- The DPE, a core promoter element for transcription by RNA polymerase II
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Kadonaga J
- KMID: 931875
- Exp Mol Med.
- 2002 Sep;34(4):259-264.
The core promoter is an important yet often overlooked component in the regulation of transcription by RNA polymerase II. In fact, the core promoter is the ultimate target of... -
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- Transcription repression of a CCAAT-binding transcription factor CBF/HSP70 by p53
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Chae HD, Yun J, Shi D
- KMID: 1089459
- Exp Mol Med.
- 2005 Oct;37(5):488-491.
NF-Y transcription factor binds to CCAAT boxes on promoters of cell cycle regulatory genes such as cdc2, cyclin B, cdc25C, and cyclin A. We previously reported that the DNA binding... -
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- Pitt-Hopkins Syndrome: intellectual disability due to loss of TCF4-regulated gene transcription
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Sweatt JD
- KMID: 2154240
- Exp Mol Med.
- 2013 May;45(5):e21.
TCF4 (transcription factor 4; E2-2, ITF2) is a transcription factor that when haplo-insufficient causes Pitt-Hopkins Syndrome (PTHS), an autism-spectrum disorder that is associated with pervasive developmental delay and severe intellectual... -
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- CpG methylation at GATA elements in the regulatory region of CCR3 positively correlates with CCR3 transcription
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Uhm TG, Lee SK, Kim BS, Kang JH, Park CS, Rhim TY, Chang HS, Kim DJ, Chung IY
- KMID: 1365904
- Exp Mol Med.
- 2012 Apr;44(4):268-280.
- doi: 10.3858/emm.2012.44.4.022
DNA methylation may regulate gene expression by restricting the access of transcription factors. We have previously demonstrated that GATA-1 regulates the transcription of the CCR3 gene by dynamically interacting with... -
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- ATM modulates transcription in response to histone deacetylase inhibition as part of its DNA damage response
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Jang ER, Choi JD, Park MA, Jeong G, Cho H, Lee JS
- KMID: 946652
- Exp Mol Med.
- 2010 Mar;42(3):195-204.
- doi: 10.3858/emm.2010.42.3.020
Chromatin structure has a crucial role in a diversity of physiological processes, including development, differentiation and stress responses, via regulation of transcription, DNA replication and DNA damage repair. Histone deacetylase... -
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- STP-A11, an oncoprotein of Herpesvirus saimiri augments both NF-kappaB and AP-1 transcription activity through TRAF6
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Jeong S, Cho IR, An WG, Jhun BH, Lee BS, Park K, Chung YH
- KMID: 1103681
- Exp Mol Med.
- 2007 Feb;39(1):56-64.
Herpesvirus saimiri (HVS), a member of the gamma-herpesvirus family, encodes an oncoprotein called Saimiri Transforming Protein (STP) which is required for lymphoma induction in non-human primates. However, a detailed mechanism... -
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- Sequence Analyses of Aberrant FHIT Transcripts in Gastric Cancer Cell Lines
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Lee SH, Kim HS
- KMID: 1066038
- Korean J Gastroenterol.
- 2003 Dec;42(6):476-483.
BACKGROUND/AIMS: The fragile histidine triad (FHIT) gene located at chromosome 3p14.2, is a candidate tumor suppressor gene often involved in various tumors. Homozygous deletions, lack or reduced expression of... -
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- Identification of a putative transactivation domain in human Nanog
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Oh JH, Do HJ, Yang HM, Moon SY, Cha KY, Chung HM, Kim JH
- KMID: 1056238
- Exp Mol Med.
- 2005 Jun;37(3):250-254.
Nanog is a newly identified divergent homeodomain protein that directs the infinite propagation and sustains the pluripotency of embryonic stem cells. It has been reported that murine Nanog has two... -
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- Transcriptional regulation of Zic3 by heterodimeric AP-1(c-Jun/c-Fos) during Xenopus development
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Lee SY, Lee HS, Moon JS, Kim JI, Park JB, Lee JY, Park MJ, Kim J
- KMID: 1123768
- Exp Mol Med.
- 2004 Oct;36(5):468-475.
The heterodimeric c-Jun/c-Fos, an activator protein-1 (AP-1) has been implicated in mesoderm induction (Dong et al., 1996; Kim et al., 1998) whereas the homodimer of c-Jun was reported to be... -
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- Coordinated transcriptional regulation of calmegin, a testis-specific molecular chaperon, by histone deacetylase and CpG methyltransferase
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Kim DH, Shim JS, Kwon HJ
- KMID: 1089460
- Exp Mol Med.
- 2005 Oct;37(5):492-496.
Calmegin is a testis-specific molecular chaperon playing a key role in spermatogenesis. However, the transcriptional regulatory mechanisms for calmegin expression are entirely unknown. Herein, we revealed that calmegin is transcriptionally... -
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- Regulation of fatty acid synthase at transcriptional and post-transcriptional levels in rat liver
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Kim KS, Park SW, Kim YS
- KMID: 1120230
- Yonsei Med J.
- 1992 Sep;33(3):199-208.
- doi: 10.3349/ymj.1992.33.3.199
The regulation of fatty acid synthase in rat liver was investigated at transcriptional and post-transcriptional levels. When rats were fasted for 3 days and refed on a high-carbohydrate diet, the... -
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- Transcriptional Activity of Plasmodium Subtilisin-like Protease 2 (Pf-Sub2) 5'Untranslated Regions and Its Interaction with Hepatocyte Growth Factor
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Liao S, Liu Y, Jung SY, Cho PY, Zheng B, Park H
- KMID: 1104694
- Korean J Parasitol.
- 2010 Dec;48(4):291-295.
- doi: 10.3347/kjp.2010.48.4.291
The onset, severity, and ultimate outcome of malaria infection are influenced by parasite-expressed virulence factors and individual host responses to these determinants. In both humans and mice, liver injury is... -
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- Expression and Regulation of Latent TGF-beta Binding Protein-1 Transcripts and Their Splice Variants in Human Glomerular Endothelial Cells
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Kwak JH, Woo JS, Shin K, Kim HJ, Jeong HS, Han DC, Kim SI, Park CS
- KMID: 1712745
- J Korean Med Sci.
- 2005 Aug;20(4):628-635.
- doi: 10.3346/jkms.2005.20.4.628
Latent transforming growth factor (TGF)-beta-binding protein (LTBP) is required for the assembly, secretion, matrix association, and activation of latent TGF-beta complex. To elucidate the cell specific expression of the genes... -
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