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Transition nuclear protein 1 as a novel biomarker in patients with fertilization failure

Mirsanei JS, Gholipour H, Zandieh Z, Jahromi MG, Masroor MJ, Mehdizadeh M, Amjadi F

Objective: Although intracytoplasmic sperm injection (ICSI) is a way to deal with in vitro fertilization failure, 3% of couples still experience repeated fertilization failure after attempted ICSI, despite having sperm...
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Metabolomic profiling of embryo culture media in patients with repeated implantation failure during assisted reproductive technology cycles

Nami S, Govahi A, Najjar N, Ghasemi S, Rezaei F, Amjadi F, Taheripak G

Objective: This study investigated the metabolic status of the spent culture media from embryos of patients with repeated implantation failure (RIF) undergoing in vitro fertilization–intracytoplasmic sperm injection cycles in comparison...
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Variable localization of Toll-like receptors in human fallopian tube epithelial cells

Amjadi F, Zandieh Z, Salehi E, Jafari R, Ghasemi N, Aflatoonian A, Fazeli A, Aflatoonian R

OBJECTIVE: To determine the localization, expression, and function of Toll-like receptors (TLRs) in fallopian tube epithelial cells. METHODS: The localization of TLRs in fallopian tube epithelial cells was investigated by immunostaining....
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Evaluation of polyglycolic acid as an animal-free biomaterial for three-dimensional culture of human endometrial cells

Amiri S, Bagher Z, Sene AA, Aflatoonian R, Mehdizadeh M, Milan PB, Ghazizadeh L, Ashrafi M, Amjadi F

Objective: Animal-free scaffolds have emerged as a potential foundation for consistent, chemically defined, and low-cost materials. Because of its good potential for high biocompatibility with reproductive tissues and well-characterized scaffold...
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TLR-1, TLR-2, and TLR-6 MYD88–dependent signaling pathway: A potential factor in the interaction of high-DNA fragmentation human sperm with fallopian tube epithelial cells

Zandieh Z, Govahi A, Aghamajidi A, Raoufi E, Amjadi F, Aghajanpour S, Golestan M, Aflatoonian R

Objective: The DNA integrity of spermatozoa that attach to fallopian tube (FT) cells is higher than spermatozoa that do not attach. FT epithelial cells can distinguish normal and abnormal sperm...
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Sex hormones alter the response of Toll-like receptor 3 to its specific ligand in fallopian tube epithelial cells

Zandieh Z, Amjadi F, Vakilian H, Aflatoonian K, Amirchaghmaghi E, Fazeli A, Aflatoonian R

OBJECTIVE: The fallopian tubes play a critical role in the early events of fertilization. The rapid innate immune defense is an important part of the fallopian tubes. Toll-like receptor 3...
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