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Korean J Gynecol Oncol Colposc. 2001 Dec;12(4):318-324. Korean. Original Article.
Kim YJ , Moon HS , Chung HW , Kim SC , Kim HR .
Department of Obstetrics & Gynecology, College of Medicine, Ewha Womans Univercity, and Medical Research Center.
Department of Biochemistry, College of Medicine, Ewha Womans Univercity, and Medical Research Center.
Abstract

OBJECTIVE: The aims of this study were to determine whether polymorphisms of the interleukin-6 promoter might be associated with an increased risk of cervical cancer. METHODS: The bloods were obtained from healthy women(n=130), and patients with cervical cancer(n=109). The IL- 6 promoter was examined with allele-specific PCR method. The clinical characteristics of patients were compared between two groups. RESULTS: There is IL-6-572 SNP. The genotypic distribution in cervical cancer patients were GG genotype 55(50.5%), GC genotype 45(41.3%), CC genotype 9(8.2%). There were no stastistical differences of each genotypes between control group and cervical cancer group. (p>0.05) CONCLUSION: Our results suggested that SNP of IL-6 promoter is not related with the carcinogenesis of cervical cancer.

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