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Ann Lab Med. 2012 Sep;32(5):362-365. English. Case Reports. https://doi.org/10.3343/alm.2012.32.5.362
Yang JJ , Cho SY , Suh JT , Lee HJ , Lee WI , Yoon HJ , Baek SK , Park TS .
Department of Medicine, Graduate School, Kyung Hee University, Seoul, Korea.
Department of Laboratory Medicine, School of Medicine, Kyung Hee University, Seoul, Korea. 153jesus@hanmail.net
Department of Hematology-Oncology, School of Medicine, Kyung Hee University, Seoul, Korea.
Abstract

An 87-yr-old woman was diagnosed with AML with myelodysplasia-related changes (AML-MRC). The initial complete blood count showed Hb level of 5.9 g/dL, platelet counts of 27x10(9)/L, and white blood cell counts of 85.33x10(9)/L with 55% blasts. Peripheral blood samples were used in all the tests, as bone marrow examination could not be performed because of the patient's extremely advanced age and poor general health condition. Flow cytometric analysis, chromosome analysis, FISH, and reverse transcriptase-PCR (RT-PCR) results indicated AML-MRC resulting from t(3;21) with the RUNX1-MECOM fusion gene. To our knowledge, this is the second most elderly de novo AML patient associated with t(3;21) to be reported.

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