J Korean Pediatr Soc.  2000 Nov;43(11):1480-1487.

Serum Lipid Levels and Fatty Acid Metabolism in the Rat With Adriamycin Induced Cardiomyopathy

• Hong YM
• Yoon HR

Abstract

PURPOSE: Adriarnycin induced cardiomyopathy is irreversible and may procede to clinical congestive heart failure. Recently, it has been suggested that adriamycin may exert cardiomyopathy due to inhibition of transport across mitochondrial membranes rnediated by the carnitine palmitoyltransferase system(CPT I). The effect of adriamycin on fatty acid metabolisrn according to cumulative dose was not clarified. The purpose of this study was to ascertain the acute effect of adriamycin on lipid and fatty acid metabolism accoring to cumulative dose.
METHODS
Sprague-Dawley rats were divided into two groups. The first group was control. The second group was given intraperitoneal injection with adriamycin(5mg/kg) twice a week for 2 weeks. Serum lipid (total cholesterol, triglyceride, HDL cholesterol, LDL cholesterol) and fatty acid levels were analyzed on the first day, 8th day, and 11th day after injection of adriamycin.
RESULTS
Total cholesterol, triglyceride, and LDL cholesterol were significantly higher in adriamycin group compared to the control group. HDL cholesterol was similar in both groups. Total cholesterol and LDL choleterol level significantly increased over the adriamycin dose. Total fatty acid levels were significantly higher after injection of adriamycin. Long chain fatty acids such as palmitic acid, linoleic acicl and oleic acid levels were significantly elevated in the adriamycin group.
CONCLUSION
Serum lipid and fatty acid levels increased significantly after injection of adriamycin.

Keyword

Adriamycin; Cardiomyopathy; Lipid; Fatty acid

MeSH Terms

Animals
Cardiomyopathies*
Carnitine O-Palmitoyltransferase
Cholesterol
Cholesterol, HDL
Cholesterol, LDL
Doxorubicin*
Fatty Acids
Heart Failure
Injections, Intraperitoneal
Metabolism*
Mitochondrial Membranes
Oleic Acid
Palmitic Acid
Rats*
Rats, Sprague-Dawley
Triglycerides
Carnitine O-Palmitoyltransferase
Cholesterol
Cholesterol, HDL
Cholesterol, LDL
Doxorubicin
Fatty Acids
Oleic Acid
Palmitic Acid