- NRAMP1 gene polymorphisms in patients with rheumatoid arthritis in Koreans
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Yang YS, Kim SJ, Kim JW, Koh EM
- KMID: 1731240
- J Korean Med Sci.
- 2000 Feb;15(1):83-87.
- doi: 10.3346/jkms.2000.15.1.83
Natural resistance-associated macrophage protein 1 (Nramp1) is a genetic locus associated with innate resistance or susceptibility of murine hosts to infection with intracellular pathogens such as Salmonella, Leishmania and Mycobacterium.... -
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- Expression of p53 protein in rheumatoid arthritis synovium. An immunohistochemical analysis
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Lee YH, Ji JD, Kim A, Kim CH, Song GG
- KMID: 759085
- Korean J Intern Med.
- 1999 Jan;14(1):59-65.
OBJECTIVES: Mutation of p53 may play a role in manifestation of rheumatoid arthritis synovium, but several studies on p53 expression in synovial tissues of rheumatoid arthritis showed conflicting... -
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- Role of Endoplasmic Reticulum Stress in Rheumatoid Arthritis Pathogenesis
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Park YJ, Yoo SA, Kim WU
- KMID: 1796908
- J Korean Med Sci.
- 2014 Jan;29(1):2-11.
- doi: 10.3346/jkms.2014.29.1.2
Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by abnormal proliferation of synoviocytes, leukocyte infiltration, and angiogenesis. The endoplasmic reticulum (ER) is the site of biosynthesis for all secreted... -
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- Induction of Macrophage Migration Inhibitory Factor in ConA-Stimulated Rheumatoid Arthritis Synovial Fibroblasts through the P38 MAP Kinase-Dependent Signaling Pathway
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Kim HR, Park MK, Cho ML, Kim KW, Oh HJ, Park JS, Heo YM, Lee SH, Kim HY, Park SH
- KMID: 1776614
- Korean J Intern Med.
- 2010 Sep;25(3):317-326.
- doi: 10.3904/kjim.2010.25.3.317
BACKGROUND/AIMS: This study was undertaken to identify the intracellular signaling pathway involved in induction of macrophage migration inhibitory factor (MIF) in human rheumatoid arthritis (RA) synovial fibroblasts. METHODS: Human RA... -
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- Slug suppression induces apoptosis via Puma transactivation in rheumatoid arthritis fibroblast-like synoviocytes treated with hydrogen peroxide
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Cha HS, Bae EK, Ahn JK, Lee J, Ahn KS, Koh EM
- KMID: 1078358
- Exp Mol Med.
- 2010 Jun;42(6):428-436.
- doi: 10.3858/emm.2010.42.6.044
Inadequate apoptosis contributes to synovial hyperplasia in rheumatoid arthritis (RA). Recent study shows that low expression of Puma might be partially responsible for the decreased apoptosis of fibroblast-like synoviocytes (FLS).... -
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- Crosstalk between FLS and chondrocytes is regulated by HIF-2alpha-mediated cytokines in arthritis
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Huh YH, Lee G, Song WH, Koh JT, Ryu JH
- KMID: 2359884
- Exp Mol Med.
- 2015 Dec;47(12):e197.
- doi: 10.1038/emm.2015.88
Rheumatoid arthritis (RA) and osteoarthritis (OA), two common types of arthritis, affect the joints mainly by targeting the synovium and cartilage. Increasing evidence indicates that a significant network connects synovitis... -
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- Regulation of B cell activating factor (BAFF) receptor expression by NF-kappaB signaling in rheumatoid arthritis B cells
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Woo YJ, Yoon BY, Jhun JY, Oh HJ, Min S, Cho ML, Park SH, Kim HY, Min JK
- KMID: 1107376
- Exp Mol Med.
- 2011 Jun;43(6):350-357.
- doi: 10.3858/emm.2011.43.6.038
B cells play an important role in the pathogenesis of rheumatoid arthritis (RA). High levels of B cell activating factor (BAFF) are detected in autoimmune diseases. BAFF and BAFF receptor... -
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- Meta-Analysis of Genetic Association Studies
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Lee YH
- KMID: 2363199
- Ann Lab Med.
- 2015 May;35(3):283-287.
- doi: 10.3343/alm.2015.35.3.283
The object of this review is to help readers to understand meta-analysis of genetic association study. Genetic association studies are a powerful approach to identify susceptibility genes for common diseases.... -
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