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The Role of High Mobility Group Box 1 in Innate Immunity

Lee SA, Kwak MS, Kim S, Shin JS

With growing accounts of inflammatory diseases such as sepsis, greater understanding the immune system and the mechanisms of cellular immunity have become primary objectives in immunology studies. High mobility group...
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Role of Innate Immunity in the Pathogenesis of Type 1 and Type 2 Diabetes

Lee MS

The importance of innate immunity in host defense is becoming clear after discovery of innate immune receptors such as Toll-like receptor or Nod-like receptor. Innate immune system plays an important...
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Endothelial Dysfunction: Clinical Implications in Cardiovascular Disease and Therapeutic Approaches

Park KH, Park WJ

Atherosclerosis is a chronic progressive vascular disease. It starts early in life, has a long asymptomatic phase, and a progression accelerated by various cardiovascular risk factors. The endothelium is an...
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Intrinsic and Extrinsic Regulation of Innate Immune Receptors

Jeong E, Lee JY

Pattern recognition receptors (PRRs) in innate immune cells play a pivotal role in the first line of host defense system. PRRs recognize pathogen-associated molecular patterns (PAMPs) or danger-associated molecular patterns...
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