Moraxella lacunata is part of the normal flora of the mucosal surface and skin. It is considered to have low pathogenic potential and has been known to cause eye infection but rarely systemic infection. We experienced a case of septicemia due to M. lacunata in a 28-year-old man who was admitted to our hospital due to high fever. He had been well untill 3 weeks earlier when he experienced fever. Physical examination revealed no audible heart murmur and echocardiogram revealed no remarkable abnormalities. Culture of blood revealed M. lacunata. The patient expired due to subdural hemorrhage, 12th days after admission. We report the case with a brief review of related literature.