- Is CD137 Ligand (CD137L) Signaling a Fine Tuner of Immune Responses?
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Kwon B
- KMID: 2168037
- Immune Netw.
- 2015 Jun;15(3):121-124.
- doi: 10.4110/in.2015.15.3.121
Now, it has been being accepted that reverse signaling through CD137 ligand (CD137L) plays an important role in vivo during hematopoiesis and in immune regulation. However, due to technical difficulty... -
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- CD137-CD137 Ligand Interactions in Inflammation
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Kwon B
- KMID: 2150646
- Immune Netw.
- 2009 Jun;9(3):84-89.
- doi: 10.4110/in.2009.9.3.84
The main stream of CD137 studies has been directed to the function of CD137 in CD8+ T-cell immunity, including its anti-tumor activity, and paradoxically the immunosuppressive activity of CD137, which... -
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- 4-1BB (CD137) signals depend upon CD28 signals in alloimmune responses
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Lee EA, Kim JE, Seo JH, Kwon BS, Nam SH, Kwon B, Cho HR
- KMID: 1115938
- Exp Mol Med.
- 2006 Dec;38(6):606-615.
Our previous study has demonstrated that there is a significant delay of Balb/c cardiac allograft rejection in the C57BL/6 4-1BB-deficient knockout recipient. In this study, we examined the effect of... -
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- Expression of 4-1BB and 4-1BBL in thymocytes during thymus regeneration
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Kim YM, Kim HK, Kim HJ, Lee HW, Ju SA, Choi BK, Kwon BS, Kim BS, Kim JB, Lim YT, Yoon S
- KMID: 1099866
- Exp Mol Med.
- 2009 Dec;41(12):896-911.
- doi: 10.3858/emm.2009.41.12.095
4-1BB, a member of the tumor necrosis factor receptor (TNFR) superfamily, is a major costimulatory receptor that is rapidly expressed on the surface of CD4+ and CD8+ T cells after... -
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- Ex vivo Expansion of Human Natural Killer Cells from Blood Retained in a Disposable Platelet Apheresis Set
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Shin DJ, Cho D, Jang YY, Park JY, Kim JS, Kim SK, Lee JJ, Jang MJ, Shin MG, Ryang DW
- KMID: 1440719
- Korean J Blood Transfus.
- 2012 Apr;23(1):28-37.
BACKGROUND: Natural killer cells expanded from human peripheral blood (PB) have been used in cancer immunotherapy research. Although most research teams have access to human PB, it is necessary to... -
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- Recombinant TAT-CD137 Ligand Cytoplasmic Domain Fusion Protein Induces the Production of IL-6 and TNF-alpha in Peritoneal Macrophages
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Kim JD, Lee EA, Quang NN, Cho HR, Kwon B
- KMID: 1449813
- Immune Netw.
- 2011 Aug;11(4):216-222.
- doi: 10.4110/in.2011.11.4.216
BACKGROUND: The ligand for CD137 (CD137L; also called 4-1BBL) is mainly expressed on activated APCs such as dendritic cells, B cells and macrophages. Even though CD137L functions as a trigger... -
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