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Altered Regulation of 11beta-hydroxysteroid Dehydrogenase II in the Kidney of Rats with Experimental Hypertension

Kang SS, Kim SW, Lee JU

The present study was aimed at investigating the role of type II 11beta-hydroxysteroid dehydrogenase (IIbeta- HSD II) in the development of hypertension. Two-kidney, one-clip (2K1C), deoxycorticosterone acetate (DOCA)/salt, or NG-nitro-L-arginine...
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Licorice Induced Hypokalemia

Cho S, Lim B, Cho H, Joung J, Choi Y, Kim D, Shin G, Kim H

  • KMID: 2079205
  • Korean J Nephrol.
  • 2001 Nov;20(6):1021-1025.
A high intake of licorice can cause hypermineralocorticoidism with sodium retention and potassium loss, edema, increased blood pressure and depression of renin-angiotensin-aldosterone system. Glycyrrhizic acid, a component of licorice, produces...
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Mitochondrial Dysfunction in Adipocytes as a Primary Cause of Adipose Tissue Inflammation

Woo CY, Jang JE, Lee SE, Koh EH, Lee KU

Adipose tissue inflammation is considered a major contributing factor in the development of obesity-associated insulin resistance and cardiovascular diseases. However, the cause of adipose tissue inflammation is presently unclear. The...
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A Case of Licorice-Induced Hypokalemic Rhabdomyolysis in a Patient Using a Diuretic Drug

Park KA, Seok SJ, Kim SJ, Gil HW, Yang JO, Lee EY, Hong SY

  • KMID: 2258900
  • Korean J Med.
  • 2011 Jun;80(Suppl 2):S258-S262.
Glycyrrhizic acid is a component of licorice. It can cause hypokalemia through the inhibition of 11beta-hydroxysteroid dehydrogenase. The severity of symptoms depends on the dose and duration of licorice intake,...
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Dysregulation of ENaC in Animal Models of Nephrotic Syndrome and Liver Cirrhosis

Kim SW

Nephrotic syndrome and liver cirrhosis are common clinical manifestations, and are associated with avid sodium retention leading to the development of edema and ascites. However, the mechanism for the sodium...
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Pathophysiology and clinical characteristics of hypothalamic obesity in children and adolescents

Kim JH, Choi JH

The hypothalamus plays a key role in the regulation of body weight by balancing the intake of food, energy expenditure, and body fat stores, as evidenced by the fact that...
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