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Ann Surg Treat Res. 2016 Dec;91(6):278-287. English. Original Article.
Lee CR , Lee S , Son H , Ban E , Kang SW , Lee J , Jeong JJ , Nam KH , Chung WY , Park CS .
Department of Surgery, Yonsei University College of Medicine, Seoul, Korea.
Department of Surgery, The Catholic University of Korea, College of Medicine, Seoul, Korea.
Department of Surgery, Catholic Kwandong University International St. Mary's Hospital, Incheon, Korea.

PURPOSE: The objective of this study was to review the clinical outcome and prognosis of patients with sporadic and hereditary medullary thyroid cancer (MTC) who were treated at a single tertiary hospital in Korea. METHODS: We retrospectively reviewed the case files of 85 patients treated from August 1982 to February 2012. RESULTS: In all, 65 patients (76.5%) had sporadic MTC and 20 patients (23.5%) had hereditary MTC. Patients in the sporadic group were older than in the hereditary group (P < 0.001). However, the hereditary group had more tumor multiplicity (P < 0.001) and bilaterality (P < 0.001). Neither survival rate was significantly different between the sporadic and hereditary groups (P = 0.775 and P = 0.866). By multivariate analysis, distant metastasis was a significant prognostic factor for overall and progression-free survival. CONCLUSION: In general, patients with MTC have favorable outcomes. Distant metastasis appears to be the strongest predictor of overall and progression-free survival.

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