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Angiotensin II Modulates p130Cas of Podocytes by the Suppression of AMP-Activated Protein Kinase

Ha TS, Park HY, Seong SB, Ahn HY

Angiotensin II (Ang II) induces the pathological process of vascular structures, including renal glomeruli by hemodynamic and nonhemodynamic direct effects. In kidneys, Ang II plays an important role in the...
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Inhibitory effect of Hsp70 on angiotensin II-induced vascular smooth muscle cell hypertrophy

Zheng Y, Im CN, Seo JS

  • KMID: 1098085
  • Exp Mol Med.
  • 2006 Oct;38(5):509-518.
Angiotensin II (Ang II), which is an important mediator of both vascular responsiveness and growth, has been shown to induce vascular smooth muscle cell (VSMC) hypertrophy via the activation of...
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Inhibitory Effect of Angiotensin II Receptor Antagonist on the Contraction and Growth of Hepatic Stellate Cells

Baik SK, Jo HS, Suk KT, Kim JM, Lee BJ, Choi YJ, Kim HS, Lee DK, Kwon SO, Lee KI, Cha SK, Park KS, Kong ID

  • KMID: 772535
  • Korean J Gastroenterol.
  • 2003 Aug;42(2):134-141.
BACKGROUNDS/AIMS: This study aimed to investigate the effects of angiotensin II (ANG II) and its receptor antagonist (losartan) on the contraction and growth of HSCs. METHODS: HSCs were isolated...
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Effects of High Glucose on Interleukin-6 Production in Human Mesangial Cells

Ihm CG, Park JK, Kim HJ, Lee TW, Cha DR

Interleukin (IL)-6 is an autocrine growth factor for mesangial cells. It is not known whether high glucose influences IL-6 production in mesangial cells. Angiotensin II (AGII) is involved in the...
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Catechins inhibit angiotensin II-induced vascular smooth muscle cell proliferation via mitogen-activated protein kinase pathway

Won SM, Park YH, Kim HJ, Park KM, Lee WJ

  • KMID: 1098087
  • Exp Mol Med.
  • 2006 Oct;38(5):525-534.
Catechins, components of green tea, reduce the incidence of cardiovascular diseases such as atherosclerosis. Angiotensin II (Ang II) is highly implicated in the proliferation of vascular smooth muscle cells (VSMC),...
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Orphan nuclear receptor small heterodimer partner inhibits angiotensin II-stimulated PAI-1 expression in vascular smooth muscle cells

Lee KM, Seo HY, Kim MK, Min AK, Ryu SY, Kim YN, Park YJ, Choi HS, Lee KU, Park WJ, Park KG, Lee IK

Angiotensin II is a major effector molecule in the development of cardiovascular disease. In vascular smooth muscle cells (VSMCs), angiotensin II promotes cellular proliferation and extracellular matrix accumulation through the...
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The effects of high glucose concentration on angiotensin II- or transforming growth factor-beta-induced DNA synthesis, hypertrophy and collagen synthesis in cultured rat mesangial cells

Choi KH, Kang SW, Lee HY, Han DS

Hyperglycemia is a principal characteristic of diabetes, and has an influence on many cellular functions. In order to investigate whether the intracellular signaling pathways inducing proliferation, hypertrophy and matrix synthesis...
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