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Peritoneal dissemination of high-grade serous ovarian cancer: pivotal roles of chromosomal instability and epigenetic dynamics

Konishi I, Abiko K, Hayashi T, Yamanoi K, Murakami R, Yamaguchi K, Hamanishi J, Baba T, Matsumura N, Mandai M, Kyoto Study Group for Ovarian Cancer Research

Epithelial ovarian cancer remains the lethal gynecological malignancy in women. The representative histotype is high-grade serous carcinoma (HGSC), and most patients with HGSC present at advanced stages with peritoneal dissemination....
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Unenhanced region on magnetic resonance imaging represents tumor progression in uterine carcinosarcoma

Inoue A, Yamaguchi , Kurata Y, Murakami R, Abiko K, Hamanishi , Kondoh E, Baba T, Kido A, Konishi I, Matsumura

OBJECTIVE: Carcinosarcoma of the uterine corpus has a poor prognosis. Although pathological necrosis is a prognostic factor of endometrial cancer, the clinicopathological influences of an unenhanced region observed on magnetic...
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The efficacy of secondary cytoreductive surgery for recurrent ovarian, tubal, or peritoneal cancer in Tian-model low-risk patients

So M, Miyamoto T, Murakami R, Abiko K, Hamanishi , Baba T, Mandai M

OBJECTIVE: In patients with recurrent ovarian cancer (ROC) in whom surgery is likely to render them disease-free, it is unclear whether secondary cytoreductive surgery (SCS) combined with chemotherapy is superior...
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Serum lactate dehydrogenase is a possible predictor of platinum resistance in ovarian cancer

Ikeda A, Yamaguchi K, Yamakage H, Abiko K, Satoh-Asahara N, Takakura K, Konishi I

Objective The need for tailoring ovarian cancer treatments to individual patients is increasing. This study aimed to evaluate the prognostic value of pretreatment laboratory test data for predicting the response...
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Groin lymph node detection and sentinel lymph node biopsy in vulvar cancer

Sakae C, Yamaguchi , Matsumura , Nakai H, Yoshioka Y, Kondoh E, Hamanishi , Abiko K, Koshiyama , Baba T, Kido A, Mandai M, Konishi I

OBJECTIVE: To identify suitable diagnostic tools and evaluate the efficacy of sentinel lymph node (SLN) biopsy for inguinal lymph node metastasis in vulvar cancer. METHODS: Data from 41 patients with vulvar...
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Adult granulosa cell tumors of the ovary: a retrospective study of 30 cases with respect to the expression of steroid synthesis enzymes

Kitamura S, Abiko K, Matsumura , Nakai H, Akimoto Y, Tanimoto H, Konishi I

OBJECTIVE: Some, but not all, granulosa cell tumors are characterized by estrogen production. This study was designed to determine whether there are clinical or pathological variations in granulosa cell tumors...
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