- Klotho and the Aging Process
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Kuro-o M
- KMID: 1776581
- Korean J Intern Med.
- 2011 Jun;26(2):113-122.
- doi: 10.3904/kjim.2011.26.2.113
The klotho gene was originally identified as a putative age-suppressing gene in mice that extends life span when overexpressed. It induces complex phenotypes resembling human premature aging syndromes when disrupted.... -
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- The renin-angiotensin system and aging in the kidney
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Yoon HE, Choi BS
- KMID: 1792052
- Korean J Intern Med.
- 2014 May;29(3):291-295.
- doi: 10.3904/kjim.2014.29.3.291
Aging is associated with progressive functional deterioration and structural changes in the kidney. Changes in the activity or responsiveness of the renin-angiotensin system (RAS) occur with aging. RAS changes predispose... -
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- Snapshot of degenerative aging of porcine intervertebral disc: a model to unravel the molecular mechanisms
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Cho H, Park SH, Lee S, Kang M, Hasty KA, Kim SJ
- KMID: 1107374
- Exp Mol Med.
- 2011 Jun;43(6):334-340.
- doi: 10.3858/emm.2011.43.6.036
Larger animal models, such as porcine, have been validated as appropriate models of the human disc with respect to biomechanics and biochemistry. They are advantageous for research as the models... -
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