- CaMKII Inhibitor KN-62 Blunts Tumor Response to Hypoxia by Inhibiting HIF-1alpha in Hepatoma Cells
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Lee KH
- KMID: 2071702
- Korean J Physiol Pharmacol.
- 2010 Oct;14(5):331-336.
- doi: 10.4196/kjpp.2010.14.5.331
In rapidly growing tumors, hypoxia commonly develops due to the imbalance between O2 consumption and supply. Hypoxia Inducible Factor (HIF)-1alpha is a transcription factor responsible for tumor growth and angiogenesis... -
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- Effects of Vanadate and Pervanadate on Contraction of Cat Gastric Smooth Muscle
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Sim SS, Choi HB, Shim HS, Rhie DJ, Hahn SJ, Yoon SH, Kim MS, Jo YH
- KMID: 2084877
- Korean J Gastroenterol.
- 1999 Jan;33(1):1-10.
BACKGROUND/AIMS: Activated mammalian cells produce the reactive oxygen species from oxygen and they convert vanadate into pervanadate. The aim of the present study was to compare the contactile mechanisms of... -
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- Opening of ATP-sensitive K+ channel by pinacidil requires serine/threonine phosphorylation in rat ventricular myocytes
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Kwak YG, Chae SW
- KMID: 2285223
- Korean J Physiol Pharmacol.
- 1999 Jun;3(3):293-303.
The influences of specific protein phosphatase and protein kinase inhibitors on the ATP-sensitive K+ (KATP) channel-opening effect of pinacidil were investigated in single rat ventricular myocytes using patch clamp technique. In cell-attached patches,... -
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- Antagonists of NMDA Receptor, Calcium Channel and Protein Kinase C Potentiate Inhibitory Action of Morphine on Responses of Rat Dorsal Horn Neuron
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Shin HK, Kim YS, Jun JH, Lee SE, Kim JH
- KMID: 1517040
- Korean J Physiol Pharmacol.
- 2003 Oct;7(5):251-254.
he present study was designed to examine whether the co-application of morphine with Ca2+ channel antagonist (Mn2+, verapamil), N-methyl-D-aspartate (NMDA) receptor antagonist (2-amino-5-phosphonopentanoic acid[AP5], Mg2+) or protein kinase C inhibitor... -
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- Impaired Endothelium-Dependent Relaxation by Alternating Protein Kinase C and Na+-K+ ATPase in Isolated Rabbit Corpus Cavernosum Exposed to Elevated Glucose
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Jung SY, Hwang TK, Yoon JY
- KMID: 1991324
- Korean J Urol.
- 1997 May;38(5):463-472.
Impaired endothelium dependent relaxation occurs in diabetic rabbit corpus cavernosum and normal corpus cavernosum exposed to elevated glucose. Elevation of glucose can change the activities of two key enzymes, protein... -
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- Regulation of the contraction induced by emptying of intracellular Ca2+ stores in cat gastric smooth muscle
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Baek HJ, Sim SS, Rhie DJ, Yoon SH, Hahn SJ, Jo YH, Kim MS
- KMID: 1982597
- Korean J Physiol Pharmacol.
- 2000 Apr;4(2):113-120.
To investigate the mechanism of smooth muscle contraction induced by emptying of intracellular Ca2+ stores, we measured isometric contraction and 45Ca2+ influx. CaCl2 increased Ca2+ store emptying- induced contraction in dose-dependent manner, but... -
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- Role of NF- kappaB binding sites in the regulation of inducible nitric oxide synthase by tyrosine kinase
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Ryu YS, Hong JH, Lim JH, Bae SH, Ahn IS, Seok JH, Lee JH, Hur GM
- KMID: 1606839
- Korean J Physiol Pharmacol.
- 2001 Feb;5(1):55-63.
In macrophages, lipopolysaccharide (LPS) alone or in combination with interferon- gamma (IFN- gamma) has been shown to release a nitric oxide (NO) through the increase of the transcription of the inducible nitric oxide... -
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- Contractile Responses to Endothelins in Isolated Arteries from Human Uterus
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Choi OH, Jang MK, Rhim BY
- KMID: 2261368
- Korean J Obstet Gynecol.
- 1999 Mar;42(3):582-590.
OBJECTIVE: We examined the vasoconstricting poperties of endothelin (ET) on isolated arteries from pregnant as well as non-pregnant uterus. METHODS: Arteries of the uterus were obtained from both hysterectomized uterus... -
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- Ca2+ Sensitization Mechanism in Stretch-induced Myogenic Tone
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Kim JS, Ryu SK, Ahn DS, Kang BS, Lee YH
- KMID: 1614857
- Korean J Physiol Pharmacol.
- 2002 Feb;6(1):33-40.
It has been suggested that Ca2+ sensitization mechanisms might contribute to myogenic tone, however, specific mechanisms have not yet been fully identified. Therefore, we investigated the role of protein kinase... -
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- Changes in Myogenic Tone in Spontaneously Hypertensive Rat: Role of RhoA and Protein Kinase C
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Seo JP, Ryu SK, Kang NY, Ahn DS, Lee YH
- KMID: 1938907
- Korean Circ J.
- 2002 Mar;32(3):257-267.
- doi: 10.4070/kcj.2002.32.3.257
BACKGROUND AND OBJECTIVES: The myogenic response was originally described as a contraction of a blood vessel that occurred following an increase in intravascular distending pressure. Conversely, a reduction in intravascular... -
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- Effects of protein kinase C modulation on hepatic hemodynamics and glucoregulation
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Lee JW, Kong ID, Park KS, Chung HS, Filkins JP
- KMID: 2071560
- Korean J Physiol Pharmacol.
- 1999 Dec;3(6):571-578.
This study evaluated the effects of PKC activation using phorbol 12-myristate 13-acetate (PMA) and PKC inhibition using the isoquinoline sulfomide derivative H-7 on hemodynamics and glucoregulation in the isolated perfused rat liver. Livers... -
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- The enhancement of endotoxin-induced nitric oxide production by elevation of glucose concentration in macrophage
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Woo HG, Jung YS, Baik EJ, Moon CH, Lee SH
- KMID: 1554063
- Korean J Physiol Pharmacol.
- 1999 Aug;3(4):447-454.
The production of nitric oxide (NO) and the expression of inducible nitric oxide synthase (iNOS) are known to be modulated by a variety of factors. Recent study showed that endotoxin-induced NO synthesis... -
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