- Studies on the Cytotoxicity and Antineoplastic Activity of Methyl Gallate
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Han DS, Lee SR, Jung WY
- KMID: 1558427
- Korean J Anat.
- 2001 Apr;34(2):131-139.
In order to develop antitumor agent which indicates weak side effects and strong antitumor activity, cytotoxicity and antitumor effects of MG was evaluated by MTT assay and SRB assay of... -
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- The optimal conditions to improve retrovirus-mediated transduction efficiency to NIH 3T3 cells
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Lee JA, Lee KM, Lee HJ, Lee YJ, Kim DH, Lim JS, Park KD
- KMID: 2279316
- Korean J Pediatr.
- 2007 Oct;50(10):1011-1017.
- doi: 10.3345/kjp.2007.50.10.1011
PURPOSE: We tried to assess the optimal conditions to improve low transduction efficiency and their effect on target cells. METHODS: Cultured NIH 3T3 cells were incubated with retroviral vectors bearing an... -
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- The effect of Insulin like growth factor-I (IGF-I) and IGF binding protein-3 (IGFBP-3) on cellular proliferation in mouse 3T3 fibroblast cells
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Cho CH, Kwak SM, Moon TH, Cho JH, Ryu JS, Lee HL
- KMID: 2318244
- Tuberc Respir Dis.
- 1999 Nov;47(5):618-628.
BACKGROUND: Cell growth is a balance between cell proliferation and cell death. Insulin-like growth factor-I(IGF-I), which binds IGF-I receptor (IGF-IR), mediates cellular proliferation as a potent mitogen. IGF binding protein-3... -
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- Candida spp.- Induced Cytokine Gene Expression on Mouse Peritoneal Macrophages and NIH 3T3 Fibroblasts
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Kim HS, Kim SK, Lee YS, Kim SD
- KMID: 1551638
- J Korean Soc Microbiol.
- 1998 Jun;33(3):237-245.
Interaction with Candida albicans (C. albicans) causes secretion of a variety of cytokines by macrophages. Although macrophages and neutrophils are thought to be major effector cell types in inflammation, fibroblasts... -
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- Effect of short-term ethanol on the proliferative response of Swiss 3T3 cells to mitogenic growth factors
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Yeo EJ, Lim HK, Park SC
- KMID: 755081
- Exp Mol Med.
- 2000 Sep;32(3):161-169.
Both adaptive and deleterious responses of cells to ethanol are likely triggered by short-term interactions of the cells with ethanol. Many studies have demonstrated the direct effect of ethanol... -
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- Antisense GLUT1 RNA suppresses the transforming phenotypes of NIH 3T3 cells transformed by N-Ras
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Choi JW, Yoon DJ, Lee HW, Han DP, Ahn YH
- KMID: 699859
- Yonsei Med J.
- 1995 Dec;36(6):480-486.
- doi: 10.3349/ymj.1995.36.6.480
An antisense approach was attempted to investigate the role of antisense GLUT1 RNA in suppressing tumor cell phenotypes using N-ras-transformed NIH 3T3 cells. The established cell line transformed by ras... -
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- Changes in the expression of c-myc, RB and tyrosine-phosphorylated proteins during proliferation of NIH 3T3 cells induced by hyaluronic acid
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Moon SO, Lee JH, Kim TJ
- KMID: 754984
- Exp Mol Med.
- 1998 Mar;30(1):29-33.
We have shown that hyaluronic acid stimulates the proliferation of quiescent NIH 3T3 cells. We have shown that treatment of 1 mg/ml hyaluronic acid results in increase of tyrosine phosphorylation of two... -
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- The Difference in Biological Properties between Parental and v-Ha-ras Transformed NIH3T3 Cells
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Lee M, Ahn JH, Eum KH
- KMID: 2165985
- Cancer Res Treat.
- 2009 Jun;41(2):93-99.
PURPOSE: We performed experiments to investigate the change in cellular signaling that occurs during the transformation of a normal cell to a cell capable of cancerous growth, and we did... -
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- Effects of Nocodazole on Protein Synthesis Appratus of Tumor Cells
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Kim SH, Kim JY, Sung EG, Lee YC
- KMID: 1529461
- Korean J Anat.
- 1997 Jun;30(3):243-258.
Nocodazole is an anticancer agent that acts on microtubules or filaments. HeLa, Hep G2, A549, L929 and NIH/3T3 cell lines were cultivated in alpha-MEM with 3micrometer or 30micrometer nocodazole. To... -
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- Tissue engineering of dental pulp on type I collagen
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Lee GH, Huh SY, Park SH
- KMID: 2175631
- J Korean Acad Conserv Dent.
- 2004 Jul;29(4):370-377.
- doi: 10.5395/JKACD.2004.29.4.370
The purpose of this study was to regenerate human dental pulp tissues similar to native pulp tissues. Using the mixture of type I collagen solution, primary cells collected from the... -
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- The role of Rho GTPases in the regulation of the rearrangement of actin cytoskeleton and cell movement
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Begum R, Nur-E-Kamal MSA, Zaman MA
- KMID: 1094080
- Exp Mol Med.
- 2004 Aug;36(4):358-366.
