- MDL-12330A potentiates TRAIL-induced apoptosis in gastric cancer cells through CHOP-mediated DR5 upregulation
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Lim SC, Han SI
- KMID: 2384453
- Korean J Physiol Pharmacol.
- 2017 Jul;21(4):397-405.
- doi: 10.4196/kjpp.2017.21.4.397
MDL-12330A is a widely used adenylyl cyclase (AC) inhibitor that blocks AC/cAMP signaling. In this study, we demonstrated a novel antitumor activity of this drug in gastric carcinoma (GC) cell... -
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- Action Mechanisms of Hormone Binding to Cell Surface Receptors: 1) G-protein Coupled Receptor Signalling as Targets for Hormone Action: (1) Adenylate Cyclase Cascade
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Baik JH
- KMID: 2199638
- J Korean Soc Endocrinol.
- 2000 Jun;15(3):311-332.
No Abstract Available. -
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- Simultaneous measurement of thyroid growth stimulating antibody and thyroid adenylate cyclase stimulating antibody using FRTL-5 cells in patients with Graves' disease
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Shong YK, Moon DH, Lee KU, Lee MH, Lee M, Cho BY, Koh CS
- KMID: 2199333
- J Korean Soc Endocrinol.
- 1991 Mar;6(1):17-24.
No abstract available. -
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- Studies on the Specific Estradiol Binding Site on Rat Uterine Membranes
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Yoon MC, Ryu KZ
- KMID: 2461661
- J Korean Soc Endocrinol.
- 1996 Dec;11(4):510-516.
Backgroand: In our previous study, it was demonstrated that estradiol-dependent prostaglandin synthesis may be mediated by cAMP elevation during the process of iplantation in rats. The present study was undertaken... -
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- Altered Renal Expression of Aquaporin-2 Water Channels in Two-Kidney, One Clip Hypertension in Rats
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Lee SY
- KMID: 2172442
- Chonnam Med J.
- 2000 Dec;36(4):337-342.
The present study was aimed at examining the regulation of aquaporin-2 (AQP2) water channels in the kidney in two-kidney, one clip (2K1C) hypertension. Rats were made 2K1C hypertensive for 6... -
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- Effects of Schisandra chinensis fruit extract and gomisin A on the contractility of penile corpus cavernosum smooth muscle: a potential mechanism through the nitric oxide - cyclic guanosine monophosphate pathway
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Choi BR, Kim HK, Park JK
- KMID: 2420994
- Nutr Res Pract.
- 2018 Aug;12(4):291-297.
- doi: 10.4162/nrp.2018.12.4.291
BACKGROUND/OBJECTIVES: This study evaluated the effects and molecular mechanisms of the Schisandra chinensis fruit extract (SC) and its major compound gomisin A (GA), on the contractility of rabbit penile corpus... -
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- An Experimental Study about the Effects of Parathyroid Hormone on Osteoblasts
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Suh SW, Lee SH, Chang JS, Kim MK
- KMID: 2423587
- J Korean Orthop Assoc.
- 1996 Feb;31(1):140-153.
- doi: 10.4055/jkoa.1996.31.1.140
Authors concluded an experimental study in order to find out what the effects of parathyroid hormone on cells derived from human Trabecular bone in vitro are on terms of proliferation... -
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- Fatty Acid Increases cAMP-dependent Lactate and MAO-B-dependent GABA Production in Mouse Astrocytes by Activating a G(αs) Protein-coupled Receptor
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Lee N, Sa M, Hong YR, Lee CJ, Koo J
- KMID: 2424731
- Exp Neurobiol.
- 2018 Oct;27(5):365-376.
- doi: 10.5607/en.2018.27.5.365
Medium-chain fatty acids (MCFAs) are mostly generated from dietary triglycerides and can penetrate the blood-brain barrier. Astrocytes in the brain use MCFAs as an alternative energy source. In addition, MCFAs... -
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- Decreased Expression of Aquaporin-2 Water Channels in the Kidney in Rats Treated with Chlorpropamide
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Kim SW, Lee JU, Li YS, Oh YW, Kim NH, Choi KC
- KMID: 2254431
- Korean J Nephrol.
- 2002 May;21(3):375-381.
BACKGROUND: Whether blood glucose levels may change the regulation of aquaporin(AQP) water channels in the kidney was investigated. METHODS: Male Sprague-Dawley rats were treated with chlorpropamide(40 mg/100 g body weight... -
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- The Affinity of Calmodulin-Affigel for Inositol Triphosphate Kinase From Bovine Brain
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Lim SW, Kim JH
- KMID: 2377305
- Yeungnam Univ J Med.
- 1990 Jun;7(1):39-50.
- doi: 10.12701/yujm.1990.7.1.39
The one event on signaling mechanism is the cleavage by adenyl cyclase of ATP into second messenger, cyclic AMP. The other transfer system of inositol metabolism, it is widely recognized... -
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- Regulation of adenosine receptors in rat brain following chronic carbamazepine treatment
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Park KS, Yang WS, Kim KH
- KMID: 2285153
- Korean J Physiol Pharmacol.
- 1997 Feb;1(1):13-17.
