Hearing aids are one of the rehabilitative options for individuals with late onset auditory neuropathy spectrum disorder (ANSD). There is a growing body of evidence that supports the effectiveness of hearing aids among these individuals. The objective of the study was to review the behavioural and electrophysiological factors that determine the effectiveness of amplification in individuals with late onset ANSD. An intensive search was carried out using the PubMed, SpringerLink and Google Scholar databases using the following keywords: auditory neuropathy, late onset ANSD, hearing aids and amplification. There were both retrospective and experimental research studies that showed aided improvement in individuals with late onset ANSD. The aided improvement in these studies has been attributed to preserved neural synchrony. Hence, it was concluded that, hearing aids are effective in improving speech perception in a sub-group of individuals with late onset ANSD. Measures that evaluate neural synchrony are promising tools to identify the sub-group of such individuals. Speech identification scores at higher sensation levels and cortical potentials are the two clinical measures that indicate aided performance in individuals with late onset ANSD.