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Ann Surg Treat Res. 2016 Dec;91(6):278-287. English. Original Article. https://doi.org/10.4174/astr.2016.91.6.278
Lee CR , Lee S , Son H , Ban E , Kang SW , Lee J , Jeong JJ , Nam KH , Chung WY , Park CS .
Department of Surgery, Yonsei University College of Medicine, Seoul, Korea. jungjongj@yuhs.ac
Department of Surgery, The Catholic University of Korea, College of Medicine, Seoul, Korea.
Department of Surgery, Catholic Kwandong University International St. Mary's Hospital, Incheon, Korea.
Abstract

PURPOSE: The objective of this study was to review the clinical outcome and prognosis of patients with sporadic and hereditary medullary thyroid cancer (MTC) who were treated at a single tertiary hospital in Korea. METHODS: We retrospectively reviewed the case files of 85 patients treated from August 1982 to February 2012. RESULTS: In all, 65 patients (76.5%) had sporadic MTC and 20 patients (23.5%) had hereditary MTC. Patients in the sporadic group were older than in the hereditary group (P < 0.001). However, the hereditary group had more tumor multiplicity (P < 0.001) and bilaterality (P < 0.001). Neither survival rate was significantly different between the sporadic and hereditary groups (P = 0.775 and P = 0.866). By multivariate analysis, distant metastasis was a significant prognostic factor for overall and progression-free survival. CONCLUSION: In general, patients with MTC have favorable outcomes. Distant metastasis appears to be the strongest predictor of overall and progression-free survival.

Copyright © 2019. Korean Association of Medical Journal Editors.