- Tanshinone IIA, an ingredient of Salvia miltiorrhiza BUNGE, induces apoptosis in human leukemia cell lines through the activation of caspase-3
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Sung HJ, Choi SM, Yoon YS, An KS
- KMID: 1029923
- Exp Mol Med.
- 1999 Dec;31(4):174-178.
Tanshinone II-A is a derivative of phenanthrene-quinone isolated from Salvia miltiorrhiza BUNGE, a traditional herbal medicine that is known to induce antiinflammatory, anti-oxidative and cytotoxic activity. We have... -
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- Dose-dependent effect of resveratrol on proliferation and apoptosis in endothelial and tumor cell cultures
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Szende B, Tyihak E, Kiraly-Veghely Z
- KMID: 1109308
- Exp Mol Med.
- 2000 Jun;32(2):88-92.
Experimental data suggest that Resveratrol, a compound found in grapes and other fruits may influence cell proliferation and apoptosis. The aim of our experiments was to study the effect of... -
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- The role of Bcl-xL and nuclear factor-kappaB in the effect of taxol on the viability of dendritic cells
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Kim MH, Joo HG
- KMID: 1102965
- J Vet Sci.
- 2009 Jun;10(2):99-103.
- doi: 10.4142/jvs.2009.10.2.99
Taxol has been used effectively in cancer therapies. Our previous study demonstrated that taxol induced altered maturation and improved viability of dendritic cells (DCs). However, the effects of taxol on... -
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- The Levels of MDM2 Protein Are Decreased by a Proteasome-Mediated Proteolysis Prior to Caspase-3-Dependent pRb and PARP Cleavages
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Cho JW, Park JC, Lee JC, Kwon TK, Park JW, Baek WK, Suh SI, Suh MH
- KMID: 648246
- J Korean Med Sci.
- 2001 Apr;16(2):135-139.
- doi: 10.3346/jkms.2001.16.2.135
MDM2 is a substrate of caspase-3 in p53-mediated apoptosis. In addition, MDM2 mediates its own ubiquitination in a RING finger-dependent manner. Thus, we investigated whether MDM2 is degraded through a... -
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- 5-Formylhonokiol exerts anti-angiogenesis activity via inactivating the ERK signaling pathway
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Zhu W, Fu A, Hu J, Wang T, Luo Y, Peng M, Ma Y, Wei Y, Chen L
- KMID: 1109403
- Exp Mol Med.
- 2011 Mar;43(3):146-152.
- doi: 10.3858/emm.2011.43.3.017
Our previous report has demonstrated that 5-formylhonokiol (FH), a derivative of honokiol (HK), exerts more potent anti-proliferative activities than honokiol in several tumor cell lines. In present study, we first... -
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- Nuclear factor E2-related factor 2 Dependent Overexpression of Sulfiredoxin and Peroxiredoxin III in Human Lung Cancer
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Kim YS, Lee HL, Lee KB, Park JH, Chung WY, Lee KS, Sheen SS, Park KJ, Hwang SC
- KMID: 1022170
- Korean J Intern Med.
- 2011 Sep;26(3):304-313.
- doi: 10.3904/kjim.2011.26.3.304
BACKGROUND/AIMS: Oxidative stress results in protein oxidation and is implicated in carcinogenesis. Sulfiredoxin (Srx) is responsible for the enzymatic reversal of inactivated peroxiredoxin (Prx). Nuclear factor E2-related factor 2 (Nrf2)... -
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