- Detection of SV40 Large T Antigen in Malignant Lymphomas
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Kim YA, Chang M, Paik J, Yoon SO, Jeon YK, Kim CW, Kim JE
- KMID: 2459589
- Korean J Pathol.
- 2009 Aug;43(4):312-316.
BACKGROUND: The association of simian virus 40 (SV40) with certain types of human cancers, including malignant lymphomas, has been a topic of interest for some time. Although the virus is... -
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- U6 is unsuitable for normalization of serum miRNA levels in patients with sepsis or liver fibrosis
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Benz F, Roderburg , Vargas Cardenas D, Vucur M, Gautheron , Koch A, Zimmermann H, Janssen J, Nieuwenhuijsen L, Luedde M, Frey N, Tacke F, Trautwein , Luedde T
- KMID: 2154261
- Exp Mol Med.
- 2013 Sep;45(9):e42.
MicroRNA (miRNA) levels in serum have recently emerged as potential novel biomarkers for various diseases. miRNAs are routinely measured by standard quantitative real-time PCR (qPCR); however, the high sensitivity of... -
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- Immortalization of human embryonic fibroblasts by overexpression of c-myc and simian virus 40 large T antigen
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Kim HS, Shin JY, Yun JY, Ahn DK, Lee JY
- KMID: 1457544
- Exp Mol Med.
- 2001 Dec;33(4):293-298.
SV40 large T antigen, a viral oncoprotein, is known to immortalize human diploid fibroblast by soaking up cellular RB and p53, but its frequency is extremely low. Additional genetic alteration... -
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- Dedifferentiation of conditionally immortalized hepatocytes with long-term in vitro passage
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Kim BH, Sung SR, Choi EH, Kim YI, Kim KJ, Dong SH, Kim HJ, Chang YW, Lee JI, Chang R
- KMID: 927131
- Exp Mol Med.
- 2000 Mar;32(1):29-37.
The rat hepatocytes were immortalized using a temperature-sensitive mutant of SV40 large T antigen (tsT) to develop as a possible substitute for primary hepatocytes. Four rat hepatocyte lines that have... -
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- Characterization of a brain tumor cell line established from transgenic mice expressing the vasopressin SV-40 T antigen
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Kim SH, Kim MO, Lee SR, Kim KS, Lee TH, Lee HT, Ha JH, Kim TY, Ryoo ZY
- KMID: 1094144
- Exp Mol Med.
- 2006 Jun;38(3):196-202.
We previously reported that transgenic mice produced with a transgene consisting of the SV40 T antigen and vasopressin without the 3'-flanking region exhibit brain tumors and lymphoma. In this study,... -
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