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Ann Lab Med. 2012 Sep;32(5):366-369. English. Case Reports.
Jeon YL , Nam YS , Lim G , Cho SY , Kim YT , Jang JH , Kim J , Park M , Lee HJ .
Department of Medicine, Graduate School, Kyung Hee University, Seoul, Korea.
Department of Biomedical Science, Kyung Hee University Graduate School, Seoul, Korea.
Department of Laboratory Medicine, School of Medicine, Kyung Hee University, Seoul, Korea.
Department of Molecular Biology, Seoul Medical Science Institute/Seoul Clinical Laboratories, Seoul, Korea.
Division of Enteric Bacterial Infections, Center for Infectious Disease, National Institute of Health, Seoul, Korea.

We report a recent case in which ciprofloxacin-resistant Shigella flexneri was isolated from a 23-yr-old female patient with a history of travel to India. Prior to her admission to our internal medicine department, she experienced symptoms of high fever and generalized weakness from continuous watery diarrhea that developed midway during the trip. S. flexneri was isolated from the stool culture. Despite initial treatment with ciprofloxacin, the stool cultures continued to show S. flexneri growth. In the susceptibility test for antibiotics of the quinolone family, the isolate showed resistance to ciprofloxacin (minimum inhibitory concentration [MIC], 8 microg/mL), norfloxacin (MIC, 32 microg/mL), ofloxacin (MIC, 8 microg/mL), nalidixic acid (MIC, 256 microg/mL), and intermediate resistance to levofloxacin (MIC, 4 microg/mL). In molecular studies for quinolone resistance related genes, plasmid borne-quinolone resistance genes such as qnrA, qnrB, qnrS, aac(6')-Ib-cr, qepA, and oqxAB were not detected. Two mutations were observed in gyrA (248C-->T, 259G-->A) and 1 mutation in parC (239G-->T). The molecular characteristics of the isolated S. flexneri showed that the isolate was more similar to the strains isolated from the dysentery outbreak in India than those isolated from Korea.

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