Cryptococcosis is a systemic infection caused by the yeast-like fungus Cryptococcus neoformans, involving central nervous system, lung, skin, prostate and bone. We have experienced a case of pulmonary cryptococcosis without involving other organ in healthy person. A previously healthy 74-year old female patient was admitted due to cough, sputum, general weakness and perioral numbness. As compared with chest PA that was taken 1 year before admission, single nodule of left upper lobe was enlarged slightly. CT-guided needle aspiration and biopsy were done and cryptococcosis was diagnosed by pathology. After central nervous system infection was excluded, oral fluconazole was given for 12 weeks. The cryptococcoma was nearly disappeared with 12-weeks' treatment and did not relapse until 6 month later.