Carbamazepine (CBZ), an anticonvulsant, has been reported to displace ligands at adenosine receptors. Several studies have demonstrated that as far as A-2 adenosine receptors is concerned, CBZ acts as an antagonist. However, the... -
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- Analysis of a Sphingosine 1-phosphate Receptor hS1P3 in Rat Hepatoma Cells
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Im DS
- KMID: 2285242
- Korean J Physiol Pharmacol.
- 2002 Jun;6(3):139-142.
To examine intracellular signaling of human S1P3 (hS1P3), a sphingosine 1-phosphate (S1P) receptor in plasma membrane, hS1P3 DNA was transfected into RH7777 rat hepatoma cell line, and the inhibition of... -
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- Role of Protein Kinase in Spontaneous Phasic Contraction of Cat Gastric Smooth Muscle
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Sim SS, Choi JC, Kim MS, Kim CJ, Jo YH
- KMID: 2240381
- Korean J Gastroenterol.
- 2000 Mar;35(3):283-290.
Gastric muscle contraction is known to be regulated by complicated mechanism. In the present study, the role of protein kinase in the modulation of spontaneous gastric phasic contraction was investigated. METHODS: Circular muscle... -
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- Functional Characterization of cAMP-Regulated Gene, CAR1, in Cryptococcus neoformans
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Jung KW, Maeng S, Bahn YS
- KMID: 2312560
- Mycobiology.
- 2010 Mar;38(1):26-32.
The cyclic AMP (cAMP) pathway plays a major role in growth, sexual differentiation, and virulence factor synthesis of pathogenic fungi. In Cryptococcus neoformans, perturbation of the cAMP pathway, such as... -
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- Altered Regulation of Water Channels and Sodium Transporters in Fasting-induced Polyuria in Rat Kidney
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Park BS, Bae EH, Kang WH, Park JW, Ma SK, Kim NH, Choi KC, Lee JU, Kim SW
- KMID: 2254126
- Korean J Nephrol.
- 2007 Jan;26(1):14-22.
PURPOSE: Starvation causes impairment in the urinary concentration ability. However, the molecular basis for the impaired urinary concentration and polyuria remains undefined. We examined the effects of food deprivation on... -
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- Increases of cAMP Production and Urinary cAMP Excretion by Oxytocin in the Inner Medullary Collecting Duct(IMCD)
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Na KY, Jeon US, Joo KW, Huh WS, Lee JG, Jung WK, Kim KS, Kim YS, Ahn C, Han JS, Kim SG, Lee JS
- KMID: 2254583
- Korean J Nephrol.
- 2000 Jan;19(1):58-63.
Oxytocin, like vasopressin, has been known to act in the IMCD by the activation of adenylyl cyclase through V2 receptor, but the exact mechanism of its action remains to be... -
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- Ultraviolet Light-Induced Relaxant Response in Arterial Smooth Muscles, Mediators of the Response and Effect of Calcium Modulators on the Relaxation
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Baik YH, Kim JK, Kim YI, Lee J, Kang JC
- KMID: 2228995
- Korean Circ J.
- 1991 Dec;21(6):1126-1136.
- doi: 10.4070/kcj.1991.21.6.1126
Effects of Ultratiolet (UV) light was studied in isolated thoracic aortae of rabbits and porcine coronary arteries. The following results were obtained. 1) Radiation of UV light did not affect... -
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- P2 Receptor-mediated Inhibition of Vasopressin-stimulated Fluid Transport and cAMP Responses in AQP2-transfected MDCK Cells
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Kim YH, Choi YJ, Bae HR, Woo JS
- KMID: 2285365
- Korean J Physiol Pharmacol.
- 2009 Feb;13(1):9-14.
- doi: 10.4196/kjpp.2009.13.1.9
We cultured canine kidney (MDCK) cells stably expressing aquaporin-2 (AQP2) on collagen-coated permeable membrane filters and examined the effect of extracellular ATP on arginine vasopressin (AVP)-stimulated fluid transport and cAMP... -
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- Reversal of an Unconditioned Behavioral Preference for Specific Food Pellets by Intervention of Whisker Sensory Inputs
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Kim H, Lee Y, Kim JE, Han PL
- KMID: 2352877
- Exp Neurobiol.
- 2016 Apr;25(2):79-85.
- doi: 10.5607/en.2016.25.2.79
Adenylyl cyclase type-5 (AC5) is preferentially expressed in the dorsal striatum. Recently, we reported that AC5 knockout (KO) mice preferred food pellets carrying an olfactory cue produced by AC5 KO... -
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- Effect of Somatostatin on Cholecystokinin-Induced Amylase Release in Rat Pancreatic Acini
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Rhie DJ, Choi WS, Yi SY, Yoon SH, Hahn SJ, Sim SS, Kim MS, Jo YH
- KMID: 2304683
- Korean J Gastroenterol.
- 1998 Dec;32(6):773-781.
BACKGROUND/AIMS: The inhibitory effect of somatostatin (SS) on cholecystokinin (CCK)-induced amylase release and the role of intracellular cAMP in this process were investigated. METHODS: Pancreatic acini were isolated from rat pancreas... -
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