The rearrangement of the actin cytoskeleton has been shown to play a critical role in the development of transformation and malignant phenotype of cancer cells. Rho family GTPases regulate the... -
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- Retinoic acid inhibits inducible nitric oxide synthase expression in 3T3-L1 adipocytes
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Yang JY, Koo BS, Kang MK, Rho HW, Sohn HS, Jhee EC, Park JW
- KMID: 755207
- Exp Mol Med.
- 2002 Nov;34(5):353-360.
The present study was undertaken to explore whether retinoids, which are known to have immunomodulatory actions, could attenuate tumor necrosis factor-alpha (TNF)-stimulated inducible nitric oxide synthase (iNOS) expression in 3T3-L1... -
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- Efficient Cultivation Conditions for Human Limbal Epithelial Cells
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Kim MK, Lee JL, Oh JY, Shin MS, Shin KS, Wee WR, Lee JH, Park KS, Son YS
- KMID: 1783074
- J Korean Med Sci.
- 2008 Oct;23(5):864-869.
- doi: 10.3346/jkms.2008.23.5.864
To compare the stem niche in different culture conditions of limbal epithelial cells, the suspended human limbal epithelial cells (HLECs) were seeded on the 3T3-pretreated plates and the other suspended... -
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- Effects of Gangliosides on DNA Synthesis in U1242 MG Glioma Cells
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Cho KH, Lee MC
- KMID: 2065998
- J Korean Neurol Assoc.
- 1995 Dec;13(4):749-761.
Exogenously added gangliosides modulate the growth and differentiation of a variety of cells in vitro including human gliomas. GM1, Gdla and GTlb gangliosides inhibit both PDGF-stimulated and serum-stimulated DNA synthesis... -
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- Role of Pertussis Toxin-sensitive G Protein-coupled Receptor Signaling in the Proliferation of Bone Marrow Mesenchymal Stem Cells
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Kim SW, Hwang JH, Jin SA, Yun GW, Yang YJ, Park NW, Lee HJ, Yun HJ, Jo DY, Kim S
- KMID: 2252265
- Korean J Hematol.
- 2007 Mar;42(1):24-32.
- doi: 10.5045/kjh.2007.42.1.24
BACKGROUND: Bone marrow (BM) mesenchymal stem cells (MSCs) can be expanded over 20~30 cell doublings in vitro even in the absence of any growth factors. However, the mechanisms that govern... -
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- Role of Shc and phosphoinositide 3-kinase in heregulin-induced mitogenic signaling via ErbB3
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Kim MS, Koland JG
- KMID: 1581029
- Korean J Physiol Pharmacol.
- 2000 Dec;4(6):507-513.
ErbB3/HER3 is a cell surface receptor which belongs to the ErbB/HER subfamily of receptor protein tyrosine kinases. When expressed in NIH/3T3 cells, ErbB3 can form heterodimeric coreceptor with endogenous ErbB2. Among known intracellular... -
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- Effects of cyclosporin A on sex hormone and estrogen receptor in male rat with special reference to cyclosporin A-induced osteoporosis
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Shin WY, Li SZ, Chung SS, Lee HC, Huh KB, Lim SK
- KMID: 1060273
- Yonsei Med J.
- 2000 Feb;41(1):61-67.
- doi: 10.3349/ymj.2000.41.1.61
The mechanisms of high turnover bone loss induced by Cyclosporin A (CsA) are not clearly understood. Deficiencies in sex hormones result in high turnover osteoporosis, and not only androgen but... -
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- Role of protease inhibitors and acylation stimulating protein in the adipogenesis in 3T3-L1 cells
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Soliman MM, El-Senosi , Salem MM, Hamid OM, Kazuhiro K
- KMID: 1726918
- J Vet Sci.
- 2009 Sep;10(3):197-201.
- doi: 10.4142/jvs.2009.10.3.197
Treatment of AIDS (HIV) and hepatitis C virus needs protease inhibitors (PI) to prevent viral replication. Uses of PI in therapy are usually associated with a decrease in body weight... -
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- The Effect of GTP Cyclohydrolase I on the Activity and Expression of Tyrosine Hydroxylase and Cell Growth
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Lee YJ, Han IS, Yi SD
- KMID: 2342761
- J Korean Neurol Assoc.
- 1999 Jan;17(1):122-130.
BACKGROUND: Parkinson's Disease (PD) is a progressive neurodegenerative disorder characterized by resting tremor, rigidity, and bradykinesia. L-3,4-dihydroxyphenylalanine (L-dopa) has been used for over last 3 decades to treat this disorder,... -
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- The regulatory mechanism of phosphatidylinositol 3-kinase by insulin in 3T3 L1 fibroblasts: phosphorylation-independent activation of phosphatidylinositol 3-kinase
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Kang IS, Choi SL, Kim SS, Kim SJ, Ha JH, Oh SM, Kim SS
- KMID: 755019
- Exp Mol Med.
- 1998 Dec;30(4):263-269.
Phosphatidylinositol (PI) 3-kinase plays an important role in transducing the signals of various growth factor receptors. However, the regulatory mechanism of PI3-kinase activity by these growth factor receptors is not... -
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