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Clin Exp Reprod Med. 2014 Sep;41(3):137-139. English. Brief Communication.
Yoon HJ , Kim HJ , Bae IH , Chae SJ , Yoon SH , Lee WD , Lim JH .
Maria Reproductive Center, Department of Obstetrics and Gynecology, Maria Fertility Hospital, Seoul, Korea.
Maria Research Center, Seoul, Korea.

The effect of artificial oocyte activation (AOA) with a calcium ionophore on intracytoplasmic morphologically selected sperm injection (IMSI) was examined in patients with histories of repeated failed implantation attempts. Four singleton pregnancies and one twin pregnancy were obtained after embryos transfer (5/14, 35.7%). Therefore, AOA combined with IMSI can be considered an option for cycles with a fertilization defect and recurrent implantation failures.

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