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Bioavailability of the amino acid-attached prodrug as a new anti-HIV agent in rats

Chae KA, Cho HJ, Sung JM, Lee H, Seo DC, Kim JS, Shin HC

The primary objective of this study was to compare thepharmacokinetics of a new anti-human immunodeficiencyvirus agent 1-(2-amino-pyridin-4-ylmethyl)-6-(3,5-dimethyl-benzoyl)-5-isopropyl-1H-pyrimidine-2,4-dione (VP-0502)with its amino acid prodrug alanine amide of VP-0502(VP-0502AL), following intravenous and oral...
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