
- doi: 10.4142/jvs.2015.16.3.273
The fields of pharmacogenetics and pharmacogenomics have become increasingly promising regarding the clinical application of genetic data to aid in prevention of adverse reactions. Specific screening tests can predict which... -
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- A Case of Intolerance to Warfarin Dosing in an Intermediate Metabolizer of CYP2C9
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Lee SY, Kim JS, Kim JW
- KMID: 2428302
- Yonsei Med J.
- 2005 Dec;46(6):843-846.
We report a case of intolerance to warfarin dosing due to impaired drug metabolism in a patient heterozygous for the CYP2C9*3 allele. A 30-year-old woman with an artificial cardiac pacemaker... -
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- Cytochrome P450 2C19 Polymorphism is Associated with Reduced Clopidogrel Response in Cerebrovascular Disease
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Lee JB, Lee KA, Lee KY
- KMID: 1108064
- Yonsei Med J.
- 2011 Sep;52(5):734-738.
- doi: 10.3349/ymj.2011.52.5.734
PURPOSE: Clopidogrel is a prodrug that requires transformation into an active metabolite by cytochrome P450 (CYP) in the liver in order to irreversibly inhibit the P2Y12 adenosine diphosphate platelet receptor.... -
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