Journal Browser Advanced Search Help
Journal Browser Advanced search HELP
Korean J Asthma Allergy Clin Immunol. 2011 Sep;31(3):177-183. Korean. Original Article.
Jung YH , Ko H , Kim HY , Seo JH , Kwon JW , Kim BJ , Kim HB , Lee SY , Jang GC , Song DJ , Kim WK , Shim JY , Hong SJ .
Department of Pediatrics, Asan Medical Center, University of Ulsan College of Medicine, Childhood Asthma Atopy Center, Seoul, Korea. sjhong@amc.seoul.kr
Research Center for Standardization of Allergic Diseases, Seoul, Korea.
Department of Pediatrics, Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea.
Department of Pediatrics, Haeundae Paik Hospital, Busan, Korea.
Department of Pediatrics, Inje University Sanggye Paik Hospital, Seoul, Inje University College of Medicine, Seoul, Korea.
Department of Pediatrics, Hallym Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Korea.
Department of Pediatrics, National Health Insurance Corporation Ilsan Hospital, Ilsan, Korea.
Department of Pediatrics, Guro Hospital, Korea University College of Medicine, Seoul, Korea.
Department of Pediatrics, Inje University Seoul Paik Hospital, Inje University College of Medicine, Seoul, Korea.
Department of Pediatrics, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.
Abstract

BACKGROUND: The aim of this study was to investigate the prevalence of food allergy (FA) and determine its risk factors in the preschool urban children in Seoul, Korea. METHODS: A modified International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire was used to survey 933 pre-school children from nine urban areas of Seoul in Korea. The risk factor analysis was done by logistic regression analysis. RESULTS: In preschool children, the lifetime and recent 12-month prevalence of FA symptoms were 21.0% and 10.6%, respectively. The lifetime prevalence of FA diagnosis was 6.1%, the prevalence of current FA (12-month symptoms and diagnosis) was 3.3%, and the recent 12-month prevalence of FA treatment was 3.6%. Blood eosinophils [0] in FA group and Non-FA group were 5.00+/-3.93% and 3.93+/-2.91%, respectively (P=0.002). The median total Immunoglobulin E (IgE) of FA group was 102 (interquatile [IQ] range 44.8-257) IU/mL, the median total IgE of Non-FA group was 70.9 (IQ range 70.9-161) IU/mL (P=0.001). Parental FA (adjusted odds ratio [aOR], 2.17; 95% confidence interval [CI], 1.22-3.85), past history of AD diagnosis (aOR, 3.69; 95% CI, 2.33-5.85), eczema on doctor's physical examination (aOR, 3.74; 95% CI, 2.16-6.47), use of antibiotics during infancy more than 3 days (aOR, 1.72; 95% CI, 1.08-2.73) were the independent risk factors for FA symptoms within 12 months. CONCLUSION: In preschool urban children in Seoul, the lifetime prevalence of FA diagnosis was 6.1%, the recent 12 month prevalence of FA treatment was 3.6%. The prevalences of AD and doctor examined AD in FA group were significantly higher compared to Non-FA group. Family history, and the use of antibiotics during infancy could be the independent risk factors for the development of FA.

Copyright © 2019. Korean Association of Medical Journal Editors.