Korean J Intern Med.  2014 May;29(3):291-295. 10.3904/kjim.2014.29.3.291.

The renin-angiotensin system and aging in the kidney

• Yoon HE
• Choi BS

• KMID: 1792052
• DOI: http://doi.org/10.3904/kjim.2014.29.3.291

Abstract

Aging is associated with progressive functional deterioration and structural changes in the kidney. Changes in the activity or responsiveness of the renin-angiotensin system (RAS) occur with aging. RAS changes predispose the elderly to various fluid and electrolyte imbalances as well as acute kidney injury and chronic kidney disease. Among the multiple pathways involved in renal aging, the RAS plays a central role. This review summarizes the association of the RAS with structural and functional changes in the aging kidney and age-related renal injury, and describes the underlying mechanisms of RAS-related renal aging. An improved understanding of the renal aging process may lead to better individualized care of the elderly and improved renal survival in age-related diseases.

Keyword

Aging; Kidney; Renin-angiotensin system

MeSH Terms

Acute Kidney Injury/etiology/metabolism/physiopathology
Age Factors
Aging/genetics/*metabolism
Animals
Glucuronidase/genetics/metabolism
Humans
Kidney/*metabolism/physiopathology
Kidney Diseases/*etiology/genetics/metabolism/physiopathology
Prognosis
*Renin-Angiotensin System
Risk Factors
Glucuronidase