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Korean J Asthma Allergy Clin Immunol. 2010 Dec;30(4):307-313. Korean. Original Article.
Kim YJ , Kim HJ , Kang MJ , Kwon JW , Seo JH , Kim BJ , Yu J , Hong SJ .
Asan Institute for Life Sciences, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Department of Pediatrics, Childhood Asthma Atopy Center, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. sjhong@amc.seoul.kr
Department of Pediatrics, Inje University, Haeundae Paik Hospital, Busan, Korea.
Abstract

BACKGROUND: Asthma is a chronic allergic disease characterized by the infiltration of eosinophils into the airway and lung. Bacille Calmette-Guerin (BCG) has been reported to be beneficial to inhibit allergic inflammation in an animal asthma model. OBJECTIVE: The aims of the study were to investigate the efficacy of BCG according to the time point of administration on asthma in a murine model. METHOD: BALB/c mice were treated with BCG (1x106 CFUs) before sensitization (-5 days) or after sensitization (+12 days) in asthma-induced BALB/c mice by ovalbumin (OVA) sensitization. Bronchial hyperresponsiveness (BHR), influx of inflammatory cells in bronchoalveolar lavage (BAL) fluid, histopathological changes in the lung and systemic immune responses were assessed. RESULT: The administration of BCG before and after sensitization suppressed asthmatic responses, including BHR, OVA-specific immunoglobulin E (IgE) production, percentage of eosinophils in BALF and pulmonary eosinophilic inflammation in the murine model compared to the control group. However, total IgE, total cell count and OVA-IgG1 were significantly suppressed by BCG before sensitization only. CONCLUSION: BCG vaccinations, regardless of administration time point, suppressed asthmatic responses in mice. The mechanism of effect of BCG before sensitization is thought to be balance Th1/Th2 immune responses, but, that of BCG after sensitization may be different from BCG before sensitization.

Copyright © 2019. Korean Association of Medical Journal Editors.